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FOS — MMP9
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Westermarck et al., FASEB J 1999
(Neoplasm Invasiveness...) :
This review will summarize the current view on the role of MMPs in tumor growth, invasion, and survival, and focus on the
role of mitogen activated protein kinases and
AP-1 and ETS transcription factors in the regulation of
MMP gene expression during invasion process
Crowe et al., Neoplasia (New York, N.Y.) 1999
(Carcinoma, Squamous Cell...) :
To determine how a specific
AP-1 family member, c-fos,
regulates MMP-9 promoter activity through these sites, we used an expression vector containing the c-fos coding region fused to the estrogen receptor ( ER ) ligand binding domain
Yan et al., J Biol Chem 2001
(Neoplasm Invasiveness) :
Although
MMP-9 expression is
regulated by
AP-1 , Sp1, and Ets transcription factors, KiSS-1 did not alter the binding of these factors to the MMP-9 promoter
Troussard et al., Oncogene 2000
(Glioblastoma) :
These data demonstrate that ILK can induce an invasive phenotype via
AP-1 dependent upregulation of
MMP-9
Takahra et al., Int J Biochem Cell Biol 2004
:
Induction of myofibroblast
MMP-9 transcription in three-dimensional collagen I gel cultures : regulation by NF-kappaB,
AP-1 and Sp1
Gebbia et al., J Infect Dis 2004
:
Analysis of nuclear extracts indicated that activator protein (AP)-1 was reduced in TLR2 neutralized monocytic cells, suggesting that
AP-1 plays a role in the transcriptional activation of
MMP-9 through TLR2
Chung et al., FASEB J 2004
(MAP Kinase Signaling System...) :
Furthermore, we have shown that enhanced expression of
MMP-9 in HBx transfected cells
mediated by not only activation of
AP-1 transcriptional activity through ERKs pathway but also activation of NF-kappaB transcriptional activity through PI-3K-AKT/PKB pathway, and was associated with the invasive potential
Cooper et al., Toxicol Appl Pharmacol 2004
:
Arsenite stimulated MAP kinase signal transduction resulted in increased production of
matrix metalloproteinase (MMP)-9 , an
AP-1 regulated gene product
Hong et al., J Biol Chem 2005
:
Reporter gene, electrophoretic mobility shift, kinase inhibitor assays, and in vitro kinase assay showed that ascochlorin
inhibits MMP-9 gene expression by suppressing activation of the nuclear transcription factor
activator protein-1 (AP-1) via the extracellular signal regulated kinase 1 and 2 pathway ... In conclusion, ascochlorin represents a unique natural anti-tumor compound that specifically inhibits MMP-9 activity through suppression of
AP-1 dependent
induction of
MMP-9 gene expression
Chandrasekar et al., J Biol Chem 2006
(Atherosclerosis) :
Ectopic expression of p65,
c-Fos , c-Jun, and Fra-1
induced MMP9 promoter activity
Kroczynska et al., Proc Natl Acad Sci U S A 2006
(Mesothelioma) :
Ap-1 activity
caused the expression and activation of matrix metalloprotease (MMP)-1 and
MMP-9 , which in turn led to cell invasion
Cho et al., Carcinogenesis 2007
(MAP Kinase Signaling System) :
Furthermore, as evidenced by MMP-9 promoter and electrophoretic mobility shift assays, ascofuranone specifically
inhibited MMP-9 gene expression by blocking PMA stimulated activation of
activator protein-1 (AP-1)
Kajanne et al., J Cell Physiol 2007
:
Here we provide genetic and biochemical evidence that EGF-R- and
AP-1 mediated signals are
required for
MMP expression and collagen contraction in fibroblasts
Lee et al., Cardiovasc Res 2007
:
Down-regulation of NQO1
inhibits MMP-9 gene expression by suppressing activation of nuclear factor-kappa B (NF-kappaB) and
activator protein-1 (AP-1) , well-known key elements mediating MMP-9 gene expression in its promoter, via the p38 MAPK and JNK pathways
Oliver et al., J Rheumatol 2007
(Arthritis, Experimental...) :
