Pathways - manually collected, often from reviews:
OpenBEL Selventa BEL large corpus:
RARA
→
PPARGC1A
(directlyIncreases, PPARGC1A Activity, RARA Activity)
Evidence: UCP-1 expression is under complex regulation; an enhancer element in the 5'flanking region of the ucp-1 gene has been described with putative binding sites for the thyroid hormone receptor, retinoic acid receptors and PPARs, as recently reviewed (Rousset et al. 2004). PPARc is a nuclear receptor essential for adipogenic differentiation in both WAT and BAT (Lowell 1999), that also displays a thermogenic function upon activation, with prostaglandings being the physiological ligands and TZD pharmac...