Gene interactions and pathways from curated databases and text-mining

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HOXD13 — RNR1

Text-mined interactions from Literome

Håkansson et al., J Biol Chem 2006 : Therefore, Spd1p inhibits fission yeast RNR activity by interacting with the Cdc22p. Similar to the situation in budding yeast, logarithmically growing fission yeast increases the dNTP pools 2-fold after 3 h of incubation in the UV mimetic 4-nitroquinoline-N-oxide
Moss et al., Genes Dev 2010 : The Ddb1-Cul4 ( Cdt ) ² ubiquitin ligase complex is required for degradation of Spd1 , an inhibitor of RNR in fission yeast ... Our findings support a model in which break induced Rad3 and Ddb1-Cul4 ( Cdt ) ² ubiquitin ligase dependent Spd1 degradation and RNR activation promotes postsynaptic ssDNA gap filling during HR repair