◀ Back to TNF

JUN — TNF

Pathways - manually collected, often from reviews:

• BioCarta mechanism of gene regulation by peroxisome proliferators via ppara: PPAR-alpha/Transcription factors complex (PPARA-JUN_RELA_SP1) → Non-PPRE-Regulated proteins (NOS2A/TNF/MYC/FAT/COX2/NFKBIA) (transcription, inhibits)
  
• KEGG Toll-like receptor signaling pathway: FOS/JUN → TNF (protein-protein, expression)

Text-mined interactions from Literome

Manna et al., Biochem Pharmacol 1999 : Suppression of tumor necrosis factor activated nuclear transcription factor-kappaB, activator protein-1 , c-Jun N-terminal kinase, and apoptosis by beta-lapachone ... Beta-lapachone also abolished TNF induced activation of AP-1 , c-Jun N-terminal kinase, and mitogen activated protein kinase kinase ( MAPKK or MEK )
Ivanov et al., J Biol Chem 1999 (Melanoma) : Forced expression of c-Jun in ATF2 expressing melanoma cells restored TNFalpha expression, suggesting that both forms of ATF2 sequestered transcription factors that positively regulate TNFalpha expression in response to UV irradiation
Feng et al., Infect Immun 1999 : The high-level expression of TNF-alpha persisted over 2 h. Dexamethasone blocked the activation of both NF-kappaB and AP-1 and suppressed the production of TNF-alpha in TEP macrophages stimulated by M. penetrans lipid extract of PK-digested LAMPs
Soto et al., Oncogene 1999 (Neoplasm Invasiveness) : Conversion of HPV 18 positive non-tumorigenic HeLa-fibroblast hybrids to invasive growth involves loss of TNF-alpha mediated repression of viral transcription and modification of the AP-1 transcription complex
Seppänen et al., Oncol Res 1998 (Adenocarcinoma...) : In the present study, we have investigated the effects of interferons-alpha (IFN-alpha) and -gamma ( IFN-gamma ), interleukin-10 (IL-10) and -13 ( IL-13 ), transforming growth factor-beta1 ( TGF-beta1 ), granulocyte-macrophage colony stimulating factor ( GM-CSF ), and tumor necrosis factor-alpha (TNF-alpha) on cell proliferation and induction of transcription factors AP-1 and NF-kappaB in UM-EC-3 human endometrial adenocarcinoma cells and UT-OC-5 ovarian carcinoma cells in vitro
Asschert et al., Int J Cancer 1999 (Ovarian Neoplasms) : TNF-alpha stimulation enhanced AP-1 and induced NF-KB but no NF-IL6 DNA binding in these cells
Manna et al., Oncogene 1999 : Overexpression of gamma-glutamylcysteine synthetase suppresses tumor necrosis factor induced apoptosis and activation of nuclear transcription factor-kappa B and activator protein-1 ... gamma-GCS also abolished the activation of AP-1 induced by TNF and inhibited TNF induced activation of JNK and mitogen activated protein kinase kinase
Brinkman et al., J Biol Chem 1999 : The study presented here shows that autoregulation of TNF-alpha gene transcription by selective signaling through tumor necrosis factor receptor 1 (TNFR1) requires p38 mitogen activated protein ( MAP ) kinase activity and the binding of the transcription factors ATF-2 and Jun to the TNF-alpha cAMP-response element ( CRE ) promoter element
Andoh et al., Clin Exp Immunol 1999 : The EMSAs indicated that sodium butyrate suppressed TNF-alpha induced nuclear factor (NF)-kappaB- and activation protein (AP)-1-DNA binding activity, but enhanced TNF-alpha induced activation of CCAAT/enhancer binding protein ( C/EBP)beta (NF-IL-6 ) -DNA binding activity
Wang et al., Hypertension 1999 (MAP Kinase Signaling System) : Tumor necrosis factor-alpha (TNF-alpha) alone can induce extracellular signal regulated kinase ( ERK ), p38 MAPK, and c-Jun N-terminal kinase activity in a rapid and transient manner, whereas interferon-gamma (IFN-gamma) can induce only ERK
Abe et al., Am J Respir Cell Mol Biol 2000 : In accord with promoter analyses, an electrophoretic mobility shift assay showed that CAM repressed AP-1 binding in TNF-alpha treated BET-1A cells ; however, TNF-alpha induced both AP-1 and NF-kappaB binding activities in BET-1A cells
Gertzberg et al., Am J Respir Cell Mol Biol 2000 : We tested the hypothesis that protein kinase ( PK ) G activation in response to nitric oxide ( ( * ) NO ) mediates tumor necrosis factor (TNF)-alpha induced activation of the transcription factor activating protein-1 (AP-1) in pulmonary microvessel endothelial monolayers ( PEM ) ... TNF treatment ( 1,000 U/ml ) for 4 h induced a significant increase in DNA binding of AP-1
Leonardi et al., J Biol Chem 2000 : TRAF2 is required for TNF induced activation of c-Jun N-terminal kinase/stress activated protein kinase ( JNK/SAPK ), and TRAF2 can also mediate activation of NF-kappaB
Clerk et al., J Mol Cell Cardiol 1999 (MAP Kinase Signaling System) : IL-1 beta and TNF alpha stimulated the phosphorylation of c-Jun and ATF2
Seppänen et al., Eur J Endocrinol 2000 (Cystadenocarcinoma...) : The binding activity of AP-1 was found to be stimulated by the growth inhibitory cytokines, TGF-beta1 and TNF-alpha, and the binding of NF-kappaB was stimulated by TNF-alpha
Manna et al., J Biol Chem 2000 : Protein tyrosine kinase p56lck is required for ceramide induced but not tumor necrosis factor induced activation of NF-kappa B, AP-1 , JNK, and apoptosis ... p56 ( lck ) was also found to be required for ceramide induced but not TNF induced AP-1 activation
Manna et al., J Biol Chem 2000 : AP-1 activation induced by TNF and ceramide was also suppressed by hCG
Manna et al., J Immunol 2000 : p56lck was also found to be required for HIV-tat induced but not TNF induced AP-1 activation
Manna et al., Oncogene 2000 (Lung Neoplasms) : The increase in TNF receptors sensitized H596 cells to TNF induced activation of NF-kappaB, AP-1 and apoptosis ... A549 cells, however, were completely resistant to TNF induced activation of NF-kappaB, AP-1 and apoptosis
Manna et al., J Immunol 2000 : Vesnarinone also blocked NF-kappa B activation induced by several other inflammatory agents, inhibited the TNF induced activation of transcription factor AP-1 , and suppressed the TNF induced activation of c-Jun N-terminal kinase and mitogen activated protein kinase kinase
Vallejo et al., J Immunol 2000 (MAP Kinase Signaling System) : These results indicate that both NF-kappaB and AP-1 ( via p38 MAPK ) are involved in the regulation of TNF-alpha production in GBS stimulated neonatal monocytes
Chainy et al., Oncogene 2000 : Besides NF-kappaB, anethole also suppressed TNF induced activation of the transcription factor AP-1 , c-jun N-terminal kinase and MAPK-kinase
Liu et al., J Neurosci 2000 : However, pretreatment with oATP downregulated activation of NF-kappaB and AP-1 by IL-1beta or TNFalpha
Hirota et al., Biochem Biophys Res Commun 2000 : We demonstrated here that intracellular localization of these redox molecules differ from each other and that the redox molecules differentially regulate NF-kappaB, AP-1 , and CREB activation induced by TNFalpha , PMA, and forskolin and by expression of signaling intermediate kinases, NIK, MEKK, and PKA in HEK293 cells
Manna et al., Cancer Res 2000 : Oleandrin also blocked AP-1 activation induced by TNF and other agents and inhibited the TNF induced activation of c-Jun NH2-terminal kinase
González et al., J Cell Biol 2000 : Our results show that glucocorticoids antagonize the TNF-alpha induced activation of AP-1 by causing the accumulation of inactive JNK without affecting its subcellular distribution
Rahman et al., Biochem Pharmacol 2000 (Lung Diseases) : Regulation of nuclear factor-kappa B, activator protein-1 , and glutathione levels by tumor necrosis factor-alpha and dexamethasone in alveolar epithelial cells ... The promoter regions of the human gamma-GCS subunits contain AP-1 , NF-kappa B, and antioxidant response elements and are regulated by oxidants, growth factors, inflammatory cytokine tumor necrosis factor-alpha (TNF-alpha) , and anti-inflammatory agent ( dexamethasone ) in lung cells ... TNF-alpha also induces the activation of NF-kappa B and AP-1 and the subsequent increase in gamma-GCS heavy subunit transcription in these cells
