◀ Back to EXOSC2
EXOSC2 — XRN1
Pathways - manually collected, often from reviews:
-
Reactome Reaction:
EXOSC2
→
XRN1
(indirect_complex)
Chen et al., Cell 2001, Lai et al., Mol Cell Biol 2003, Raineri et al., Nucleic Acids Res 2004, Lykke-Andersen et al., Genes Dev 2005, Hau et al., J Cell Biochem 2007, Franks et al., Genes Dev 2007
-
Reactome Reaction:
EXOSC2
→
XRN1
(reaction)
Chen et al., Cell 2001, Lai et al., Mol Cell Biol 2003, Raineri et al., Nucleic Acids Res 2004, Lykke-Andersen et al., Genes Dev 2005, Hau et al., J Cell Biochem 2007, Franks et al., Genes Dev 2007
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
MIPS CORUM mRNA decay complex (UPF1, UPF2, UPF3B, DCP2, XRN1, XRN2, EXOSC2, EXOSC4, EXOSC10, PARN):
mRNA decay complex (UPF1, UPF2, UPF3B, DCP2, XRN1, XRN2, EXOSC2, EXOSC4, EXOSC10, PARN) complex (DCP2-EXOSC10-EXOSC2-EXOSC4-PARN-UPF1-UPF2-UPF3B-XRN1-XRN2)
Lejeune et al., Mol Cell 2003
-
IRef Corum Interaction:
Complex of 11 proteins
(association, coimmunoprecipitation)
Lejeune et al., Mol Cell 2003
-
IRef Intact Interaction:
Complex of EIF4A3-DCP1A-EXOSC2-SMG1-GSPT1-XRN1-UPF1
(association, anti tag coimmunoprecipitation)
Isken et al., Cell 2008
Text-mined interactions from Literome
Ingham et al., Mol Microbiol 1999
:
Rho was not
involved in bulk
mRNA decay in B. subtilis
Barnhart et al., J Immunol 2000
:
CD154 expression is
regulated throughout a time course of CD3 dependent T cell activation by differential
mRNA decay
Bond et al., Mol Cell Biol 2001
:
We propose a unifying model in which
Dbp2p affects both nonsense mediated
mRNA decay and rRNA processing by altering rRNA structure, allowing specific processing events in one instance and facilitating dissociation of the translation termination complex in the other
Maillet et al., J Biol Chem 2002
:
Taken together, our results suggest that the
Ccr4-Not complex , via the N-terminal region of Not1p, is
necessary for the maintenance of stable cellular levels of Dhh1p and Caf1p, thus contributing to regulation of
mRNA decay in addition to transcription
Bollig et al., Biochem Biophys Res Commun 2003
:
The selective interaction with an ARE containing RNA and the phosphorylation by MK2 suggest that
PABP1 plays a regulatory role in ARE dependent
mRNA decay and its modulation by the p38 MAP kinase cascade
Smith et al., J Gen Virol 2003
(Herpes Simplex) :
This paper examines whether
RNase L , a virally induced endoribonuclease,
contributes to HSV induced
mRNA decay
Long et al., Mol Cell 2003
:
In yeast, Dcp1p, Dcp2p,
Lsm1-7p , and Xrn1p are
required for
mRNA decay and are localized within discrete cytoplasmic foci ; in the May 2 issue of Science, Sheth and Parker provide compelling evidence that these foci represent sites for mRNA decay ... In yeast, Dcp1p,
Dcp2p , Lsm1-7p, and Xrn1p are
required for
mRNA decay and are localized within discrete cytoplasmic foci ; in the May 2 issue of Science, Sheth and Parker provide compelling evidence that these foci represent sites for mRNA decay ... In yeast,
Dcp1p , Dcp2p, Lsm1-7p, and Xrn1p are
required for
mRNA decay and are localized within discrete cytoplasmic foci ; in the May 2 issue of Science, Sheth and Parker provide compelling evidence that these foci represent sites for mRNA decay ... In yeast, Dcp1p, Dcp2p, Lsm1-7p, and
Xrn1p are
required for
mRNA decay and are localized within discrete cytoplasmic foci ; in the May 2 issue of Science, Sheth and Parker provide compelling evidence that these foci represent sites for mRNA decay
Takahashi et al., EMBO J 2003
:
Interaction between Ski7p and
