Gene interactions and pathways from curated databases and text-mining

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IL17A — STAT3

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Cho et al., J Immunol 2006 (Arthritis...) : STAT3 and NF-kappaB signal pathway is required for IL-23 mediated IL-17 production in spontaneous arthritis animal model IL-1 receptor antagonist-deficient mice
Rahman et al., J Immunol 2006 (Asthma...) : In addition, IL-17A mediated rapid phosphorylation of MAPK ( p38, JNK, and p42/44 ERK ) and STAT-3 but not STAT-6 or STAT-5 in ASM cells
Wei et al., J Biol Chem 2007 : IL-21 is produced by Th17 cells and drives IL-17 production in a STAT3 dependent manner
Caruso et al., Eur J Immunol 2008 (Helicobacter Infections) : Treatment of normal gastric lamina propria mononuclear cells ( LPMC ) with IL-23 enhanced Stat3 activation and IL-17 secretion, and pharmacological inhibition of Stat3 prevented IL-23-driven IL-17 synthesis
Yang et al., Immunity 2008 (Encephalomyelitis, Autoimmune, Experimental...) : STAT3 regulated Foxp3 downregulation, whereas STAT3 , RORgamma, and ROR* were required for IL-17 expression in Treg cells
Huber et al., Proc Natl Acad Sci U S A 2008 : Current dogma proposes that IL-6 induces IL-21, which, in a STAT3 dependent manner, amplifies its own transcription, contributes to IL-17 production, and, moreover, promotes the expression of the IL-23 receptor
Saleh et al., J Immunol 2009 : IL-17A mediated a rapid phosphorylation of STAT3 but not STAT6 or STAT5 in ASM cells ... Interestingly, disruption of STAT3 activity with the SH2 domain binding peptide, but not with control peptide, results in a significant reduction of IL-17A mediated STAT3 phosphorylation and CCL11 promoter activity ... Finally, IL-17A induced STAT3 phosphorylation was sensitive to pharmacological inhibitors of JAK2 and ERK1/2
Guo et al., Proc Natl Acad Sci U S A 2009 : Similarly, Th17 cells produce IL-17A in response to IL-1beta and a STAT3 activator and Th1 cells produce IFNgamma in response to IL-18 and a STAT4 inducer
da Matta Guedes et al., PLoS Negl Trop Dis 2010 (Chagas Cardiomyopathy) : Moreover, the results showed that IL-17 regulates T-bet, RORgammat and STAT-3 expression in the heart, showing that IL-17 controls the differentiation of Th1 cells in infected mice
Park et al., Immunol Lett 2011 (Arthritis, Experimental...) : The presence of GSPE decreased the levels of IL-21, IL-22, IL-26 and IL-17 production by human CD4 ( + ) T cells in a STAT3 dependent manner
Gislette et al., TheScientificWorldJournal 2010 (Neoplasms...) : IL-17 could activate Src/PI3K, MAPK, Stat3 , and PKC, resulting in carcinogenesis
Jager et al., J Neuroimmunol 2011 (Encephalomyelitis, Autoimmune, Experimental) : SOCS1-KIR also blocked IL-23 and IL-17A activation of STAT3
Yang et al., Nat Immunol 2011 : Whereas STAT3 induced IL-17 and the transcription factor ROR?t and inhibited the transcription factor Foxp3, IL-2 inhibited IL-17 independently of Foxp3 and ROR?t
Wang et al., J Clin Pathol 2012 (Hemangioma...) : Based on these findings, we propose that IL-17 may mediate the angiogenesis in a IL-6-Stat3 dependent manner and play an important role in the pathophysiology of hepatic haemangioma
Gu et al., Molecular cancer 2011 (Carcinoma, Hepatocellular...) : IL-17 induces AKT dependent IL-6/JAK2/STAT3 activation and tumor progression in hepatocellular carcinoma
Choi et al., J Invest Dermatol 2013 (Hypopigmentation) : Despite the lack of a direct inhibition of melanin pigment synthesis, IFN? and IL-17A increased the synthesis of an antimelanogenic cytokine IL-6 in NHMs. IFN? activated signal transducers and activators of transcription 1 ( STAT1 ) and STAT3 phosphorylation in NHMs, and IL-4 increased the STAT3 and STAT6 phosphorylation
Mukherjee et al., Shock 2012 (Disease Models, Animal...) : STAT3 mediated IL-17 production by postseptic T cells exacerbates viral immunopathology of the lung
Afzali et al., Eur J Immunol 2013 : Importantly, we find that IL-17 production is STAT3 dependent , with Treg cells from patients with STAT3 mutations unable to make IL-17