Manna et al., J Immunol 2000 : Leflunomide also inhibited TNF induced activation of AP-1 and the c-Jun N-terminal protein kinase activation
Tintut et al., Circulation 2000 (Calcinosis...) : Electrophoretic mobility shift assay demonstrated that TNF-alpha enhanced DNA binding of osteoblast specific factor ( Osf2 ), AP1 , and CREB, transcription factors that are important for osteoblastic differentiation
Valladares et al., Endocrinology 2000 : Thus, TNFalpha induced c-Jun messenger RNA expression requires ERKs activation, whereas p38MAPK inhibition enhances its expression ... Finally, although TNFalpha induces c-Jun N-terminal kinase (JNK) activation, transfection of a dominant negative of either JNK1 or JNK2 had no effect on TNFalpha induced apoptosis
Yarosh et al., Photodermatol Photoimmunol Photomed 2000 : Induction of membrane bound TNFalpha was also found in c-fos gene knockout mice deficient in the AP-1 transcription factor, suggesting that, although AP-1 containing c-fos signaling is required for some UV responses, AP-1 containing c-fos is not required for this TNFalpha activation
Shrivastava et al., Antioxid Redox Signal 1999 : In this report, we investigated the effect of various superoxide radical quenchers -- pyrrolidine dithiocarbamate ( PDTC ), N-acetyl-L-cysteine (NAC), and glutathione ( GSH ) -- an hydroxyl radical quencher ( mannitol ), and lipid peroxide quenchers -- butylated hydroxytoluene ( BHT ) and butylated hydroxyanisole ( BHA ) -- on TNF induced activation of nuclear transcription factors-kappa B ( NF-kappa B ) and activator protein-1 (AP-1) , c-jun amino-terminal kinase ( JNK ), and apoptosis in human monocytic U937 cells ... In contrast, none of the radical quenchers had any significant effect on TNF induced AP-1 activation ... Overall, these results suggest that hydroxyl radicals mediate TNF induced apoptosis but not activation of NF-kappa B, AP-1 , and JNK ; superoxide radicals mediate NF-kappa B and JNK activation but potentiate apoptosis ; and lipid peroxides are required for all the signals induced by TNF
Geleziunas et al., Nature 2001 : The interaction of Nef with ASK1 inhibits both Fas- and TNFalpha mediated apoptosis, as well as the activation of the downstream c-Jun amino-terminal kinase
Javelaud et al., Oncogene 2001 (Bone Neoplasms...) : The c-Jun N-terminal kinases (JNK) have been shown to participate in death signaling triggered by certain stimuli and are activated by TNF alpha
Jupp et al., Biochem J 2001 (MAP Kinase Signaling System) : KYM-1 human rhabdomyosarcoma cells and HeLa human cervical epithelial cells, engineered to overexpress TNFR2, displayed c-Jun N-terminal kinase (JNK) activation by wild-type TNF , a TNFR1-specific TNF mutant and a TNFR2-specific mutant TNF in combination with an agonistic TNFR2-specific monoclonal antiserum
Nakamura et al., J Am Soc Nephrol 2001 : The increase in TNF-alpha was attenuated by both a p42/p44 inhibitor, PD098059 ( 10 ( -6 ) M ), and a p38 inhibitor, SB203580 ( 10 ( -6 ) M ), and AP-1 binding activity was inhibited by PD098059
Bischof et al., Early pregnancy (Online) 2001 : Among these we identified two oncogene products ( Jun and Fos ) which were activated by TNF or phorbol esters and which promoted the synthesis of MMP-9
Mukhopadhyay et al., Oncogene 2001 (Prostatic Neoplasms) : TNF induced NF-kappaB activation but not AP-1 activation in LNCaP cells
Li et al., Nature 2002 : TRAF2 is required for TNF-alpha mediated activation of c-Jun N-terminal kinase (JNK) , contributes to activation of NF-kappaB, and mediates anti-apoptotic signals,
Okajima et al., Immunol Rev 2001 (Inflammation) : APC directly inhibits the production of TNF-alpha by inhibiting the activation of both nudear factor kappaB (NFkappaB) and activator protein-1 in monocytes stimulated with LPS
Nicholas et al., J Neuroimmunol 2002 : IGF-2 inhibits TNF alpha induced c-Jun kinase (JNK) activation of the CG4 cell line
Ortiz et al., Am J Physiol Lung Cell Mol Physiol 2002 (Body Weight...) : Enalapril protects mice from pulmonary hypertension by inhibiting TNF mediated activation of NF-kappaB and AP-1
Takeshita et al., J Oral Sci 2002 : The present study suggests a regulatory interference by 1alpha25 ( OH ) 2D3 for RA inhibition of TNF-alpha induced AP-1 activity in osteoblasts
Che et al., Circ Res 2002 : Insulin-like growth factor-1 enhances inflammatory responses in endothelial cells : role of Gab1 and MEKK3 in TNF-alpha induced c-Jun and NF-kappaB activation and adhesion molecule expression ... Because Gab1 is involved in both c-Jun and NF-kappaB activation by TNF-alpha , we focused on Gab1 dependent signaling ... Gab1 associated with MEKK3, and a catalytically inactive form of MEKK3 inhibited TNF-alpha induced c-Jun and NF-kappaB transcriptional activation, suggesting a critical role for Gab1 and MEKK3 in TNF-alpha signaling
Masamune et al., Pancreas 2002 (Acute Disease...) : IL-1 beta and TNF-alpha increased the nuclear factor-kappa B (NF-kappa B)-specific and activator protein-1-specific DNA binding activity, whereas the NF-IL6 activity was not altered
Rahman et al., Mol Cell Biochem 2002 (Inflammation) : Oxidative stress and TNF-alpha induce histone acetylation and NF-kappaB/AP-1 activation in alveolar epithelial cells : potential mechanism in gene transcription in lung inflammation ... H2O2, and TNF-a , and TSA all increased NF-kappaB and AP-1 DNA binding to their consensus sites assessed by the electrophoretic mobility shift assay
Yuksel et al., Thromb Haemost 2002 (MAP Kinase Signaling System...) : Activated protein C inhibits lipopolysaccharide induced tumor necrosis factor-alpha production by inhibiting activation of both nuclear factor-kappa B and activator protein-1 in human monocytes ... These observations strongly suggest that APC inhibited LPS induced TNF-alpha production by inhibiting the activation of both NF-kappa B and AP-1 and that the inhibitory activity of APC might depend on its serine protease activity
Saeki et al., Biochem J 2002 (MAP Kinase Signaling System) : EGCG as well as VP16 and TNF induced activation of two apoptosis regulating mitogen activated protein ( MAP ) kinases, namely c-Jun N-terminal kinase (JNK) and p38 MAP kinase, in both human leukaemic U937 and OCI-AML1a cells
Flora et al., Neuromolecular Med 2002 (Inflammation) : Methamphetamine induced TNF-alpha gene expression and activation of AP-1 in discrete regions of mouse brain : potential role of reactive oxygen intermediates and lipid peroxidation
Varela-Rey et al., FEBS Lett 2002 : TNF-alpha increased extracellular regulated kinase and Jun-N-terminal kinase phosphorylation, but these effects were not related to its inhibitory effect on alpha1 ( I ) procollagen ( col1a1 ) mRNA levels
Borgmann et al., Endothelium : journal of endothelial cell research 2002 : Alteration of cytokine release was accompanied by reduced basal and TNF-alpha stimulated nuclear factor-kappa B (NF-kappa B) and activator protein-1 (AP-1) activity
Jiang et al., J Biol Chem 2003 (Insulin Resistance) : On the other hand, both PMA and TNFalpha activated the c-Jun N-terminal kinase (JNK) , which has been reported to directly phosphorylate IRS1 Ser-307
Tang et al., Mol Cell Biol 2002 (MAP Kinase Signaling System) : The absence of NF-kappaB mediated inhibition of c-Jun N-terminal kinase activation contributes to tumor necrosis factor alpha induced apoptosis
Littlejohn et al., Biochem Pharmacol 2003 : Modulation by caspases of tumor necrosis factor stimulated c-Jun N-terminal kinase activation but not nuclear factor-kappaB signaling ... TNF can stimulate the proinflammatory transcription factor nuclear factor-kappaB (NF-kappaB) as well as the stress induced kinase c-Jun N-terminal kinase (JNK) through mechanisms that are not fully delineated
Higuchi et al., Antioxid Redox Signal 2002 (Leukemia, Myeloid, Acute) : Additionally, tumor necrosis factor (TNF) induced activation of NF-kappaB and AP-1 observed in ML-1a was greatly reduced in clone 19
