Joo et al., Biochem Biophys Res Commun 2003
(Hepatoblastoma...) :
Transient expression of NF-kappaB ( p65 ) increased S100A6 promoter activity and expression of inhibitor of NF-kappaB ( IkappaBalpha ) decreased TNFalpha induced S100A6 promoter activity ... These results suggest that NF-kappaB transcription factor contributes to the activation of S100A6 gene expression in response to TNFalpha in HepG2 cells
Tsoporis et al., J Biol Chem 2008
(Inflammation) :
Tumor necrosis factor-alpha induced the maximal S100A6 promoter and transcription factor NF-kappaB ( p65 subunit ) ... These results demonstrate that S100A6 is induced by tumor necrosis factor-alpha via an NF-kappaB dependent mechanism, serving a role in homeostasis to limit tumor necrosis factor-alpha induced apoptosis by regulating p53 phosphorylation
Tamai et al., Blood cancer journal 2011
:
Upregulation of S100A6 expression and inhibition of the p53-caspase 8-caspase 3 pathway were observed only in MLL-AFF1 positive ALL cell lines in the presence of TNF-a