◀ Back to TP53
ATR — TP53
Pathways - manually collected, often from reviews:
-
BioCarta atm signaling pathway:
ATR/ATRIP/ATM complex (ATR-TREX1-ATM)
→
p53/MDM2 complex (TP53-MDM2)
(modification, activates)
-
BioCarta atm signaling pathway:
ATR/ATRIP/ATM complex (ATR-TREX1-ATM)
→
p53 (TP53)
(modification, activates)
-
BioCarta cell cycle: g2/m checkpoint:
p53/MDM2 complex (TP53-MDM2)
→
ATR
(modification, collaborate)
-
BioCarta cell cycle: g2/m checkpoint:
ATR
→
p53 (TP53)
(modification, activates)
-
KEGG Cell cycle:
ATM/ATR
→
TP53
(protein-protein, phosphorylation)
-
KEGG p53 signaling pathway:
ATR
→
TP53
(protein-protein, activation)
-
NCI Pathway Database BARD1 signaling events:
p53 (TP53)
→
ATR (ATR)
(modification, collaborate)
Fabbro et al., J Biol Chem 2004*
Evidence: assay, physical interaction
-
NCI Pathway Database BARD1 signaling events:
ATR (ATR)
→
BRCA1/BARD1/p53 complex (BRCA1-BARD1-TP53)
(modification, activates)
Fabbro et al., J Biol Chem 2004*
Evidence: assay, physical interaction
-
WikiPathways Cell Cycle:
ATM/ATR
→
TP53
(activation)
Canman et al., Science 1998*
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Bind Interaction:
ATR
—
TP53
Rocha et al., EMBO J 2005*
-
IRef Bind_translation Interaction:
ATR
—
TP53
(coimmunoprecipitation)
Rocha et al., EMBO J 2005*
-
IRef Biogrid Interaction:
ATR
—
TP53
(direct interaction, enzymatic study)
Lin et al., Genes Dev 2001*
-
IRef Biogrid Interaction:
ATR
—
TP53
(direct interaction, enzymatic study)
Wang et al., Cell Death Differ 2011*
-
IRef Biogrid Interaction:
ATR
—
TP53
(direct interaction, enzymatic study)
Lakin et al., Oncogene 1999*
-
IRef Biogrid Interaction:
ATR
—
TP53
(physical association, affinity chromatography technology)
Rocha et al., EMBO J 2005*
-
IRef Biogrid Interaction:
ATR
—
TP53
(direct interaction, enzymatic study)
Dodson et al., J Biol Chem 2006*
-
IRef Biogrid Interaction:
ATR
—
TP53
(direct interaction, pull down)
Fabbro et al., J Biol Chem 2004*
-
IRef Biogrid Interaction:
ATR
—
TP53
(direct interaction, unspecified method)
Kim et al., J Biol Chem 1999
-
IRef Hprd Interaction:
TP53
—
ATR
(in vivo)
Shieh et al., Genes Dev 2000*, Sayed et al., J Biol Chem 2000, Lopez-Borges et al., Oncogene 2000*, Xie et al., J Biol Chem 2001, Latonen et al., Oncogene 2001*, Barcia et al., Arch Biochem Biophys 2002*, Giaccia et al., Genes Dev 1998*
-
IRef Hprd Interaction:
TP53
—
ATR
(in vitro)
Shieh et al., Genes Dev 2000*, Sayed et al., J Biol Chem 2000, Lopez-Borges et al., Oncogene 2000*, Xie et al., J Biol Chem 2001, Latonen et al., Oncogene 2001*, Barcia et al., Arch Biochem Biophys 2002*, Giaccia et al., Genes Dev 1998*
-
IRef Intact Interaction:
ATR
—
TP53
(phosphorylation reaction, protein kinase assay)
Dodson et al., J Biol Chem 2006*
Text-mined interactions from Literome
Lakin et al., Oncogene 1999
(Ataxia Telangiectasia) :
The ataxia-telangiectasia related protein
ATR mediates DNA dependent phosphorylation of
p53
Taylor et al., Oncogene 2001
:
Chk1, Chk2, Atm and
Atr also
contribute to the activation of
p53 in response to genotoxic stress and therefore play multiple roles
Nghiem et al., J Biol Chem 2002
:
ATR is not
required for
p53 activation but synergizes with p53 in the replication checkpoint ... Indeed,
ATR-kd expression sensitized these cells to DNA damage and
caused a transient decrease in damage induced serine 15 phosphorylation of
p53
Zhang et al., J Biol Chem 2002
(Ataxia Telangiectasia...) :
On the other hand, UVC induced apoptosis occurs through
ATR dependent
p53 phosphorylation as well as the JNK pathway
Hammond et al., Mol Cell Biol 2002
:
Inhibition of
ATR kinase activity substantially
reduces hypoxia induced phosphorylation of
p53 protein on serine 15 as well as p53 protein accumulation
Huang et al., Oncogene 2003
:
This is partly explained by the ability of the kinase inhibitor to inhibit ATM or
