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IL17A — STAT3
Pathways - manually collected, often from reviews:
-
NCI Pathway Database IL23-mediated signaling events:
STAT3 (dimer ) complex (STAT3)
→
IL17 (IL17A)
(transcription, activates)
Aggarwal et al., J Biol Chem 2003*, Langrish et al., J Exp Med 2005, Park et al., Nat Immunol 2005*, Harrington et al., Nat Immunol 2005, Cho et al., J Immunol 2006
Evidence: mutant phenotype, other species
Text-mined interactions from Literome
Cho et al., J Immunol 2006
(Arthritis...) :
STAT3 and NF-kappaB signal pathway is
required for IL-23 mediated
IL-17 production in spontaneous arthritis animal model IL-1 receptor antagonist-deficient mice
Rahman et al., J Immunol 2006
(Asthma...) :
In addition,
IL-17A mediated rapid phosphorylation of MAPK ( p38, JNK, and p42/44 ERK ) and
STAT-3 but not STAT-6 or STAT-5 in ASM cells
Wei et al., J Biol Chem 2007
:
IL-21 is produced by Th17 cells and drives
IL-17 production in a
STAT3 dependent manner
Caruso et al., Eur J Immunol 2008
(Helicobacter Infections) :
Treatment of normal gastric lamina propria mononuclear cells ( LPMC ) with IL-23 enhanced Stat3 activation and IL-17 secretion, and pharmacological inhibition of
Stat3 prevented IL-23-driven
IL-17 synthesis
Yang et al., Immunity 2008
(Encephalomyelitis, Autoimmune, Experimental...) :
STAT3 regulated Foxp3 downregulation, whereas
STAT3 , RORgamma, and ROR* were
required for
IL-17 expression in Treg cells
Huber et al., Proc Natl Acad Sci U S A 2008
:
Current dogma proposes that IL-6 induces IL-21, which, in a
STAT3 dependent manner, amplifies its own transcription, contributes to
IL-17 production, and, moreover, promotes the expression of the IL-23 receptor
Saleh et al., J Immunol 2009
:
IL-17A mediated a rapid phosphorylation of
STAT3 but not STAT6 or STAT5 in ASM cells ... Interestingly, disruption of STAT3 activity with the SH2 domain binding peptide, but not with control peptide, results in a significant reduction of
IL-17A mediated
STAT3 phosphorylation and CCL11 promoter activity ... Finally,
IL-17A induced
STAT3 phosphorylation was sensitive to pharmacological inhibitors of JAK2 and ERK1/2
Guo et al., Proc Natl Acad Sci U S A 2009
:
Similarly, Th17 cells produce
IL-17A in
response to IL-1beta and a
STAT3 activator and Th1 cells produce IFNgamma in response to IL-18 and a STAT4 inducer
da Matta Guedes et al., PLoS Negl Trop Dis 2010
(Chagas Cardiomyopathy) :
Moreover, the results showed that
IL-17 regulates T-bet, RORgammat and
STAT-3 expression in the heart, showing that IL-17 controls the differentiation of Th1 cells in infected mice
Park et al., Immunol Lett 2011
(Arthritis, Experimental...) :
The presence of GSPE decreased the levels of IL-21, IL-22, IL-26 and
IL-17 production by human CD4 ( + ) T cells in a
STAT3 dependent manner
Gislette et al., TheScientificWorldJournal 2010
(Neoplasms...) :
IL-17 could
activate Src/PI3K, MAPK,
Stat3 , and PKC, resulting in carcinogenesis
Jager et al., J Neuroimmunol 2011
(Encephalomyelitis, Autoimmune, Experimental) :
SOCS1-KIR also blocked IL-23 and
IL-17A activation of
STAT3
Yang et al., Nat Immunol 2011
:
Whereas
STAT3 induced
IL-17 and the transcription factor ROR?t and inhibited the transcription factor Foxp3, IL-2 inhibited IL-17 independently of Foxp3 and ROR?t
Wang et al., J Clin Pathol 2012
(Hemangioma...) :
Based on these findings, we propose that
IL-17 may mediate the angiogenesis in a
IL-6-Stat3 dependent manner and play an important role in the pathophysiology of hepatic haemangioma
Gu et al., Molecular cancer 2011
(Carcinoma, Hepatocellular...) :
IL-17 induces AKT dependent
IL-6/JAK2/STAT3 activation and tumor progression in hepatocellular carcinoma
Choi et al., J Invest Dermatol 2013
(Hypopigmentation) :
Despite the lack of a direct inhibition of melanin pigment synthesis, IFN? and
IL-17A increased the synthesis of an antimelanogenic cytokine IL-6 in NHMs. IFN? activated signal transducers and activators of transcription 1 ( STAT1 ) and
STAT3 phosphorylation in NHMs, and IL-4 increased the STAT3 and STAT6 phosphorylation
Mukherjee et al., Shock 2012
(Disease Models, Animal...) :
STAT3 mediated
IL-17 production by postseptic T cells exacerbates viral immunopathology of the lung
Afzali et al., Eur J Immunol 2013
:
Importantly, we find that
IL-17 production is
STAT3 dependent , with Treg cells from patients with STAT3 mutations unable to make IL-17