Chen et al., Kidney Int 2003 : In contrast, curcumin, an activating protein (AP)-1 inhibitor, attenuated TNF-alpha stimulated phospho-c-Jun levels and fractalkine expression without discernible effects on TNF-alpha induced degradation of I-kappaBalpha or NF-kappaB nuclear translocation ... The present data indicate that TNF-alpha activation of PKCzeta/iota, p42/44 MAPK, c-Jun/AP-1 , and p65/NF-kappaB are involved in TNF-alpha stimulated MC fractalkine expression, with the soluble fractalkine mediating in part the TNF-alpha induced monocyte transmigration in vitro
Chen et al., Br J Pharmacol 2003 : ( 5 ) Pretreatment with pentoxifylline ( 0.1-1 mg ml(-1) ) decreased TNF-alpha stimulated fractalkine mRNA and protein expression, which was preceded by a reduction in TNF-alpha activated phosphorylation of PKC, p42/44 MAPK and c-Jun as well as degradation of I-kappaBalpha and p65/NF-kappaB nuclear translocation
Yuksel et al., J Pharmacol Exp Ther 2003 : Gabexate mesilate, a synthetic protease inhibitor, inhibits lipopolysaccharide induced tumor necrosis factor-alpha production by inhibiting activation of both nuclear factor-kappaB and activator protein-1 in human monocytes ... These observations strongly suggest that gabexate mesilate inhibited LPS induced TNF-alpha production in human monocytes by inhibiting activation of both NF-kappaB and AP-1
Ventura et al., Mol Cell Biol 2003 (MAP Kinase Signaling System) : c-Jun NH ( 2 ) -terminal kinase is essential for the regulation of AP-1 by tumor necrosis factor ... We show that JNK is required for the normal regulation of AP-1 by TNF
Frost et al., Endocrinology 2003 : TNF alpha stimulated the phosphorylation of c-Jun and specific inhibition of the Jun N-terminal kinase pathway, but not other MAPK pathways, completely prevented the TNF alpha induced drop in IGF-I mRNA
Harper et al., J Biol Chem 2003 : TRADD also binds two other adaptors receptor interacting protein ( RIP ) and TNF-receptor associated factor 2 (TRAF2), which are required for TNF induced NF-kappaB and c-Jun N-terminal kinase activation, respectively
Lee et al., Br J Pharmacol 2003 : The effects of sauchinone on the inducible nitric oxide synthase (iNOS), tumor necrosis factor-alpha (TNF-alpha) and cyclooxygenase 2 (COX-2) gene expression and on the activation of transcription factors, nuclear factor-kappaB (NF-kappaB), CCAAT/enhancer binding protein (C/EBP), activator protein-1 (AP-1) and cAMP-response element binding protein ( CREB ) were determined in Raw264.7 cells as part of the studies on its anti-inflammatory effects
Funakoshi-Tago et al., J Biol Chem 2003 : Similarly, TNF induced activation of activator protein 1 or NF-IL-6 was not impaired in FAK-/- cells
Takada et al., Mol Cell Biol 2003 : TNF induced activation of NF-kappaB is accelerated in SODD-deficient cells, but TNF induced c-Jun N-terminal kinase activity is slightly repressed
Baillie et al., J Virol 2003 (Cytomegalovirus Infections) : The reduction appeared to be due to relocalization of TNFRI from the cell surface and was reflected in the elimination of TNF-alpha induced Jun kinase activity
Kähäri et al., J Biol Chem 1992 : These observations suggest that the inhibitory effects of TNF-alpha on elastin gene expression involve the transcription factor AP-1
Chiu et al., Chin J Physiol 2002 : Moreover, in ECs either presheared or remained in a static condition prior to stimulation by TNF-alpha while under shear flow, the ability of TNF-alpha to induce AP-1-DNA binding activity in the nucleus was reduced
Lagoumintzis et al., Infect Immun 2003 : Activation of NF-kappa B and AP-1 by P. aeruginosa GLP may be involved not only in TNF-alpha induction but also in many of the inflammatory responses triggered in the course of infection with P. aeruginosa
Sakon et al., EMBO J 2003 : NF-kappaB downregulates tumor necrosis factor (TNF) induced c-Jun N-terminal kinase (JNK) activation that promotes cell death, but the mechanism is not yet fully understood
Chen et al., Arterioscler Thromb Vasc Biol 2003 (Arteriosclerosis) : Electrophoretic mobility shift assay demonstrated that both GBE and probucol inhibited transcription factor nuclear factor-kappaB activation in TNF-alpha stimulated HAECs ( 55.2 % and 65.6 % inhibitions, respectively ) but only GBE could inhibit the TNF-alpha stimulated activator protein 1 activation ( 45.1 % inhibition, P < 0.05 )
Li et al., Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2003 : To study the effect of nuclear transcription factor AP-1 on tumor necrosis factor alpha (TNF-alpha) or minimal modified low density lipoprotein ( mmLDL ) -induced expression of plasminogen activator inhibitor-1 ( PAI-1 ) in human vascular endothelial cells
Lerner-Marmarosh et al., Arterioscler Thromb Vasc Biol 2003 (Inflammation) : Human umbilical vein endothelial cells preexposed to flow showed decreased tumor necrosis factor (TNF)-alpha induced c-Jun and NF-kappaB transcriptional activation ... Because MEKK3 and Gab1 are critical for TNF-alpha induced c-Jun and NF-kappaB activation, we determined the role of SHP-2 phosphatase activity in MEKK3 signaling
Yasumoto et al., J Biol Chem 1992 (Stomach Neoplasms) : Moreover, gel retardation analyses revealed that TNF alpha and IFN gamma synergistically induced the binding of NF-kB like as well as AP-1 like proteins bound to these sites
Yang et al., J Biol Chem 2003 (Carcinoma, Hepatocellular) : Tumor necrosis factor alpha (TNFalpha) , which activates both NF-kappa B and AP-1 , increased MAT2A expression in a dose- and time dependent manner, binding of both NF-kappa B and AP-1 to the MAT2A promoter and MAT2A promoter activity, with the latter effect blocked by site directed mutagenesis of the NF-kappa B and AP-1 binding sites
Jeong et al., J Biol Chem 2004 : The TNF-alpha induced activation of c-Jun N-terminal kinase (JNK) and p38 mitogen activated protein kinases ( MAPKs ), however, was promoted by depletion of TRP14 but not by that of Trx1
Son et al., Endocrinology 2004 (MAP Kinase Signaling System) : In vitro TNF did not increase c-Jun and proliferation in granulosa cells from TNFR1 knockout mice ... The time course of TNF induced c-Jun revealed biphasic patterns of short-term ( 3 h ) and long-term ( 24 h ) induction ... In conclusion, the above results demonstrate that TNF increased c-Jun by activating stress activated protein kinase/c-Jun-NH ( 2 ) -teminal kinase signaling via TNFR1 in mouse granulosa cells, and the induced c-Jun resulted in increased cell proliferation
Arnott et al., Oncogene 2004 (Skin Neoplasms) : Keratinocyte derived TNF-alpha acts as an endogenous tumour promoter and can also regulate AP-1 activity in mouse epidermis
Giri et al., Apoptosis 1999 : In this report, we investigated the effect of TNF on activation of NF-kappa B, c-Jun N-terminal kinase (JNK) , and apoptosis in vincristine-resistant human histiocytic lymphoma U937-VR cells
Takada et al., J Biol Chem 2004 : PTD-p65-P1 had no effect on TNF induced AP-1 activation
Yoshizumi et al., Exp Cell Res 2004 : Ebselen inhibits tumor necrosis factor-alpha induced c-Jun N-terminal kinase activation and adhesion molecule expression in endothelial cells ... Extracellular signal regulated kinase ( ERK1/2 ), c-Jun N-terminal kinase (JNK) and p38 were rapidly and significantly activated by TNF-alpha in HUVEC ... Finally, TNF-alpha induced activator protein-1 (AP-1) and nuclear factor-kappaB (NF-kappaB) activation and resultant intracellular adhesion molecule-1 ( ICAM-1 ) and vascular cell adhesion molecule-1 ( VCAM-1 ) expressions were inhibited by ebselen
Park et al., Nephrol Dial Transplant 2004 : We investigated the role of NF-kappa B and AP-1 in tumour necrosis factor alpha (TNF-alpha) induced monocyte chemoattractant protein 1 ( MCP-1 ) production in cultured human glomerular endothelial cells ( HGEC ) ... ( i ) TNF-alpha increased NF-kappa B and AP-1 binding activity