We evaluated whether a vanadium
AP-1 inhibitor could
reduce MMP expression and subsequent joint damage in CIA
Srivastava et al., J Biol Chem 2007
:
Overexpression of a dominant negative inhibitor of NF-kappaB or
AP-1 blocked the TNF-alpha induced expression of
MMP-9 in myotubes ... Furthermore, overexpression of a dominant negative mutant of TAK1 blocked the TNF-alpha induced expression of
MMP-9 and
activation of NF-kappaB and
AP-1
Lin et al., Carcinogenesis 2008
(Breast Neoplasms...) :
A translocation of protein kinase C (PKC)delta from the cytosol to the membrane followed by activation of extracellular signal regulated kinase ( ERK ) and c-Jun/activator protein-1 (AP-1) by TPA was demonstrated, and TPA induced
MMP-9 activation and migration were
inhibited by the pan PKC inhibitor, GF109203X, the specific PKCdelta inhibitor, rottlerin, an ERK inhibitor ( PD98059 ) and an
AP-1 inhibitor ( curcumin )
Wang et al., Glia 2009
(MAP Kinase Signaling System) :
The
regulation of
MMP-9 gene transcription by
AP-1 was confirmed by oxLDL stimulated MMP-9 luciferase activity which was totally lost in cells transfected with the AP-1 binding site mutated MMP-9 promoter construct ( mt-AP1-MMP-9 )
Ahn et al., Biochem Biophys Res Commun 2008
:
These results suggest that TGase 2
inhibits MMP-9 via downregulation of MMP-9 transcription activity by blocking the binding of the Jun-fos complex to an
AP-1 site
Hasegawa et al., Exp Cell Res 2009
(Neoplasm Invasiveness) :
To assess the role of AP-1 function, we examined the
effects of dominant negative
Fos ( DeltaFos ), BATF and siRNA against c-Jun on
MMP production in v-Crk transformed cells which have augmented production of MMP-2 and MMP-9
Zhang et al., J Surg Res 2009
:
AP-1 inhibits expression of
MMP-2/9 and its effects on rat smooth muscle cells
Lin et al., Cell Signal 2009
:
These results suggested that in A549 cells, the activation of p42/p44 MAPK, p38 MAPK, JNK1/2, NF-kappaB, and
AP-1 are
essential for the IL-1 beta induced
MMP-9 gene expression and cell migration
Kim et al., Neurochem Int 2010
(Parkinson Disease) :
These results collectively suggest that ROS, PI3 kinase, NF-kappaB, and
AP-1 are commonly
involved in 6-OHDA- and MPP ( + ) -induced
MMP-9 gene expression, and that p38 MAPK is differentially involved
Park et al., Mol Cells 2010
(MAP Kinase Signaling System...) :
Melittin suppresses PMA induced tumor cell invasion by inhibiting NF-kappaB and
AP-1 dependent
MMP-9 expression ... Furthermore, as evidenced by MMP-9 promoter assays, melittin
inhibited MMP-9 gene expression by blocking the PMA stimulated activations of
activator protein-1 (AP-1) and nuclear factor-kappa B (NF-kappaB)
Kim et al., Immunopharmacol Immunotoxicol 2010
(Breast Neoplasms) :
The results of promoter assay and EMSA showed that HM specifically
inhibits MMP-9 gene expression by blocking PMA stimulated activation of
activator protein-1 (AP-1) ... These results indicate that HM
inhibits PMA induced
MMP-9 expression by blocking the activation of
activator protein-1 (AP-1) via extracellular signal regulated kinase 1/2 ( ERK 1/2 ) signaling pathway
Murthy et al., J Biol Chem 2010
(MAP Kinase Signaling System...) :
Deletion and mutational analysis of the MMP-9 promoter revealed that both SP-1 and
AP-1 are
essential for
MMP-9 transcription
Speidl et al., FASEB J 2011
(Plaque, Atherosclerotic) :
In addition, blocking experiments revealed that MMP-1 expression was mediated by activation of the transcription factor AP-1, and
MMP-9 expression was
induced by activation of NF-?B and
AP-1
Reddy et al., J Cell Physiol 2011
(Hyperplasia) :
WISP1 also activated
AP-1 , but not NF-?B, and
induced matrix metalloproteinase (MMP)9 transcription in part via AP-1
Yen et al., J Biol Chem 2011
(MAP Kinase Signaling System) :
PKA, PI3K, and ERK inhibitors abolished PGE2- and cAMP induced
