Gene interactions and pathways from curated databases and text-mining

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ATR — TP53

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Lakin et al., Oncogene 1999 (Ataxia Telangiectasia) : The ataxia-telangiectasia related protein ATR mediates DNA dependent phosphorylation of p53
Taylor et al., Oncogene 2001 : Chk1, Chk2, Atm and Atr also contribute to the activation of p53 in response to genotoxic stress and therefore play multiple roles
Nghiem et al., J Biol Chem 2002 : ATR is not required for p53 activation but synergizes with p53 in the replication checkpoint ... Indeed, ATR-kd expression sensitized these cells to DNA damage and caused a transient decrease in damage induced serine 15 phosphorylation of p53
Zhang et al., J Biol Chem 2002 (Ataxia Telangiectasia...) : On the other hand, UVC induced apoptosis occurs through ATR dependent p53 phosphorylation as well as the JNK pathway
Hammond et al., Mol Cell Biol 2002 : Inhibition of ATR kinase activity substantially reduces hypoxia induced phosphorylation of p53 protein on serine 15 as well as p53 protein accumulation
Huang et al., Oncogene 2003 : This is partly explained by the ability of the kinase inhibitor to inhibit ATM or ATR activities in vitro and impair ATM- or ATR dependent p53 phosphorylation in vivo
Hammond et al., Mutat Res 2003 : We have shown previously that hypoxia induces ATR dependent phosphorylation of p53 , Chk1 and histone H2AX
Zhu et al., Mol Cell Biol 2004 : CDK2 inhibition triggers a p53-p21 response via ATM- and ATR dependent p53 phosphorylation at serine 15
Caporali et al., Mol Pharmacol 2004 : ATR was activated earlier than ATM and was required for an efficient phosphorylation of Chk1 and p53 on Ser15
Park et al., Cell 2005 : These results suggest that p18 is a haploinsufficient tumor suppressor and a key factor for ATM/ATR mediated p53 activation
Kim et al., Mol Cell Biol 2005 : The arrest is independent of p53 activation by ATM or ATR and does not involve heightened expression of p21
Rocha et al., EMBO J 2005 : Significantly, ATR activity is also required for ARF induced p53 activity and inhibition of proliferation
Rocha et al., Cell cycle (Georgetown, Tex.) 2005 : Furthermore, ARF induced ATR is required for efficient induction and activation of p53
Kumar et al., Cell cycle (Georgetown, Tex.) 2005 (Leukemia, Myeloid) : p53 induction in ML-1 cells was ATR dependent and downregulation of p53 through RNAi delayed HU-induced apoptosis
Tomimatsu et al., J Biol Chem 2007 : Using ATM/Ku70 double-null cell lines, which we generated, we confirmed that ATM independent ATR activity contributed to persistent phosphorylation of p53 ( Ser18 ) in Ku-deficient cells at 12 h post ionizing radiation
Gao et al., Mol Pharmacol 2008 : This study provides new insights into the requirement of genotoxicity for DMBA induced immunosuppression in vivo and highlights the roles of ATM/ATR in signaling p53
Zhang et al., J Cell Sci 2007 (Osteosarcoma) : The increase of cell-membranous phosphatidylcholines containing polyunsaturated fatty acid residues induces phosphorylation of p53 through activation of ATR ... We further demonstrate that the PCs with linoleic acid in their sn-2 position ( 18 : 2n6 ) induce phosphorylation of Ser15 in p53 in an ATR dependent manner
Pabla et al., J Biol Chem 2008 (Kidney Diseases...) : Importantly, in the DNA damage response, we demonstrate a critical role for ATR , but not ATM ( ataxia telangiectasia mutated ) or DNA-PK ( DNA dependent protein kinase ), in cisplatin induced p53 activation and apoptosis
Hastak et al., Proc Natl Acad Sci U S A 2008 : DNA synthesis from unbalanced nucleotide pools causes limited DNA damage that triggers ATR-CHK1 dependent p53 activation
Derheimer et al., Mol Pharmacol 2009 (Ataxia Telangiectasia) : Psoralen induced DNA interstrand cross-links block transcription and induce p53 in an ataxia-telangiectasia and rad3-related dependent manner ... The induction of p53 phosphorylation by psoralen ICLs did not require factors believed to be involved in the repair of psoralen ICLs [ xeroderma pigmentosum ( XP ) -A, XP-C, XP-F, Cockayne 's syndrome-B, Fanconi anemia ] but did require the ataxia-telangiectasia and Rad3 related but not the ataxia-telangiectasia mutated kinase
Bhattacharya et al., Cell Signal 2009 : The ATM/ATR kinase inhibitor, CGK733, blocked CPT induced p53 Ser15 phosphorylation and protected cells from CPT induced apoptosis
Pedram et al., Mol Biol Cell 2009 : We find that in estrogen receptor ( ER ) -positive breast cancer cells, UV or ionizing radiation and hydroxyurea rapidly activate ATR dependent phosphorylation of endogenous p53 and Chk1
Gáspár et al., FASEB J 2010 : These TRH effects may be mediated in part by reducing the ATM/Atr dependent phosphorylation of p53
Lindsey-Boltz et al., J Biol Chem 2009 : We find that the ATR dependent phosphorylation of Chk1, but not p53 , is strongly stimulated by Claspin
Tibbetts et al., Genes Dev 1999 : A role for ATR in the DNA damage induced phosphorylation of p53