Moon et al., J Cell Physiol 2004 : Furthermore, the transactivation of TNF-alpha stimulated NF-kappaB and AP-1 was inhibited by U0126 treatment ... Overexpression of RasN17 also abolished the TNF-alpha stimulated NF-kappaB and AP-1 activity
Chen et al., J Pharmacol Exp Ther 2004 : PD98059 abolished TNF-alpha activated p42/44 MAPK phosphorylation and c-Fos up-regulation, whereas SP600125 inhibited TNF-alpha activated JNK and c-Jun phosphorylation
Rao et al., J Biol Chem 2004 (Breast Neoplasms...) : hCG treatment prevented the tumor necrosis factor dependent NF-kappaB and AP-1 activation, which paralleled a decrease in the phosphorylation and degradation of IkappaBalpha
Okajima et al., Clin Chem Lab Med 2004 (Inflammation) : APC inhibited ET-induced TNF-alpha production in human monocytes by inhibiting activation of nuclear factor K-B and activator protein-1 in vitro
Ait-Ali et al., Mol Endocrinol 2004 : In addition, TNF-alpha increased the binding activity of activator protein-1 (AP-1) and stimulated transcription of a reporter gene containing AP-1-responsive elements in chromaffin cells
Granet et al., Cytokine 2004 : IL-1 and TNF-alpha induced egr-1 and all AP-1 member expression, except fosB and junD
Faggioli et al., Biochim Biophys Acta 2004 : In combination with p65 and/or C/EBPdelta, TAM-67 also synergistically activated the IL-6 promoter, while it inhibited TNF-alpha induced AP-1 activity directing an AP-1-responsive reporter plasmid
Reiterer et al., J Nutr 2004 (Inflammation) : However, if zinc was added back, all PPAR agonists significantly downregulated the TNF-alpha mediated induction of inflammatory transcription factors NF-kappaB and AP-1 and significantly reduced the expression of their target genes, VCAM-1 and IL-6
Cho et al., Int Immunopharmacol 2004 : In view of the potential role of AP-1 in the induction of TNF-alpha , we next examined the inhibitory effects of arctigenin on the expression of TNF-alpha
Okajima et al., Curr Vasc Pharmacol 2004 (Hypotension...) : APC inhibits ET-induced TNF-alpha production in vitro in human monocytes by inhibiting activation of NFkappaB and AP-1 by inhibiting degradation of IkappaB and mitogen activated protein kinase pathways, respectively
Shi et al., Oncogene 2004 (Colonic Neoplasms...) : In addition, inhibition of NF-kappaB by luteolin led to augmentation and prolongation of c-Jun N-terminal kinase (JNK) activation induced by TNFalpha
Kim et al., Int Immunopharmacol 2004 : PA and TNF-alpha increased the phosphorylation of extracellular signal regulated kinase ( ERK ) -1/2, p38-kinase, and c-Jun N-terminal kinase (JNK) by Western blotting
Yamauchi et al., Fertil Steril 2004 (Endometriosis) : Electrophoretic mobility shift assay revealed that U0126 attenuated activator protein-1 (AP-1) activation induced by TNF-alpha
Aneja et al., Crit Care Med 2004 : Theaflavin also significantly reduced tumor necrosis factor-alpha mediated DNA binding of activator protein-1
Murata-Ohsawa et al., Int J Mol Med 2004 : The TNF-alpha induced activation of c-Jun N-terminal kinase (JNK) , p38, and NF-kappaB was not affected by Delta-1 stimulation
Gauss et al., J Leukoc Biol 2005 : As p67phox can be up-regulated by tumor necrosis factor alpha (TNF-alpha) , which activates AP-1 , we hypothesized that TNF-alpha might regulate NCF2transcription via AP-1
Liu et al., Mol Cell Biol 2004 : c-Jun N-terminal protein kinase 1 (JNK1) , but not JNK2, is essential for tumor necrosis factor alpha induced c-Jun kinase activation and apoptosis ... Here we report that JNK1, but not JNK2, is essential for tumor necrosis factor alpha (TNF-alpha) induced c-Jun kinase activation, c-Jun expression, and apoptosis
Fichorova et al., Antimicrob Agents Chemother 2005 (Vaginitis) : Within 6 h of exposure, TNF-alpha and N-9 triggered NF-kappaB and AP-1/cFos activation and upregulated interleukins and an array of chemokines by vaginal and polarized cervical epithelial cells
Biswas et al., Antioxid Redox Signal 2005 : Curcumin inhibited both H2O2- and TNF-alpha mediated activation of NF-kappaB and AP-1 , and IL-8 release
Jana et al., Free Radic Biol Med 2005 : All three cytokines alone induced the activation of AP-1 while IL-1beta and TNF-alpha but not IFN-gamma induced the activation of NF-kappaB
Siebert et al., Arthritis Rheum 2005 : TNFalpha induced activation of NF-kappaB and AP-1 was decreased in the primary dermal fibroblasts with the C43S TNFRSF1A mutation
Takeshita et al., J Oral Sci 2005 (Second Messenger Systems) : Sphingosine 1-phosphate acts as a signal molecule in ceramide signal transduction of TNF-alpha induced activator protein-1 in osteoblastic cell line MC3T3-E1 cells ... The present study thus suggests that SPP acts as a signal molecule in ceramide dependent signal transduction in TNF-alpha induced AP-1 in osteoblastic MC3T3-E1 cells ... We previously demonstrated that tumor necrosis factor (TNF)-alpha stimulated the production of activation protein (AP)-1 , a transcriptional factor, in mouse osteoblastic MC3T3-E1 cells
Nakamura et al., Med Hypotheses 2005 (Arteriosclerosis...) : In the process of the search for such a unique anti-hypertensive drug, we have recently found that azelnidipine, a newly developed and commercially used long acting dihydropyridine based calcium antagonist ( DHP ), inhibited TNF-alpha induced activator protein-1 activation and interleukin-8 expression in human umbilical vein endothelial cells by suppressing NADPH oxidase mediated reactive oxygen species generation
Luedemann et al., Alcohol Clin Exp Res 2005 (Alcoholism...) : DNA binding assays revealed that ethanol induced TNF up regulation was AP1 dependent
Yang et al., Biochem J 2005 : TNFalpha induces NF-kappaB ( nuclear factor kappaB ) and AP-1 ( activator protein 1 ) nuclear binding activities ... Blocking NF-kappaB also lowered basal c-Jun expression and blunted the TNFalpha mediated increase in c-Jun mRNA levels
Masamune et al., Biochem Pharmacol 2005 : Ellagic acid inhibited IL-1beta- and TNF-alpha induced activation of activator protein-1 and mitogen activated protein kinases ( extracellular signal regulated kinase, c-Jun N-terminal kinase and p38 mitogen activated protein kinase ), but not of nuclear factor-kappaB
Yamada et al., J Urol 2005 (Urinary Bladder Neoplasms) : TNF-alpha also activated NF-kappaB, AP-1 and ERK1/2
Lee et al., Biochem Biophys Res Commun 2005 (Fibrosarcoma) : We also found that SM-7368 strongly inhibits TNF-alpha induced NF-kappaB activity but not AP-1 activity
Masamune et al., J Cell Biochem 2006 : Curcumin inhibited interleukin-1beta- and TNF-alpha induced activation of activator protein-1 (AP-1) and mitogen activated protein ( MAP ) kinases ( ERK, c-Jun N-terminal kinase (JNK), and p38 MAP kinase ), but not of nuclear factor-kappaB (NF-kappaB) ... Curcumin inhibited interleukin-1beta- and TNF-alpha induced activation of activator protein-1 (AP-1) and mitogen activated protein ( MAP ) kinases ( ERK, c-Jun N-terminal kinase (JNK) , and p38 MAP kinase ), but not of nuclear factor-kappaB (NF-kappaB)
Bryce et al., Int Immunol 2006 (Hypersensitivity...) : We have previously reported that tumor necrosis factor receptor associated factor 1 ( TRAF1 ), an intracellular protein, which binds to a range of molecules, including tumor necrosis factor (TNF) receptor family members, regulates TNF induced NF-kappaB and AP-1 signaling as well as TCR triggered proliferative responses in T cells
Shun et al., Ann Otol Rhinol Laryngol 2005 (Nasal Polyps) : The electrophoretic mobility shift assay revealed that TNF-alpha triggered AP-1 and DNA binding and again, NS-398 and meloxicam inhibited this reaction via reducing c-Fos synthesis
Granja et al., J Immunol 2006 : Furthermore, we present evidence that A238L inhibits the activation of TNF-alpha by modulating NF-kappaB, NF-AT, and c-Jun trans activation through a mechanism that involves CREB binding protein/p300 function, because overexpression of these transcriptional coactivators recovers TNF-alpha promoter activity