c-Fos and MMP-9 up-regulation, and ERK activation was
required for the binding of activator protein 1 (AP-1) transcription factor to the
MMP-9 promoter
Yang et al., Journal of neuroinflammation 2012
:
JEV induced
MMP-9 expression and promoter activity were
inhibited by pretreatment with inhibitors of AP-1 ( tanshinone ), c-Src ( PP1 ), PDGFR ( AG1296 ), and PI3K ( LY294002 ), and by transfection with siRNAs of c-Jun,
c-Fos , PDGFR, and Akt ... From these results, we conclude that JEV activates the ROS/c-Src/PDGFR/PI3K/Akt/MAPKs pathway, which in turn triggers
AP-1 activation and ultimately
induces MMP-9 expression in RBA-1 cells
Valente et al., J Mol Cell Cardiol 2012
(Cardiomegaly...) :
Here we report that Ang-II induced CIKS mRNA and protein expression, CIKS binding to IKK and JNK perhaps functioning as a scaffold protein, CIKS dependent IKK/NF-?B and JNK/AP-1 activation, p65 and c-Jun phosphorylation and nuclear translocation, NF-?B- and
AP-1 dependent IL-18 and
MMP-9 induction , and hypertrophy of adult cardiomyocytes isolated from WT, but not CIKS-null mice
Valente et al., Am J Physiol Heart Circ Physiol 2012
(Hyperplasia) :
ANG II-induced superoxide generation, NF-?B and
AP-1 activation, and IL-18 and
MMP-9 induction were all markedly attenuated by losartan, diphenyleneiodonium chloride ( DPI ), and Nox1 knockdown
Hsieh et al., Journal of neuroinflammation 2012
:
These results demonstrated that in RBA-1 cells, activation of
ATF2/AP-1 by the PKC ( a ) -mediated Nox ( 2 ) /ROS signals is
essential for upregulation of
MMP-9 and cell migration enhanced by LTA
Zhan et al., Exp Cell Res 2012
(Neoplasm Invasiveness...) :
In addition, inhibition of
activator protein-1 (AP-1) reduced MMP-1,
MMP-9 and MMP-12 gene expression
Kim et al., Mol Biol Rep 2012
(Lung Neoplasms...) :
These results indicate that resveratrol inhibits both NF-?B and
AP-1 mediated
MMP-9 expression, leading to suppression of migration and invasion of human metastatic lung and cervical cancer cells
Choi et al., Int Immunopharmacol 2012
:
Luciferase activity assays and electrophoretic mobility shift assays using RAW264.7 cells showed that the inhibition of
MMP-9 expression by aesculin was
mediated by
AP-1 rather than NF-?B
Lin et al., Cell communication and signaling : CCS 2012
:
These results demonstrated that in RBA-1 cells, activation of
AP-1 ( c-Fos/c-Jun ) by the PKC-a mediated Nox2/ROS signals is
essential for up-regulation of
MMP-9 and cell migration enhanced by BK
Tseng et al., PloS one 2013
:
These results suggested that NF-?B and
AP-1 activated by JNK1/2 and p42/p44 MAPK cascade are
involved in IL-1ß induced
MMP-9 expression in SIRCs
Kuzniewska et al., Mol Cell Biol 2013
:
The BDNF induced
MMP-9 transcription was
dependent on extracellular signal regulated kinase 1/2 ( ERK1/2 ) pathway and
c-Fos expression
Khoi et al., Int J Oncol 2013
:
Studies with expression vectors encoding mutated NF-?B signaling molecules and AP-1 decoy confirmed that NF-?B and
AP-1 were
essential for the nicotine stimulated
MMP-9 expression
Sato et al., J Biol Chem 1993
:
Binding sites for NF-kB, Sp-1, and
AP-1 are reportedly
required for induction of
MMP-9 gene expression by tumor necrosis factor-alpha or 12-O-tetradecanoylphorbol-13-acetate
Yoshizaki et al., Proc Natl Acad Sci U S A 1998
(Cell Transformation, Neoplastic...) :
Here we report that binding sites for NF-kappaB, SP-1, and
AP-1 also
contribute to induction of the
MMP9 promoter by the viral protein, LMP1, mainly through the NF-kappaB and, to a lesser extent, the SP-1 and AP-1 sites
Fisher et al., J Investig Dermatol Symp Proc 1998
:
In the dermis and epidermis,
AP-1 induces expression of matrix metalloproteinases collagenase,
92 kDa gelatinase , and stromelysin, which degrade collagen and other proteins that comprise the dermal extracellular matrix