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DUSP6 — FGF8

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Vieira et al., Brain research. Brain research reviews 2005 : Ectopically, expression of Fgf8 protein induces Mkp3 in a short period of time in the diencephalon, indicating a positive regulation of Mkp3 by Fgf8
Ekerot et al., Biochem J 2008 : Negative-feedback regulation of FGF signalling by DUSP6/MKP-3 is driven by ERK1/2 and mediated by Ets factor binding to a conserved site within the DUSP6/MKP-3 gene promoter ... DUSP6/MKP-3 is inducible by FGF ( fibroblast growth factor ) signalling and acts as a negative regulator of ERK activity in key and discrete signalling centres that direct outgrowth and patterning in early vertebrate embryos ... In the present study, we demonstrate, using pharmacological inhibitors and analysis of the murine DUSP6/MKP-3 gene promoter, that the ERK pathway is critical for FGF induced DUSP6/MKP-3 transcription
Uejima et al., Dev Growth Differ 2010 : Manipulated overdose of fibroblast growth factor ( FGF ) in the presumptive digit 2 region of chick forelimb bud results in elongation of cartilage elements of digit 2, suggesting that attenuated FGF signaling, which Mkp3 , Sef, and TSK negatively regulate , provides digit 2-specific traits of morphology