Lendemans et al., J Endotoxin Res 2006 : In contrast, the broad-spectrum tyrosine kinase inhibitor genistein and the MEK-1 inhibitor ( PD98059 ) abrogated GM-CSF priming of TNF-alpha release and activation of both NF-kappaB and AP-1
Wang et al., Cancer Res 2006 (Lung Neoplasms) : The other components of the TNF receptor I signaling cascade were not altered, whereas TNF induced c-Jun NH ( 2 ) -terminal kinase activation and apoptosis were potentiated
Cha et al., J Pharmacol Exp Ther 2006 : Western blot analysis demonstrated that Syk inhibition by R406 markedly suppressed TNFalpha induced c-Jun N-terminal kinase (JNK) phosphorylation in FLS, with a modest decrease in extracellular signal regulated kinase phosphorylation
Asano et al., J Pharm Pharmacol 2006 : Addition of meloxicam into synovial fibroblast cultures inhibited dose-dependently mRNA expression for MMPs and TIMPs, which were increased by TNF-alpha stimulation, through the suppression of NF-kappaB and AP-1 activation
Choi et al., Mol Cell Biol 2006 (Carcinoma, Hepatocellular...) : We recently reported that NS5A protein interacts with TRAF2 and modulates tumor necrosis factor alpha (TNF-alpha) induced NF-kappaB and Jun N-terminal protein kinase (JNK)
Guillermet-Guibert et al., Cell Death Differ 2007 : Tumor necrosis factor alpha (TNFalpha) stimulated both NF-kappaB and c-Jun NH2-terminal kinase (JNK) activities, which had opposite action on cell survival
Chen et al., Shock 2006 (Burns...) : Thermal injury also induces TNF-alpha dependent delay apoptosis and TNF-alpha independent AP-1 activation of neutrophil at 3 h after thermal injury
Graham et al., J Biol Chem 2006 : Analysis of differentiating epithelia showed that only well differentiated enterocytes activated the 4-kb long MLCK promoter in response to TNF, and consensus promoter reporters demonstrated that TNF induced NFkappaB activation decreased during differentiation while TNF induced AP-1 activation increased
Stewart et al., J Interferon Cytokine Res 2006 : Here, we report that activation of c-Jun N-terminal kinase (JNK) during dsRNA treatment or respiratory syncytial viral ( RSV ) infection negatively regulates the induction of TNF-alpha in human epithelial cells
Afonso et al., Free Radic Biol Med 2006 : In agreement with these findings, EMSA shows a TNF-alpha induced increase in AP-1 and a decrease in Sp1 DNA binding
Takada et al., Oncogene 2007 : Among the MAPKs, it was interesting that whereas TNF induced c-Jun N-terminal kinase (JNK) activation was abolished, activation of p44/p42 MAPK and p38 MAPK was potentiated in PKR deleted cells
Wullaert et al., Biochem Pharmacol 2006 : However, during the past few years it has become clear that NF-kappaB mediated inhibition of cell death also involves attenuating TNF induced activation of c-Jun activating kinase (JNK)
Lee et al., Life Sci 2006 : Emodin was determined to inhibit TNF alpha induced activation of AP-1 promoter, an important nuclear transcription factor in MMP-1 expression
Gan et al., J Cell Biol 2006 (Fetal Death) : Consistent with this, FIP200 KO mouse embryo fibroblasts and liver cells showed increased apoptosis and reduced c-Jun N-terminal kinase phosphorylation in response to tumor necrosis factor (TNF) alpha stimulation, which might be mediated by FIP200 interaction with apoptosis signal regulating kinase 1 ( ASK1 ) and TNF receptor associated factor 2 (TRAF2), regulation of TRAF2-ASK1 interaction, and ASK1 phosphorylation
Skayian et al., Life Sci 2006 : It was concluded that TNF-alpha activates NF-kappaB and AP-1 and induces PGE ( 2 ) release which alters dose-dependently the activity of the pump by activating different EP receptors with different affinities for PGE ( 2 )
Adiseshaiah et al., J Immunol 2006 (MAP Kinase Signaling System) : A JNK independent signaling pathway regulates TNF alpha stimulated , c-Jun-driven FRA-1 protooncogene transcription in pulmonary epithelial cells ... Although TNF-alpha stimulates phosphorylation of c-Jun , the inhibition of JNK activity had no significant effect on FRA-1 induction
Nakajima et al., EMBO J 2006 : Inhibition of NF-kappaB activation increases susceptibility to tumor necrosis factor (TNF)alpha induced cell death, concurrent with caspases and prolonged c-Jun N-terminal kinase (JNK) activation, and reactive oxygen species ( ROS ) accumulation
Oyama et al., J Periodontal Res 2007 : Roxithromycin significantly inhibited TNF-alpha induced c-Jun N-terminal kinase activation ( JNP ) and marginally inhibited extracellular signal regulated kinase ( ERK ) 1/2 activation, but not p38 mitogen activated protein kinase activation
Bouzakri et al., J Biol Chem 2007 (Insulin Resistance) : We tested whether mitogenic activated protein kinase kinase kinase kinase isoform 4 ( MAP4K4 ) causes the TNF-alpha induced negative regulation of extracellular signal regulated kinase-1/2 ( ERK-1/2 ), c-Jun NH2-terminal kinase (JNK) , and the insulin receptor substrate-1 (IRS-1) on the insulin signaling pathway governing glucose metabolism
Jara et al., J Neurochem 2007 : Combined TNFalpha and NMDA stimulation results in a transient increase in activity of extracellular signal regulated kinases ( ERKs ) and c-Jun N-terminal kinases (JNKs)
Chung et al., Lab Invest 2007 : 1,25 ( OH ) ( 2 ) D ( 3 ) inhibited TNF induced phosphorylation of c-Jun without affecting phosphorylation of the other pathways
Schlaepfer et al., J Biol Chem 2007 : FAK was not required for TNFalpha mediated nuclear factor-kappaB or c-Jun N-terminal kinase activation
Tsou et al., Toxicol Appl Pharmacol 2007 : We also demonstrated that intracellular glutathione does not modulate the activation of MAPKs and/or their downstream AP-1 induced by lower TNF-alpha ... Although AP-1 activation by the lower TNF-alpha was not detected in our systems, we could not rule out the possible involvement of transiently activated MAPKs/AP-1 in the regulation of TNF-alpha induced adhesion molecule expression
Roumestan et al., Respir Res 2007 (Asthma...) : In lung epithelial cells, these compounds decreased TNF-alpha induced RANTES expression as well as the activity of nuclear factor-kappaB and activator protein-1
Sandur et al., Free Radic Biol Med 2007 : The suppression of TNF induced AP-1 activation by curcumin was also reversed by glutathione
Berndt et al., Mol Cell Biochem 2008 : Here we show ( i ) that fluorescently labeled MIF is internalized by NIH 3T3 cells within minutes, ( ii ) compromises the induction of phospho-c-Jun levels by TNFalpha and PMA and, hence, is biologically active, but ( iii ) is not able to interfere with co-activation by Jab1/CSN5 of the androgen receptor
Kawauchi et al., Biol Pharm Bull 2007 : cPrG.HCl potently suppressed AP-1 activity induced by tumor necrosis factor (TNF) alpha and phorbol myristate acetate ( PMA )
Moussaieff et al., Mol Pharmacol 2007 : The inhibitory effect seems specific ; IA did not interfere with TNFalpha induced activation of c-Jun N-terminal kinase (JNK) and p38 mitogen activated protein kinase
Srivastava et al., J Biol Chem 2007 : Furthermore, overexpression of a dominant negative mutant of TAK1 blocked the TNF-alpha induced expression of MMP-9 and activation of NF-kappaB and AP-1
Kanda et al., Am J Physiol Cell Physiol 2007 : Histamine alone enhanced transcriptional activities of NF-kappaB and activator protein-1 (AP-1) and potentiated TNF-alpha induced NF-kappaB and AP-1 activities or IFN-gamma induced NF-kappaB and STAT1 activities ... These results suggest that histamine stimulates H1 receptor and potentiates TNF-alpha- or IFN-gamma induced hBD-2 production dependent on NF-kappaB, AP-1 , or STAT1 in human keratinocytes
Xu et al., Endocrinology 2008 (Acute Disease...) : Exogenous TNF-alpha infusion increased c-Jun N-terminal kinase phosphorylation and insulin receptor substrate-1 serine 307 phosphorylation, and inhibited insulin induced signaling in liver
