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ATF3 — IL6
Text-mined interactions from Literome
Kim et al., BMC bioinformatics 2007
:
For the third, it allows the correct identification, from noisy data, of the negative
regulation of (
IL)-6 and ( IL)-12b by
ATF3
Takii et al., J Immunol 2010
(Fever) :
Heat shock transcription factor 1 (HSF1) activated by heat shock induced the expression of activating transcription factor (ATF) 3, a negative regulator of IL-6, and
ATF3 was
necessary for heat mediated suppression of
IL-6 , indicating a fever mediated feedback loop consisting of HSF1 and ATF3
Ambade et al., Hepatology 2012
(Disease Models, Animal...) :
We show that HSF1 indirectly
regulates IL-6 by the induction of another transcription factor,
activating transcription factor 3
Aung et al., Arterioscler Thromb Vasc Biol 2013
(Inflammation) :
Small interfering RNA ( siRNA ) -mediated inhibition of
ATF3 blocked lipolysis products induced transcription of E-selectin and interleukin-8, but not
interleukin-6 or nuclear factor-?B