Lee et al., J Biol Chem 2010
:
Furthermore, in HEK293 cells, TMEM88 attenuated the Wnt/ß-catenin signaling induced by Wnt-1 ligand in a dose dependent manner, and TMEM88 knockdown by RNAi increased Wnt activity ... Together, we propose that TMEM88 associates with Dvl proteins and regulates Wnt signaling in a context dependent manner
Liang et al., Mol Cell Biol 2011
:
In mammalian cells, TMEM198 is required for Wnt signaling and casein kinase 1-induced LRP6 phosphorylation