Grounds et al., Clin Exp Pharmacol Physiol 2008 (Necrosis) : 3. Activation of TNF signalling via the c-Jun N-terminal kinase (JNK) can inhibit IGF-1 signalling by phosphorylation and conformational changes in insulin receptor substrate (IRS)-1 downstream of the IGF-1 receptor
Nishida et al., Am J Physiol Gastrointest Liver Physiol 2008 : Furthermore, LY294002 suppressed both IL-1beta- and TNF-alpha induced NF-kappaB activation and IL-1beta-, TNF-alpha-, and IFN-gamma induced activated protein-1 (AP-1) activation
Palin et al., Psychopharmacologia 2008 (Body Weight) : TNFalpha binding induces receptor trimerization, activation of c-Jun N-terminal kinase (JNK) , and induction of downstream transcription factors
Takada et al., Mol Pharmacol 2008 (Neoplasms) : Flavopiridol suppresses tumor necrosis factor induced activation of activator protein-1 , c-Jun N-terminal kinase, p38 mitogen activated protein kinase ( MAPK ), p44/p42 MAPK, and Akt, inhibits expression of antiapoptotic gene products, and enhances apoptosis through cytochrome c release and caspase activation in human myeloid cells ... TNF is a potent inducer of activator protein-1 (AP-1) , and flavopiridol abrogated this activation in a dose- and time dependent manner
Li et al., Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 2008 : To study the role of activator protein-1 (AP-1) in the up-regulation expression of tumor necrosis factor-alpha (TNF-alpha) and transforming growth factor-beta1 ( TGF-beta(1) ) in silica stimulated macrophage cells ( RAW264.7 )
Herbein et al., Curr HIV Res 2008 : Since tumor necrosis factor alpha (TNFalpha) activates NF-kappaB and AP-1 , we investigated the role of exogenous Nef protein in TNFalpha stimulated U937 cells and primary macrophages ... We observed that exogenous Nef and TNFalpha synergistically activate NF-kappaB and AP-1 in U937 cells and primary macrophages resulting in enhanced stimulation of the HIV-1 long terminal repeat ( LTR ), and subsequently in enhanced viral replication in both chronically infected promonocytic U1 cells and acutely HIV-1 infected primary macrophages
Lee et al., Oncol Rep 2008 (MAP Kinase Signaling System...) : The transactivation of TNF-alpha stimulated NF-kappaB, AP-1 and Sp-1 were inhibited by U0126 and SB203580 treatment
Brechter et al., Bone 2008 : EMSA showed that IL-1beta and TNF-alpha activated NF-kappaB and AP-1 in MG-63 cells
Bianchi et al., Neurobiol Aging 2010 (Encephalitis...) : We show here that : ( 1 ) S100B also stimulates AP-1 transcriptional activity in microglia via RAGE dependent activation of JNK ; ( 2 ) S100B upregulates IL-1beta and TNF-alpha expression in microglia via RAGE engagement ; and ( 3 ) S100B/RAGE induced upregulation of COX-2, IL-1beta and TNF-alpha expression requires the concurrent activation of NF-kappaB and AP-1
Mukhopadhyay et al., Toxicol Lett 2008 (MAP Kinase Signaling System) : TNF-alpha induces activating protein 1 (AP-1) activation via phosphorylation of mitogen activated protein kinases ( MAPKs )
Seppänen et al., Acta Obstet Gynecol Scand 2008 (Carcinoma, Endometrioid...) : We were able to show that IFN-gamma, TGF-beta(1) and TNF-alpha all increased the binding activity of transcription factor AP-1 ( AP-1 )
Suh et al., Vascul Pharmacol 2009 (MAP Kinase Signaling System) : Furthermore, Western blot analysis indicated that the TNF-alpha induced phosphorylation of extracellular signal regulated kinase 1 and 2 ( ERK1/2 ), p38 and c-Jun N-terminal kinase (JNK) were strongly inhibited by DPT
Kim et al., Biochem Pharmacol 2009 : The activation of activator protein-1 by TNF-alpha was inhibited by myricetin in a dose dependent manner
Kim et al., Molecules (Basel, Switzerland) 2008 (Breast Neoplasms) : Therefore, we further examined the effects of BBR on TNF-alpha induced AP-1 DNA binding activity which is a downstream target of ERK and p38 ... Our data showed that TNF-alpha induced AP-1 DNA binding activity was inhibited by BBR
Yogesha et al., J Immunol 2009 (Arthritis, Experimental...) : We found that IL-3 prevented TNF-alpha induced c-fos nuclear translocation and AP-1 DNA binding activity
Wang et al., Int Immunopharmacol 2009 (Disease Models, Animal...) : 3 h after resuscitation, pulmonary capillary leakage and wet/dry weight ratio, levels of tumor necrosis factor (TNF)-alpha , interleukin (IL)-6, malondialdehyde ( MDA ), oxidized and reduced glutathione ( GSH and GSSG ), myeloperoxidase (MPO) activity, nuclear factor (NF)-kappaB, activator protein (AP)-1 activation , and lung microscopic and ultrastructural histological changes were measured
Li et al., Inhal Toxicol 2009 : Exposure to cigarette smoke upregulates AP-1 activity and induces TNF-alpha overexpression in mouse lungs
Wang et al., Inflammation 2009 (Inflammation...) : Three hour after resuscitation, bacterial translocation ( BT ), intestinal permeability, ileal levels of tumor necrosis factor (TNF)-alpha , interleukin (IL)-6, malondialdehyde ( MDA ), oxidized and reduced glutathione ( GSH and GSSG ), myeloperoxidase (MPO) activity, nuclear factor (NF)-kappaB, activator protein (AP)-1 activation , and ileal microscopic and ultrastructural histological changes were measured
Dai et al., J Cell Mol Med 2010 : We report here that HSP70 over-expression in human colon cancer cells can inhibit TNFalpha induced NFkappaB activation but promote TNFalpha induced activation of c-Jun N-terminal kinase (JNK) through interaction with TNF receptor (TNFR) associated factor 2 ( TRAF2 )
O'Hara et al., Cytokine 2009 : Silencing of Ref-1 in AGS cells inhibited basal and TNF-alpha induced AP-1 and NF-kappaB DNA binding activity, but not their nuclear accumulation
Shyu et al., J Biomed Sci 2009 : The gel shift and promoter activity assay showed that TNF-alpha increased AP-1 binding activity and resistin promoter activity, while SP600125 and atorvastatin inhibited the AP-1 binding activity and resistin promoter activity induced by TNF-alpha
Yin et al., Biomed Pharmacother 2009 (Breast Neoplasms) : Using luciferase reporter assays, we demonstrated that TNF-alpha significantly increased activator protein-1 (AP-1) transcriptional activity in the MCF7 cells
Folco et al., J Biol Chem 2009 (Inflammation...) : We demonstrate that pretreatment of these cells with adiponectin inhibits phosphorylation of nuclear factor kappaB inhibitor ( IkappaB ), c-Jun N-terminal kinase (JNK) , and p38 mitogen activated protein kinase ( MAPK ), induced by either lipopolysaccharide (LPS) or tumor necrosis factor (TNF) alpha, as well as STAT3 phosphorylation induced by interleukin-6 (IL6)
Nijboer et al., Stroke 2009 (Cerebral Infarction...) : When NF-kappaB was inhibited after neonatal cerebral HI, JNK/AP-1 activity was increased and required for increased TNF-alpha expression
Wang et al., Cytokine 2009 (Acute Lung Injury) : ZD 7155 also reduced the mRNA expression of TNF-alpha and IL-1 beta, inhibited the activation of NF-kappaB and AP-1 , and improved lung histopathology
Cui et al., Biochem Biophys Res Commun 2009 (Glomerulonephritis, IGA...) : Adenoviral knockdown of CYLD did not affect albumin-, hydrogen peroxide ( H ( 2 ) O ( 2 ) ) -, tunicamycin- or thapsigargin induced cell death ; however, it enhanced TNFalpha induced expression of intracellular adhesion molecule (ICAM)-1 as well as activation of c-Jun N-terminal kinase (JNK)
Bae et al., Inflammation 2010 (Acute Lung Injury...) : In the present study, production of TNF-alpha and MIP-2 and activation of extracellular signal regulated kinases ( ERK ) 1/2, c-Jun amino terminal kinases (JNK) and p38 in RAW264.7 cells were measured
Arancibia et al., J Cell Mol Med 2011 : Cells expressing a PI3K mutant ( p85-dominant negative, DN ; p85 d478-511 ) and exposed to Pam ( 3 ) -Cys-Ser-Lys ( 4 ) in the presence or absence of dexamethasone, showed enhanced tumour necrosis factor ( TNF ) a expression while AP-1 and NF-?B transcriptional activity were repressed
Mascia et al., J Invest Dermatol 2010 (Dermatitis, Atopic...) : Furthermore, EGFR activation enhanced TNF-alpha induced c-Jun phosphorylation and DNA binding, whereas c-Jun silencing reduced GM-CSF expression
