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NQO1 — PTGS2

Text-mined interactions from Literome

Hoshino et al., J Med Chem 2010 : Two metabolites showed activity in these assays ; the 3-sulfate exhibited QR1 induction, DPPH free radical scavenging, and COX-1 and COX-2 inhibitory activities and the 4'-sulfate inhibited NFkappaB induction, as well as COX-1 and COX-2 activities
Yang et al., In Vivo 2013 : Molecularly, 4-NQO inhibited Rarß2 but induced expression of phosphorylated extracellular-signal regulated kinase-1 and -2 ( p-ERK1/2 ) and Cox2 proteins and Rarß2 gene promoter methylation in murine tumors