Upf1p is
required for nonsense mediated 3'-to-5 '
mRNA decay in yeast
Uchida et al., J Biol Chem 2004
:
Consistent with the
roles of
hPan2 and hPan3 in
mRNA decay , the two subunits exhibit cytoplasmic co-localization ... Consistent with the
roles of hPan2 and
hPan3 in
mRNA decay , the two subunits exhibit cytoplasmic co-localization
Shibuya et al., Nature structural & molecular biology 2004
:
In mammalian cells,
eIF4AIII is
essential for nonsense mediated
mRNA decay ( NMD )
Gherzi et al., Mol Cell 2004
:
Thus,
KHs promote rapid
mRNA decay by recruiting degradation machinery to ARE containing mRNAs
Yang et al., J Biol Chem 2004
:
Endonuclease mediated
mRNA decay requires tyrosine phosphorylation of
polysomal ribonuclease 1 (PMR1) for the targeting and degradation of polyribosome bound substrate mRNA
Unterholzner et al., Mol Cell 2004
:
In contrast, SMG5 requires
SMG7 to
trigger mRNA decay and to localize to decay bodies
Ogilvie et al., J Immunol 2005
:
We hypothesized that the ARE binding protein
tristetraprolin (TTP) regulates T lymphocyte IL-2
mRNA decay by interacting with the IL-2 ARE and targeting the transcript for decay
Lykke-Andersen et al., Genes Dev 2005
:
TTP and
BRF-1 each contain two activation domains that can activate mRNA decay after fusion to a heterologous RNA binding protein, and
inhibit ARE mediated
mRNA decay when overexpressed ...
TTP and BRF-1 each contain two activation domains that can activate mRNA decay after fusion to a heterologous RNA binding protein, and
inhibit ARE mediated
mRNA decay when overexpressed
Bonafé et al., Cancer Res 2005
(Ovarian Neoplasms) :
These data suggest that
GAPDH binding to CSF-1 ARE sequence
prevents CSF-1
mRNA decay and subsequent down-regulation of CSF-1 protein translation, leading to CSF-1 overexpression and increased metastatic properties seen in ovarian cancer
Culbertson et al., RNA 2005
:
In Saccharomyces cerevisiae, nonsense mediated
mRNA decay ( NMD )
requires Upf1p , Upf2p, and Upf3p to accelerate the decay rate of two unique classes of transcripts : ( 1 ) nonsense mRNAs that arise through errors in gene expression, and ( 2 ) naturally occurring transcripts that lack coding errors but have built-in features that target them for accelerated decay ( error-free mRNAs )
Khan et al., Carcinogenesis 2006
(Xeroderma Pigmentosum) :
This reduced XPC mRNA level in cells from XP-C patients was caused by the
PTC that
induces nonsense mediated
mRNA decay
Gaba et al., Mol Cell 2005
:
CPA1 expression is also
controlled by nonsense mediated
mRNA decay ( NMD )
Yamashita et al., Biochim Biophys Acta 2005
:
The
role of
SMG-1 in nonsense mediated
mRNA decay
Kwak et al., J Biol Chem 2006
:
Our results indicate that mPer3 3'-UTR mediated
mRNA decay plays an essential role in mRNA
cycling and provide direct evidence for post-transcriptional control of circadian mRNA oscillations
Goldstrohm et al., Nature structural & molecular biology 2006
:
We suggest that the
PUF-Pop2p interaction underlies
regulated deadenylation,
mRNA decay and repression by PUF proteins
Lee et al., Neurobiol Dis 2006
(Disease Models, Animal...) :
Suppression of
galactosylceramidase (GALC) expression in the twitcher mouse model of globoid cell leukodystrophy ( GLD ) is
caused by nonsense mediated
mRNA decay ( NMD )
Seko et al., Autoimmun Rev 2006
(Autoimmune Diseases) :
Cytokine
mRNA decay is
dependent not only upon
cis-elements in the RNA but also upon trans acting factors such as the RNA binding proteins TTP, HuR, AUF-1, Nucleolin and YB-1
Arciga-Reyes et al., Plant J 2006