Sondarva et al., Cell Res 2010 : Mixed lineage kinase 3 (MLK3) is a mitogen activated protein kinase kinase kinase that is activated by tumor necrosis factor-alpha (TNF-alpha) and specifically activates c-Jun N-terminal kinase (JNK) on TNF-alpha stimulation
Kim et al., Biochem Biophys Res Commun 2010 (Neovascularization, Pathologic) : NBBA suppressed TNF-alpha induced c-Jun N-terminal kinase phosphorylation, which resulted in suppression of transcription of NF-kappaB and its target genes, including interleukin-8, interleukin-1alpha, and epidermal growth factor
Yang et al., Atherosclerosis 2010 : In cultured human aortic endothelial cells, TNF-alpha increased ET-1 through AP-1 and NF-kappaB, whereas MPA attenuated it by reducing both AP-1 and NF-kappaB DNA binding activities ... N-acetylcysteine, SP600125 ( JNK inhibitor ) and SB203580 ( p38 MAPK inhibitor ) attenuated TNF-alpha induced DNA binding activities of both AP-1 and NF-kappaB
Sullivan et al., J Cell Mol Med 2009 : TNF-alpha induced increased levels of c-Jun and C-Fos in the nucleus accompanied by phosphorylation of c-Jun ... Together, these results suggest that TNF-alpha induces expression and DNA binding of AP-1 resulting in increased transcription of the TGF-beta(1) gene
Natalicchio et al., Endocrinology 2010 : Exendin-4 prevents c-Jun N-terminal protein kinase activation by tumor necrosis factor-alpha (TNFalpha) and inhibits TNFalpha induced apoptosis in insulin secreting cells
Zhang et al., Can J Physiol Pharmacol 2010 (Calcium Signaling...) : Conversely, activation of c-Jun NH2-terminal kinase 1 (JNK1) negatively regulates TNF-alpha production through inhibition of ERK1/2 and p38 MAPK activity
Wang et al., J Med Invest 2010 (MAP Kinase Signaling System...) : Strategies that neutralize TNF-alpha as well as inhibitors of MAPK-NF-kappa B- and/or AP-1 dependent pathways may be useful for suppressing the MMP-9 effect and thus preventing multiple organ failure in severe influenza
Lee et al., J Cell Physiol 2010 (MAP Kinase Signaling System) : On the other hand, TNF-alpha stimulated the phosphorylation of c-Src, EGFR, Akt, JNK1/2, and c-Jun , which were inhibited by pretreatment with Gö6983 ... Pretreatment with the inhibitor of JNK1/2 ( SP600125 ) but not the inhibitor of MEK1/2 ( U0126 ), p38 MAPK ( SB202190 ), or PI3K ( LY294002 ), markedly inhibited TNF-alpha induced c-Jun mRNA levels
Baregamian et al., Oxidative medicine and cellular longevity 2009 (Enterocolitis, Necrotizing...) : Tumor necrosis factor-alpha and apoptosis signal regulating kinase 1 control reactive oxygen species release, mitochondrial autophagy, and c-Jun N-terminal kinase/p38 phosphorylation during necrotizing enterocolitis
Shibata et al., Vet Immunol Immunopathol 2011 : In a cell line of canine epidermal keratinocyte, CPEK, stimulation with TNF-a induced not only the activation of nuclear factor-kappa B ( NF-?B ) but also the phosphorylation of c-Jun-N-terminal kinase (JNK) and mitogen activated protein kinase p38 ( p38 )
Park et al., Int J Mol Med 2011 : GM3 synthase gene expression markedly suppressed the TNF-a stimulated transcriptional activity of activator protein-1 (AP-1) and nuclear factor-?B ( NF-?B ), which are the controlling factors of MMP-9 expression
Zhang et al., Mol Biol Cell 2011 : Tumor necrosis factor a (TNF-a) receptor associated factor 2 ( TRAF2 ) regulates activation of the c-Jun N-terminal kinase (JNK)/c-Jun and the inhibitor of ?B kinase ( IKK ) /nuclear factor ?B ( NF-?B ) signaling cascades in response to TNF-a stimulation
Seidel et al., Schweiz Med Wochenschr 2010 : PDGF-BB and TNF-a activated AP-1 , which was also inhibited by DMF
Eda et al., Rheumatol Int 2011 (MAP Kinase Signaling System) : IL-1ß and TNF-a activated the intracellular mitogen activated protein kinases ( MAPKs ) : p44/42 MAPK, p38, and c-Jun N-terminal kinase (JNK) as well as nuclear factor-?B ( NF-?B ) in osteoblasts
Kim et al., J Pharmacol Exp Ther 2011 : Furthermore, luteolin inhibited TNF-a induced phosphorylation of mitogen activated protein kinase/extracellular signal regulated kinase ( ERK ) kinase 1/ERK/p90 ( RSK ), mitogen activated protein kinase kinase 4/c-Jun N-terminal kinase/c-Jun , and Akt/p70 ( S6K )
Chen et al., Vascul Pharmacol 2011 : However, ZLJ-6 did not affect TNF-a induced extracellular signal regulated kinases ( ERK1/2 ), c-Jun N-terminal kinases (JNK) and p38 phosphorylation
Tsai et al., J Investig Med 2011 (Inflammation...) : Its suppressive effect on TNF-a , I-309, and IP-10 may, at least in part, involve the down-regulation of LPS induced MKK4-JNK-c-Jun expression
Kim et al., Vascul Pharmacol 2012 (Atherosclerosis...) : Furthermore, sulforaphane inhibited NK-?B and AP-1 activation induced by TNF-a
Zhou et al., Arterioscler Thromb Vasc Biol 2012 (Aortic Diseases...) : Smooth muscle a-actin levels were increased with age in SOD2+/- versus wild-type SMCs. Aged SOD2+/- SMCs had attenuated insulin-like growth factor-1 induced Akt and Forkhead box O3a phosphorylation and prolonged tumor necrosis factor-a induced Jun N-terminal kinase 1 activation
Scudiero et al., J Biol Chem 2012 : Tumor necrosis factor (TNF) receptor associated factor 7 is required for TNFa induced Jun NH2-terminal kinase activation and promotes cell death by regulating polyubiquitination and lysosomal degradation of c-FLIP protein
Herfs et al., Am J Respir Cell Mol Biol 2012 (Hyperplasia...) : Using immunohistological techniques, we showed a higher epithelial expression of TNF-a , IL-1ß, and IL-6, as well as an activation of NF-?B and activator protein-1/mitogen activated protein kinase signaling pathways in the respiratory tract of smoking patients, compared with the normal ciliated epithelium of nonsmoking patients
Bayardo et al., Clin Exp Immunol 2012 (Celiac Disease) : The use of selective inhibitors of signalling pathways revealed that induction of TG2 by IFN-? was mediated by phosphoinositide 3-kinase (PI3K), while c-Jun N-terminal kinase (JNK) and p38 mitogen activated protein kinase ( MAPK ) were required for TNF-a activation
Tsou et al., J Cell Biochem 2012 (Osteoarthritis) : TNF-a mediated AP-1-luciferase activity and c-Jun binding to the AP-1 element were inhibited by TNFR1 Ab, thioredoxin, SP600125, and SB203580
Ji et al., Arterioscler Thromb Vasc Biol 2012 : The proinflammtory cytokine tumor necrosis factor (TNF) , primarily via TNF receptor 1 (TNFR1), induces nuclear factor-?B ( NF-?B ) -dependent cell survival, and c-Jun N-terminal kinase (JNK) and caspase dependent cell death, regulating vascular endothelial cell ( EC ) activation and apoptosis
Jude et al., Am J Physiol Lung Cell Mol Physiol 2012 (Asthma...) : In human ASM ( HASM ) cells, TNF-a induces CD38 expression through activation of MAPKs, NF-?B, and AP-1 , and its expression is differentially elevated in cells from asthmatic patients compared with cells from nonasthmatic subjects
Clarke et al., Mol Cell Proteomics 2013 (MAP Kinase Signaling System) : Mixed-effects modeling analysis of our data was vital for ascertaining that IL-1a and TGF-a treatment increased the activities of more pathways than IL-6 and TNF-a and that TGF-a and TNF-a increased p38 MAPK and c-Jun N-terminal kinase (JNK) phospho-protein levels in a synergistic manner
Nishikawa et al., J Cell Biochem 2013 (Drug-Induced Liver Injury, Chronic...) : TNF-a also induced the phosphorylation of Jun N-terminal kinase (JNK) and c-Jun, and the morphogenesis was inhibited by SP600125, a specific JNK inhibitor
Yanagisawa et al., Mol Nutr Food Res 2012 (Insulin Resistance) : Gen inhibited the TNF-a induced c-Jun-NH ( 2 ) -terminal kinase ( JNK ) signaling that is involved in adiponectin expression
Kuntzsch et al., PloS one 2012 (Inflammation...) : It inhibited c-Jun N-terminal kinase (JNK) activation induced by dexamethasone and/or TNF-a and increased levels of GR localized to the nucleus
