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CRH — GHRH

Pathways - manually collected, often from reviews:

• Reactome Reaction: CRH → GHRH (reaction) Wenzel-Seifert et al., Biochem Pharmacol 2002, Zhang et al., Eur J Pharmacol 2003, Mitsuhashi et al., J Biol Chem 1989, Kozasa et al., Proc Natl Acad Sci U S A 1988, Baker et al., J Biol Chem 1998

Text-mined interactions from Literome

Honegger et al., Endocrinology 1991 : Stimulation of GHRH and SRIH could not be blocked by the CRH-antagonist alpha-helical CRH ( 9-41 ) at 10 ( -6 ) M. Interleukin-6, in the dose range 10-100 U/ml, and tumor necrosis factor-alpha, in the dose range 10-10,000 U/ml, had no effect on the acute hypothalamic release of either GHRH or SRIH
Luque et al., Endocrinology 2007 : These observations, in light of previous reports showing both NPY and CRH can inhibit GHRH expression and GH release, suggest that these neuronal systems may work in concert to control the ultimate impact of fasting on GH axis function
Nakane et al., Life Sci 1987 (Pituitary Neoplasms) : Corticotropin releasing factor (CRF) and both human pancreatic growth hormone releasing factor ( hp-GRF ) and rat hypothalamic GRF ( rh-GRF ) stimulated ACTH release from neoplastic AtT-20 mouse pituitary tumor cells in a dose dependent fashion, with CRF inducing a 10-fold increase and GRF a maximal increment of approximately one-half that of CRF