:
UPF1 is
required for nonsense mediated
mRNA decay ( NMD ) and RNAi in Arabidopsis
Jang et al., J Biol Chem 2006
:
In addition,
Rbp1p mediated porin
mRNA decay is elicited by Xrn1p, a 5 ` to 3 ` exonuclease
He et al., EMBO J 2006
:
AUF1 proteins bind the ARE, undergo shuttling, and
promote cytoplasmic
ARE-mRNA decay through a poorly understood mechanism
Huertas et al., Mol Cell Biol 2006
:
The lack of a functional
THO complex impairs transcription, leads to transcription dependent hyperrecombination,
causes mRNA export defects and fast
mRNA decay , and retards replication fork progression in a transcription dependent manner
Benjamin et al., Mol Cell Biol 2006
:
BRF1 protein turnover and
mRNA decay activity are
regulated by
protein kinase B at the same phosphorylation sites
Mohanty et al., Nucleic Acids Res 2006
:
Polyadenylation of RNAs by poly ( A ) polymerase I ( PAP I ) in Escherichia coli
plays a significant role in
mRNA decay and general RNA quality control
Hau et al., J Cell Biochem 2007
:
A 31 nucleotide ARE sequences from the TNF-alpha 3 ' UTR promoted
TTP dependent
mRNA decay when it was inserted into the 3 ' UTR of a beta-globin reporter transcript, indicating that this short sequence was sufficient for TTP function
Urban et al., Nucleic Acids Res 2007
:
We found that translational regulation by these sRNAs was largely independent of full-length RNase E, e.g. despite the fact that ompA fusion
mRNA decay could no longer be
promoted by
MicA
Behm-Ansmant et al., EMBO J 2007
:
A conserved
role for cytoplasmic
poly(A) binding protein 1 ( PABPC1 ) in nonsense mediated
mRNA decay
Peng et al., Mol Cell 2007
:
c-Src activates endonuclease mediated
mRNA decay ... Similarly, only active
c-Src induces PMR1 mediated
mRNA decay
Morris et al., EMBO Rep 2007
:
Human
INT6/eIF3e is
required for nonsense mediated
mRNA decay
Stojic et al., BMC molecular biology 2007
:
While inhibition of nonsense mediated
mRNA decay selectively
stabilized ABCC5_SV1 but not ABCC5_SV2, the amount of full length ABCC5 mRNA was simultaneously reduced
Deleault et al., Mol Immunol 2008
(MAP Kinase Signaling System) :
These data establish that
TTP mediated TNF-alpha
mRNA decay is inhibited by the combined activation of ERK and p38 and not by p38 activation alone
Yamasaki et al., J Biol Chem 2007
:
Tethering
TIA-1 to a reporter transcript also
promotes mRNA decay , suggesting that TIA-1 mediated translational silencing can render mRNA susceptible to the decay machinery
Simón et al., Nucleic Acids Res 2007
:
Overall, our results demonstrate a direct
involvement of
Pab1 in
mRNA decay and reveal the modular nature of this factor, with different domains affecting various cellular processes
Luke et al., Nucleic Acids Res 2007
:
Saccharomyces cerevisiae
Ebs1p is a putative ortholog of human Smg7 and
promotes nonsense mediated
mRNA decay
Müller et al., J Cell Biol 2007
:
Histone
mRNA decay does not
require Chk1/Chk2
Meaux et al., Mol Cell 2008
:
Nonsense mediated
mRNA decay in yeast does not
require PAB1 or a poly ( A ) tail
Zhu et al., RNA Biol 2008
:
In this article, we will review the work to date in understanding the mechanisms by which
ZAP promotes viral
mRNA decay and discuss future research directions to further investigate the function and underlying mechanisms of ZAP
Woo et al., Nucleic Acids Res 2009
:
This report on the regulation of mper2 proposes that post-transcriptional
mRNA decay mediated by
PTB is a fine tuned regulatory mechanism that includes dampening-down effects during circadian mRNA oscillations
