◀ Back to BCL2

BCL2 — NFKBIA

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: NFKBIA → BCL2 (increases) de Moissac et al., J Biol Chem 1998*
  Evidence: The Bcl-2-mediated loss of IkappaBalpha could be prevented by the proteasome inhibitor lactacystin, consistent with the notion that the targeted degradation of IkappaBalpha consequent to overexpression of Bcl-2 utilizes the ubiquitin-proteasome pathway. This was further tested in human 293 cells in which the N-terminal region of IkappaBalpha was identified to be an important regulatory site for Bcl-2. Deletion of this region or a serine to alanine substitution mutant at amino acids 32 and 36, w...

Text-mined interactions from Literome

Kirshenbaum et al., Clin Invest Med 2000 : The mode by which Bcl-2 regulates IkappaBalpha was related to the N-terminal phosphorylation and degradation of IkappaBalpha by the proteasome since an N-terminal deletion mutant of IkappaBalpha or the proteasome inhibitor lactacystin abrogated Bcl-2 's inhibitory effects on IkappaBalpha and prevented NFkappaB activation
Ramirez et al., J Neurochem 2001 (AIDS Dementia Complex) : Overexpression of the super-repressor IkappaB-alpha mutant prevented this induction of Bcl-2 expression
Regula et al., J Biol Chem 2002 (MAP Kinase Signaling System) : Here we demonstrate that expression of Bcl-2 in ventricular myocytes resulted in an increase in NF-kappa B-dependent DNA binding, NF-kappa B gene transcription and reduced I kappa B alpha levels ... Catalytically inactive mutants of IKK beta, but not IKK alpha, suppressed Bcl-2 mediated I kappa B alpha phosphorylation and NF-kappa B activation
de Moissac et al., J Biol Chem 1998 : To our knowledge, this provides the first evidence for the regulation of IkappaBalpha by Bcl-2 and suggests a link between Bcl-2 and the NFkappaB signaling pathway in the suppression of apoptosis