Kanaji et al., J Vasc Res 2013 (MAP Kinase Signaling System...) : TNF-a activated c-Jun N-terminal kinase (JNK) , extracellular signal regulated kinases 1 and 2 ( ERK1/2 ), and p38
Koo et al., Cell Biol Int 2013 : TNF-a increased DNA binding activity of AP-1 and NF-?B, whereas both AP-1 and NF-?B decoy oligodeoxynucleotides downregulated TNF-a induced MCP-1 mRNA expression ... MPA and Syk inhibitor attenuated TNF-a induced DNA binding activity of NF-?B and AP-1
Yang et al., Biochem Pharmacol 2013 : Finally, we showed that, in H9c2 cells, TNF-a stimulated AP-1 promoter activity, c-Jun mRNA expression, and c-Jun phosphorylation were attenuated by PP1, AG1478, AG1296, LY294002, SB202190, SP600125, or U0126
Dulos et al., Clin Exp Rheumatol 2013 (Arthritis, Rheumatoid...) : TNF-a induced phosphorylation of JNK and c-Jun was sustained by p38 inhibitors in monocytes, primary macrophages and FLS
Ha et al., Int J Biol Macromol 2013 : In the mechanism of LGC, while extracellular signal regulated kinase ( ERK ) was important for the induction of TNF-a, IL-1ß and IL-8, the phosphorylation of C-Jun NH2-termianl kinase (JNK) contributed to the induction of TNF-a and IL-1ß to a greater degree
Das et al., Mol Cell Biochem 1995 (Adenocarcinoma...) : Likewise, some of the thiol modifying compounds inhibited AP-1 activation by TNF alpha or IL-1, whereas others did not
Lengyel et al., Biochim Biophys Acta 1995 : Stimulation of urokinase expression by TNF-alpha requires the activation of binding sites for the AP-1 and PEA3 transcription factors
Tran-Thi et al., Hepatology 1995 : Using primary cultures of rat Kupffer cells the role of NF-kappa B and activator protein 1 (AP-1) in the expression of the tumor necrosis factor-alpha (TNF-alpha) gene by lipopolysaccharide (LPS) was investigated ... The results indicate a direct participation of NF-kappa B in the regulation of TNF-alpha synthesis and a differential effect of LPS on NF-kappa B and AP-1 , respectively
Klampfer et al., Mol Cell Biol 1994 : Consistent with this possibility, IL-1 and TNF-alpha markedly increase the binding of Fos and Jun to the AP-1 site, and NF-IL6 activates the native TSG-6 promoter
Adcock et al., Life Sci 1994 : The interaction of the transcription factors, activator protein 1 (AP-1) and nuclear factor kappa from B cells ( NF kappa B ) with DNA and glucocorticoid receptors was analysed by gel mobility shift assays following stimulation by tumour necrosis factor alpha (TNF alpha) and a phorbol ester ( PMA ) that activates protein kinase C. PMA and TNF alpha both caused significant ( 180-340 % ) increases in AP-1 and NF kappa B DNA binding which peaked at 15 minutes and decreased to a constant elevated level at between 1-3 hrs and was sustained for 24hrs
Brach et al., Leukemia 1993 (Leukemia, Myeloid, Acute) : The mitogenic response of AML blasts to tumor necrosis factor-alpha requires functional c-jun/AP-1
Hattori et al., Am J Physiol 1993 (Acute-Phase Reaction...) : In addition, IL-6, tumor necrosis factor-alpha , and IL-1 beta, cytokine regulators of the acute phase response, stimulated expression of an AP-1 responsive reporter gene introduced by DNA mediated transfection into adult rat hepatocytes in primary culture
Tsai et al., Mol Cell Biol 1996 : Tumor necrosis factor alpha gene regulation in activated T cells involves ATF-2/Jun and NFATp
Tsai et al., Mol Cell Biol 1996 (Lymphoma) : Cell-type-specific regulation of the human tumor necrosis factor alpha gene in B cells and T cells by NFATp and ATF-2/JUN
Zhao et al., Mol Endocrinol 1996 : These results suggest that TNF alpha , probably acting through ceramide formation, stimulates the binding of both c-fos and c-jun to the AP-1 element upstream of exon 1.4
Schwenger et al., Proc Natl Acad Sci U S A 1997 : Sodium salicylate induces apoptosis via p38 mitogen activated protein kinase but inhibits tumor necrosis factor induced c-Jun N-terminal kinase/stress activated protein kinase activation
Baumruker et al., Int Arch Allergy Immunol 1997 : Nuclear factor of activated T cells ( NF-AT ) and AP1 transcription factors together mediate the activation of TNF alpha transcription in mast cells upon IgE plus antigen stimulation which, in contrast to the degranulation reaction and leukotriene synthesis, is independent of phosphoinositol-3-kinase
Min et al., J Immunol 1997 : In human endothelial cells, TNF rapidly induces N-terminal domain phosphorylation of both c-Jun and ATF2
Wang et al., Surgery 1998 (Carcinoma, Hepatocellular) : TNF-alpha increased c-jun and junD mRNA and c-Jun and JunD protein levels, as well as AP-1 binding activity ... TNF-alpha and IL-6 induce a differential pattern of AP-1 expression in HepG2 cells ; TNF-alpha increases both c-Jun and JunD, whereas IL-6 stimulates only c-Jun
Auer et al., Mol Biol Cell 1998 : Glucose, TNFalpha , or HGF treatments increased phosphorylation of c-Jun at serine 63 in the transactivation domain and stimulated hepatocyte DNA synthesis
Haridas et al., J Immunol 1998 (Breast Neoplasms) : Overexpression of the p80 TNF receptor leads to TNF dependent apoptosis, nuclear factor-kappa B activation, and c-Jun kinase activation ... HeLa cells, which express only p60 receptors, were transfected with p80 receptor cDNA and then examined for apoptosis, NF-kappa B activation, and c-Jun kinase activation induced by TNF and by p60 or p80 receptor-specific muteins
Zagariya et al., Mol Cell Biol 1998 : Our data demonstrate that the TNF alpha gene is regulated by the interaction of the ubiquitous AP-1 complex protein c-Jun and the monocyte/macrophage enriched transcription factor C/EBPbeta and that this interaction contributes to the expression of the cellular TNF alpha gene in myelomonocytic cells
Short et al., Mol Biol Cell 1998 : In addition, tumor necrosis factor alpha activation of c-Jun kinase (JNK) was also much more robust in anchored cells
Shau et al., Biochem Biophys Res Commun 1998 : Tumor necrosis factor-alpha (TNF) activates the expression of activator protein-1 (AP-1) responsive genes ... We show here that over-expression of TxP-1 blocks TNF induced AP-1 activation in endothelial ECV304 cells, which was demonstrated by three independent experimental protocols : electromobility shift assay with AP-1 oligonucleotide probe ; reporter gene expression with AP-1 binding site, and interleukin-8 production, which is dependent on AP-1
Manna et al., J Immunol 1998 : TNF induced activation of another nuclear transcription factor, AP-1 , was suppressed by IL-13 ... Thus, overall, these results demonstrate that IL-13 is a potent inhibitor of TNF mediated activation of NF-kappa B, AP-1 , and apoptosis, which may contribute to its previously described immunosuppressive and anti-inflammatory effects
Lakshminarayanan et al., J Biol Chem 1998 : H2O2 and tumor necrosis factor-alpha induce differential binding of the redox-responsive transcription factors AP-1 and NF-kappaB to the interleukin-8 promoter in endothelial and epithelial cells ... H2O2 activated AP-1 but not NF-kappaB in A549, whereas TNFalpha activated AP-1 as well as NF-kappaB ... In HMEC-1, TNFalpha activated NF-kappaB but not AP-1 , while H2O2 did not activate either transcription factor ... Supershift analysis revealed H2O2 as well as TNFalpha induced AP-1 complexes containing c-Fos and JunD
Lee et al., Eur J Immunol 1998 : ROI have been implicated in the activation of NF-kappaB as well as c-Jun N-terminal kinase (JNK) in response to IL-1 and TNF-alpha stimulation
Hoffmeyer et al., J Biol Chem 1999 : Here we show that extracellular signal regulated kinase ( ERK ), c-Jun N-terminal kinase (JNK) , and p38-mitogen activated protein kinase ( MAPK ) pathways control the transcription and synthesis of TNF-alpha in A3.01 T cells that produce the cytokine upon T cell activation by costimulation with 12-O-tetradecanoylphorbol-13-acetate ( TPA ) and ionomycin
Rahman et al., J Biol Chem 1999 : Gel shift and supershift analysis showed that TNF-alpha increased AP-1 DNA binding which was predominantly formed by dimers of c-Jun