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BCL2 — FGF2

Text-mined interactions from Literome

Bryckaert et al., Oncogene 1999 : FGF2 also increased the de novo synthesis and the production of Bcl-xl before the onset of apoptosis
Pardo et al., J Biol Chem 2002 : Fibroblast growth factor-2 induces translational regulation of Bcl-XL and Bcl-2 via a MEK dependent pathway : correlation with resistance to etoposide induced apoptosis
Teh et al., J Cell Biochem 2004 (Breast Neoplasms...) : bFGF reduced apoptosis in MCF-7 breast cancer cells and up-regulated the expression of mitocondrial Bcl-2 , whereas COX inhibitors meloxicam ( selective COX-2 ) and aspirin ( non-selective ), induced apoptosis
von Willebrand et al., Exp Dermatol 2005 (Melanoma...) : FGF-2 blocks TGF-beta1 mediated suppression of Bcl-2 in normal melanocytes ... In conclusion, our results suggest that a reduction in the level of the anti-apoptotic Bcl-2 is involved in the execution of apoptosis induced by TGF-beta1 in normal melanocytes cultured on collagen gel and that FGF-2 can prevent TGF-beta1 from causing this reduction
Huang et al., J Pharmacol Sci 2006 : However, in the presence of FGF-2 , Bcl-2 phosphorylation was blocked, and the Ras/Raf/ERK signal pathway was activated and protected against the oridonin induced apoptosis by the alternative function of promoting of Bcl-2 expression
O'Driscoll et al., J Neurochem 2007 : Activation of the transcription factor cAMP-response element binding protein ( CREB ) and subsequent up-regulation of Bcl-2 in response to bFGF was also dependent on PKA as inhibition with H-89 attenuated increased pCREB levels and Bcl-2 expression
Wang et al., Mol Biol Rep 2011 : The effect of Ad-sh-bFGF on Bcl-2 gene expression was also examined
Yoon et al., Biochem J 2012 : Phospholipase D1 mediates bFGF induced Bcl-2 expression leading to neurite outgrowth in H19-7 cells ... We found that Bcl-2 expression was maximally induced by bFGF within 24 h, and that this effect was reduced by inhibiting PLD1 expression with PLD1 small interfering RNA or by overexpressing DN ( dominant negative ) -PLD1, whereas PLD1 overexpression markedly induced Bcl-2 expression
Sgadari et al., International journal of vascular medicine 2011 : Upregulation of Bcl-2 expression by combined FGF-2 and Tat occurs also in vitro, and this protects human primary endothelial cells from programmed cell death
Kim et al., BMB Rep 2012 : Chemical inhibition of FGFR, NFkB, and PI3K activity by PD173074, pyrrolidine dithiocarbamate, and LY294002 respectively abrogated the FGF-2 mediated induction of Bcl2-A1 and Bcl-xL expression
Wieder et al., Growth Factors 1997 (Cell Transformation, Neoplastic) : Exogenous bFGF induces higher Bcl-2 levels in a dose dependent manner and recapitulates the antiapoptotic effects of the overexpressed species but fails to induce changes associated with the transformed phenotype ... Although low level expression of bFGF or exogenous bFGF is sufficient to upregulate Bcl-2 and delay apoptosis, high intracellular levels are required for cellular transformation
Karsan et al., Am J Pathol 1997 : Of these family members, only Bcl-2 is induced by FGF-2