ATR activities in vitro and
impair ATM- or ATR dependent
p53 phosphorylation in vivo
Hammond et al., Mutat Res 2003
:
We have shown previously that hypoxia induces
ATR dependent phosphorylation of
p53 , Chk1 and histone H2AX
Zhu et al., Mol Cell Biol 2004
:
CDK2 inhibition triggers a p53-p21 response via ATM- and
ATR dependent
p53 phosphorylation at serine 15
Caporali et al., Mol Pharmacol 2004
:
ATR was activated earlier than ATM and was
required for an efficient phosphorylation of Chk1 and
p53 on Ser15
Park et al., Cell 2005
:
These results suggest that p18 is a haploinsufficient tumor suppressor and a key factor for
ATM/ATR mediated
p53 activation
Kim et al., Mol Cell Biol 2005
:
The arrest is independent of
p53 activation by ATM or
ATR and does not involve heightened expression of p21
Rocha et al., EMBO J 2005
:
Significantly,
ATR activity is also
required for ARF induced
p53 activity and inhibition of proliferation
Rocha et al., Cell cycle (Georgetown, Tex.) 2005
:
Furthermore, ARF induced
ATR is
required for efficient induction and activation of
p53
Kumar et al., Cell cycle (Georgetown, Tex.) 2005
(Leukemia, Myeloid) :
p53 induction in ML-1 cells was
ATR dependent and downregulation of p53 through RNAi delayed HU-induced apoptosis
Tomimatsu et al., J Biol Chem 2007
:
Using ATM/Ku70 double-null cell lines, which we generated, we confirmed that ATM independent
ATR activity
contributed to persistent phosphorylation of
p53 ( Ser18 ) in Ku-deficient cells at 12 h post ionizing radiation
Gao et al., Mol Pharmacol 2008
:
This study provides new insights into the requirement of genotoxicity for DMBA induced immunosuppression in vivo and highlights the
roles of
ATM/ATR in signaling
p53
Zhang et al., J Cell Sci 2007
(Osteosarcoma) :
The increase of cell-membranous phosphatidylcholines containing polyunsaturated fatty acid residues
induces phosphorylation of
p53 through activation of
ATR ... We further demonstrate that the PCs with linoleic acid in their sn-2 position ( 18 : 2n6 ) induce phosphorylation of Ser15 in
p53 in an
ATR dependent manner
Pabla et al., J Biol Chem 2008
(Kidney Diseases...) :
Importantly, in the DNA damage response, we demonstrate a critical
role for
ATR , but not ATM ( ataxia telangiectasia mutated ) or DNA-PK ( DNA dependent protein kinase ), in cisplatin induced
p53 activation and apoptosis
Hastak et al., Proc Natl Acad Sci U S A 2008
:
DNA synthesis from unbalanced nucleotide pools causes limited DNA damage that triggers
ATR-CHK1 dependent
p53 activation
Derheimer et al., Mol Pharmacol 2009
(Ataxia Telangiectasia) :
Psoralen induced DNA interstrand cross-links block transcription and induce
p53 in an
ataxia-telangiectasia and rad3-related dependent manner ... The induction of
p53 phosphorylation by psoralen ICLs did not require factors believed to be involved in the repair of psoralen ICLs [ xeroderma pigmentosum ( XP ) -A, XP-C, XP-F, Cockayne 's syndrome-B, Fanconi anemia ] but did
require the
ataxia-telangiectasia and Rad3 related but not the ataxia-telangiectasia mutated kinase
Bhattacharya et al., Cell Signal 2009
:
The
ATM/ATR kinase inhibitor, CGK733,
blocked CPT induced
p53 Ser15 phosphorylation and protected cells from CPT induced apoptosis
Pedram et al., Mol Biol Cell 2009
:
We find that in estrogen receptor ( ER ) -positive breast cancer cells, UV or ionizing radiation and hydroxyurea rapidly activate
ATR dependent phosphorylation of endogenous
p53 and Chk1
Gáspár et al., FASEB J 2010
:
These TRH effects may be mediated in part by reducing the
ATM/Atr dependent phosphorylation of
p53
Lindsey-Boltz et al., J Biol Chem 2009
:
We find that the
ATR dependent phosphorylation of Chk1, but not
p53 , is strongly stimulated by Claspin
Tibbetts et al., Genes Dev 1999
:
A role for
ATR in the DNA damage
induced phosphorylation of
p53