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AKT1 — BMP2

Text-mined interactions from Literome

Sugimori et al., J Bone Miner Metab 2005 : We investigated the involvement of phosphatidylinositol 3-kinase (PI3K)/Akt mediated NF-kappaB activation by BMP-2 stimulation in the modulation of this antiapoptotic process in a chondrocytic cell line, N1511
Itoh et al., J Gastroenterol 2006 : Furthermore, BMP2 inhibited MSE1 cell proliferation in MTS assays and suppressed AKT phosphorylation
Segrelles et al., Mol Biol Cell 2008 (Nails, Malformed...) : Constitutively active Akt induces ectodermal defects and impaired bone morphogenetic protein signaling
Wu et al., Eur J Pharmacol 2008 : The transcriptional regulation of BMP-2 by naringin was mediated by phosphorylation of Akt and activation of the activator protein-1 (AP-1) components c-Fos and c-Jun
Fong et al., J Cell Physiol 2008 (Chondrosarcoma) : BMP-2 increased the phosphorylation of p85 subunit of PI3K and serine 473 of Akt ... Taken together, these results suggest that the BMP-2 acts through PI3K/Akt , which in turn activates IKKalpha/beta and NF-kappaB, resulting in the activations of beta1 integrin and contributing the migration of human chondrosarcoma cells
Graham et al., Prostate 2009 (Neoplasm Metastasis...) : PI3K/Akt dependent transcriptional regulation and activation of BMP-2-Smad signaling by NF-kappaB in metastatic prostate cancer cells ... Selective inhibition of PI3K/Akt suppressed the NF-kappaB induced BMP-2 promoter activity
Lee et al., Stem Cells 2009 : In addition, BMP-4 induced Akt phosphorylation
Johnsen et al., Cancer Res 2009 (Adrenal Cortex Neoplasms...) : This growth inhibitory effect was associated with BMP dependent reduction of AKT phosphorylation under baseline conditions and under insulin-like growth factor costimulation
Graham et al., Cancer Sci 2010 (Neoplasm Metastasis...) : We recently reported that phosphoinositide 3-kinase (PI3K)/protein kinase B ( Akt ) mediates transcriptional regulation and activation of bone morphogenetic protein (BMP)-2 signaling by nuclear factor (NF)-kappaB in bone metastatic prostate cancer cells
Mandal et al., Endocrinology 2009 : Inhibition of PI3K/Akt signaling blocked the binding of Smads 1/5 to the CSF-1 BMP-responsive element present in the CSF-1 promoter, resulting in attenuation of Smad dependent CSF-1 transcription
Perez et al., J Cell Biol 2011 (Neointima) : We show that BMP-2 , in a phospho-Akt dependent manner, induces ßC transcriptional activity to produce fibronectin, which then activates integrin linked kinase 1 (ILK-1) via a4-integrins
Choi et al., Biochem Biophys Res Commun 2011 : These results suggest that Akt activity enhances the osteogenic function of Osterix, at least in part, through protein stabilization and that BMP-2 regulates the osteogenic function of Osterix, at least in part, through Akt
Liu et al., Biochem Biophys Res Commun 2013 : Furthermore, in the presence of exogenous BMP-2 , PI3K and Akt inhibitors blocked Runx2 and osteocalcin expression, although BMP-2 did not activate Akt
Ueki et al., Glia 2013 : Interestingly, BMP/Smad1/5/8 activation downstream of PI3K/AKT signaling was also necessary for robust Müller glial proliferation, though activation of BMP/Smad1/5/8 signaling alone failed to stimulate their proliferation
Ghosh-Choudhury et al., J Biol Chem 2013 : Remarkably, inhibition of c-Abl significantly suppressed BMP-2 stimulated PI 3-kinase activity and its downstream Akt phosphorylation