Suzuki et al., Biomed Res 2008
(Carcinoma, Pancreatic Ductal...) :
Here, we show that tumor necrosis factor-alpha (TNF-alpha) suppressed the expression of both Per1 and Per3 in MIA-PaCa2 cells, a human pancreatic cancer cell line
Petrzilka et al., J Biol Rhythms 2009
(MAP Kinase Signaling System) :
The early effect of TNF-alpha on the clock gene Per1 is dependent on p38, mitogen activated protein kinase ( MAPK ), and/or calcium signaling, whereas the effect on Dbp is independent of p38 MAPK, but also involves calcium signaling