Gong et al., Genes Dev 2009
:
UPF1 functions in both
Staufen 1 (STAU1) mediated
mRNA decay ( SMD ) and nonsense mediated mRNA decay ( NMD ), which we show here are competitive pathways
Ogilvie et al., J Biol Chem 2009
:
Tristetraprolin mediates interferon-gamma
mRNA decay
Vignier et al., Circ Res 2009
(Disease Models, Animal...) :
Nonsense mediated
mRNA decay and ubiquitin-proteasome system
regulate cardiac
myosin binding protein C mutant levels in cardiomyopathic mice
Sanduja et al., Aging 2009
(Uterine Cervical Neoplasms) :
It was found that
TTP promoted rapid
mRNA decay of the cellular ubiquitin ligase E6-associated protein ( E6-AP )
Zhou et al., Nucleic Acids Res 2010
(Prostatic Neoplasms) :
Here we show that
EBP1 promoted AR
mRNA decay through physical interaction with a conserved UC-rich motif within the 3'-UTR of AR
Burnicka-Turek et al., BMC cell biology 2010
:
Recent studies revealed the essential
role of
PELO in the No-Go
mRNA decay , by which mRNA with translational stall are endonucleotically cleaved and degraded
Temme et al., RNA 2010
:
Overexpression of catalytically dead
CAF1 had a dominant negative effect on
mRNA decay
Li et al., RNA 2011
:
Using mouse embryonic fibroblast (MEF) cell lines derived from a hypomorphic knockout of the Dcp2 gene with undetectable levels of Dcp2 or MEF cell lines harboring a Nudt16 directed shRNA to generate reduced levels of Nudt16, we demonstrate the distinct
roles for
Dcp2 and Nudt16 in nonsense mediated
mRNA decay ( NMD ), decay of ARE containing mRNA and miRNA mediated silencing ... Using mouse embryonic fibroblast (MEF) cell lines derived from a hypomorphic knockout of the Dcp2 gene with undetectable levels of Dcp2 or MEF cell lines harboring a Nudt16 directed shRNA to generate reduced levels of Nudt16, we demonstrate the distinct
roles for Dcp2 and
Nudt16 in nonsense mediated
mRNA decay ( NMD ), decay of ARE containing mRNA and miRNA mediated silencing
Sanduja et al., Wiley Interdiscip Rev RNA 2011
(Inflammation...) :
The
roles of
TTP and BRF proteins in regulated
mRNA decay ... The
roles of TTP and
BRF proteins in regulated
mRNA decay
Jinek et al., Mol Cell 2011
:
Coupled 5 ' nucleotide recognition and processivity in
Xrn1 mediated
mRNA decay
Sugiyama et al., J Biochem 2011
:
Here, we report that the interaction between
Mrt4 and Yvh1 is also
essential for normal glycogen accumulation and
mRNA decay as well as the induction of sporulation genes IME2, SPO13 and HOP1
Lin et al., J Cell Biol 2011
:
Here we show that down-regulation of
PTB and its neuronal analogue nPTB during muscle cell differentiation may
involve alternative splicing coupled nonsense mediated
mRNA decay
Lin et al., Mol Cell Biol 2011
(Herpes Simplex...) :
Here we show that mouse embryonic fibroblasts derived from knockout mice deficient in KH-type splicing regulatory protein ( KSRP ), an RNA binding protein required for ARE mediated mRNA decay, produce higher levels of
Ifna and Ifnb mRNAs in response to viral infection as a
result of decreased
mRNA decay ... Here we show that mouse embryonic fibroblasts derived from knockout mice deficient in KH-type splicing regulatory protein ( KSRP ), an RNA binding protein required for ARE mediated mRNA decay, produce higher levels of Ifna and
Ifnb mRNAs in response to viral infection as a
result of decreased
mRNA decay
Kim et al., Nucleic Acids Res 2011
:
hnRNP Q mediates a phase dependent translation coupled
mRNA decay of mouse Period3 ... We propose the phase dependent translation coupled
mRNA decay mediated by
