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HDAC2 — TNFSF10

Text-mined interactions from Literome

Xu et al., Cancer Res 2008 (Breast Neoplasms) : Here, we show that the histone deacetylase (HDAC) inhibitors induce TRAIL in human breast cancer cells
Norian et al., Journal of oncology 2009 : We found that HDAC inhibition in B-CLL cells led to increased TRAIL receptor expression, increased caspase activation, decreased expression of antiapoptotic regulators such as Bcl-2, and ultimately, enhanced TRAIL induced apoptosis
Zhou et al., Leukemia 2013 (Leukemia, Myeloid, Acute) : We here report that inhibition of histone deacetylase (HDAC) using the specific class I HDAC inhibitor SNDX-275 restored the expression of Nur77/Nor1 and induced expression of activator protein 1 transcription factors c-Jun and JunB, and of death receptor TRAIL , in AML cells and in CD34 ( + ) /38 ( - ) AML LSCs. Importantly, SNDX-275 induced extensive apoptosis in AML cells, which could be suppressed by silencing nur77 and nor1