We have a suspicion that you are an automated web bot software, not a real user. To keep our site fast for other users, we have slowed down this page. The slowdown will gradually disappear. If you think this is a mistake, please contact us at genome-www@soe.ucsc.edu. Also note that all data for hgGeneGraph can be obtained through our public MySQL server and all our software source code is available and can be installed locally onto your own computer. If you are unsure how to use these resources, do not hesitate to contact us.
UCSC Genome Browser Gene Interaction Graph
Gene interactions and pathways from curated databases and text-mining

◀ Back to TNF

SDC4 — TNF

Text-mined interactions from Literome

Zhang et al., J Biol Chem 1999 : In vitro studies demonstrated that TNF-alpha induced endothelial cell syndecan-4 expression by both increasing syndecan-4 gene expression in an NF-kappaB dependent manner and by prolonging syndecan-4 mRNA half-life
Zhang et al., Nan Fang Yi Ke Da Xue Xue Bao 2007 : [Tumor necrosis factor-alpha regulates the proliferation and syndecan-4 expression of human umbilical vein endothelial-like cells cultured in vitro ] ... To investigate the effects of tumor necrosis factor-alpha(TNF-alpha) on syndecan-4 protein expression and proliferation of cultured human umbilical vein endothelial-like cells ( HUVECs ) in vitro ... The expression of syndecan-4 protein was significantly enhanced by TNF-alpha
Teixé et al., Mol Immunol 2008 : However, cross linking of cell bound syndecan-2 or syndecan-4 via immobilized antibodies blocked proliferation and decreased TNF production of T cells in the presence of optimal levels of anti-CD3
Zhang et al., Nan Fang Yi Ke Da Xue Xue Bao 2010 : The expression of syndecan-4 protein in the VSMCs was significantly enhanced by 20 ng/ml TNF-alpha ( P < 0.01 ). Pravastatin alone did not affect the expression of syndecan-4 protein ( P > 0.05 ), but significantly inhibited TNF-alpha induced enhancement of syndecan-4 protein expression ( P < 0.01 )
Wang et al., J Biol Chem 2011 : The goal of the investigation was to study if TNF-a and IL-1ß regulate syndecan-4 (SDC4) expression, and if SDC4 was responsible for promoting aggrecan degradation through controlling ADAMTS activity in nucleus pulposus cells of the intervertebral disc ... We conclude that in nucleus pulposus, TNF-a and IL-1ß regulate SDC4 expression, which plays a key role in pathogenesis of degenerative disc disease by promoting aggrecan degradation by ADAMTS-5
Tanino et al., Am J Respir Cell Mol Biol 2012 (Lung Injury...) : Studies performed using BEAS-2B cells showed that pretreatment with heparin and syndecan-4 decreased the expression of CXCL8 mRNA in response to LPS and TNF-a
Okuyama et al., J Biochem 2013 : To elucidate these mechanisms in detail, we examined syndecan-4 upregulation by TNF-a in the endothelium-like EAhy926 cell