hnRNP Q as a new regulatory mechanism of the rhythmically regulated decay of mPer3 mRNA
Challagundla et al., Mol Cell Biol 2011
:
Ablation of Ago2 abrogated the L11 mediated reduction of c-myc mRNA, whereas knockdown of L11 rescued
miR-24 mediated c-myc
mRNA decay
Carroll et al., J Cell Biol 2011
:
Whereas
Dhh1 's ATPase activity was not
required to induce translational inhibition and
mRNA decay when directly tethered to an mRNA, ATP hydrolysis regulated processing body dynamics and the release of Dhh1 from these RNA-protein granules ... Whereas Dhh1 's
ATPase activity was not
required to induce translational inhibition and
mRNA decay when directly tethered to an mRNA, ATP hydrolysis regulated processing body dynamics and the release of Dhh1 from these RNA-protein granules
Gherzi et al., Wiley Interdiscip Rev RNA 2010
:
The
role of
KSRP in
mRNA decay and microRNA precursor maturation
Gratacós et al., Wiley Interdiscip Rev RNA 2010
:
The
role of
AUF1 in regulated
mRNA decay
Chang et al., Nucleic Acids Res 2012
:
Here, we show that
Dhh1p can associate with POR1 mRNA and specifically
promote POR1
mRNA decay via its interaction with Rbp1p ... Interestingly, this non conserved C-terminal region of Dhh1p is required for interaction with Rbp1p and modulating
Rbp1p mediated POR1
mRNA decay ... Moreover, mammalian DDX6 became capable of interacting with Rbp1p and could confer
Rbp1p mediated POR1
mRNA decay in the dhh1d strain upon fusion to the C-terminal unique region of Dhh1p
Young et al., Mol Cancer Res 2012
(Carcinoma...) :
We identified miR-16 to bind the COX-2 3'-UTR and
inhibit COX-2 expression by promoting rapid
mRNA decay
Masuda et al., Scientific reports 2012
:
Role of
CUGBP1 on accelerated
mRNA decay has been previously reported, but the similar function of MBNL1 has not been reported to date
Mocquet et al., J Virol 2012
:
The human T-lymphotropic virus type 1 tax protein
inhibits nonsense mediated
mRNA decay by interacting with
INT6/EIF3E and UPF1 ... The human T-lymphotropic virus type 1 tax protein
inhibits nonsense mediated
mRNA decay by interacting with INT6/EIF3E and
UPF1
Chujo et al., Nucleic Acids Res 2012
:
LRPPRC/SLIRP suppresses PNPase mediated
mRNA decay and promotes polyadenylation in human mitochondria ...
LRPPRC/SLIRP suppresses PNPase mediated
mRNA decay and promotes polyadenylation in human mitochondria
Al-Haj et al., Nucleic Acids Res 2012
:
Indeed, we found that
RNase L promotes tristetraprolin ( TTP/ZFP36 )
mRNA decay ... The
TTP regulation of p21
mRNA decay required functional AU-rich elements
Liu et al., Int J Biochem Cell Biol 2012
(Calcium Signaling) :
The reduction in TTP-KH-type splicing regulatory protein ( KSRP ) complexes formation promoted
KSRP mediated MMP-2/MMP-9
mRNA decay in CIL-102 treated K562 cells
Zhu et al., EMBO J 2012
:
Translational repression precedes and is required for
ZAP mediated
mRNA decay
Nakamura et al., Nature communications 2012
:
Preferential decay of Cerl2 mRNA on the left is initiated by the leftward flow and further enhanced by the operation of Wnt-Cerl2 interlinked feedback loops, in which
Wnt3 upregulates Wnt3 expression and
promotes Cerl2
mRNA decay , whereas Cerl2 promotes Wnt degradation
Liu et al., Carcinogenesis 2013
(Leukemia) :
Moreover,
TTP overexpression
increased TNF-a
mRNA decay in HQ-treated cells
Yamashita et al., Genes Cells 2013
:
Role of
SMG-1 mediated Upf1 phosphorylation in mammalian nonsense mediated
mRNA decay
Woo et al., Mol Cell Proteomics 2013
:
Through interaction with the CSF-1 3'UTR miRNA common target, we find that miR-130a and miR-301a
