Gene interactions and pathways from curated databases and text-mining

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IL10 — PARP1

Text-mined interactions from Literome

Aldinucci et al., J Immunol 2007 : In the same cultures, PARP-1 inhibitors also reduced production of IL-12 and IL-10 ... In the same cultures, PARP-1 inhibitors also reduced production of IL-12 and IL-10
Kang et al., J Immunol 2010 (Genetic Predisposition to Disease...) : These findings unveil a novel role of PARP-1 in the regulation of IL-10 production in an allele dependent way, which determines individual susceptibility to sepsis induced inflammatory pathology and the immunological sequelae in a physiological process in which clearance of infection induced apoptotic cells by professional phagocytes triggers the cytokine synthesis