inhibit CSF-1 expression by enhancing
mRNA decay
Ochs et al., J Proteome Res 2013
:
Recently, we have demonstrated that
5-LO mRNA expression is
regulated by alternative splicing and nonsense mediated
mRNA decay ( NMD )
Leppek et al., Cell 2013
(Inflammation) :
Roquin promotes constitutive
mRNA decay via a conserved class of stem-loop recognition motifs
Jin et al., Gene 2013
(Mucopolysaccharidosis II) :
In addition, qRT-PCR products from the two patients showed a reduced
IDS mRNA expression ( 43.9 % and 71.2 %, respectively ), when compared with the average IDS mRNA expression in healthy control samples, possibly as a
result of nonsense mediated
mRNA decay
Al-Khalaf et al., PloS one 2013
:
p16(INK4A) Positively Regulates p21 ( WAF1 ) Expression by suppressing
AUF1 dependent
mRNA decay
Lee et al., Proc Natl Acad Sci U S A 1995
:
Double disruptions of UPF1 and
UPF3 affect nonsense
mRNA decay in a manner indistinguishable from single disruptions ... Double disruptions of
UPF1 and UPF3
affect nonsense
mRNA decay in a manner indistinguishable from single disruptions
Czaplinski et al., RNA 1995
:
Based on these results, the
role of
Upf1p 's biochemical activities in
mRNA decay and translation are discussed
Peltz et al., Genes Dev 1993
:
Using amber ( UAG ) mutants of the yeast PGK1 gene as a model system, we find that nonsense mediated
mRNA decay is position
dependent , that is, nonsense mutations within the initial two-thirds of the PGK1 coding region accelerate the decay rate of the
PGK1 transcript < or = 12-fold, whereas nonsense mutations within the carboxy-terminal third of the coding region have no effect on mRNA decay
Babitzke et al., J Bacteriol 1993
:
In addition, these results indicate that
RNase III is probably not
required for general
mRNA decay
DeMaria et al., J Biol Chem 1996
:
These results support a
role for
AUF1 in ARE directed
mRNA decay that is based upon its affinity for different AREs
Weng et al., Mol Cell Biol 1996
:
On the basis of these results, the
role of the
Upf complex in nonsense mediated
mRNA decay and nonsense suppression is discussed
Matsunaga et al., Mol Microbiol 1996
:
Moreover, mutations in rncO that block RNase III cleavage also block control, showing that
RNase III initiates
mRNA decay by cleaving at a single site
Ingle et al., Proc Natl Acad Sci U S A 1996
:
Exogenously added
PAP I does not
restore mRNA decay to PAP I-polysomes, suggesting that, in vivo, PAP I may be part of a multiprotein complex
Cruz et al., FEMS Microbiol Lett 1996
:
A new
role for
RNase II in
mRNA decay : striking differences between RNase II mutants and similarities with a strain deficient in RNase E
He et al., Mol Cell Biol 1997
:
We showed previously that
Upf1p and Nmd2p interact and that this interaction is
required for nonsense mediated
mRNA decay ( F
Christiano et al., J Invest Dermatol 1997
(Epidermolysis Bullosa Dystrophica) :
Premature termination codon mutations in the type VII collagen gene in recessive dystrophic
epidermolysis bullosa result in nonsense mediated
mRNA decay and absence of functional protein
Shirley et al., J Cell Sci 1998
:
In Saccharomyces cerevisiae,
Upf3p is
required for nonsense mediated
mRNA decay ( NMD )
Mangus et al., Mol Cell Biol 1998
:
The suppression of pab1Delta by pbp1Delta appears to be different from that mediated by other pab1 suppressors, since disruption of
PBP1 does not alter translation rates, affect accumulation of ribosomal subunits, change mRNA poly ( A ) tail lengths, or
result in a defect in
mRNA decay