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FOXP3 — IL17D
Text-mined interactions from Literome
Huber et al., Int Immunol 2008
:
Our results demonstrate that
IL-27 inhibits the acquisition of the Treg phenotype at the level of
Foxp3 , CD25 and CTLA-4 ( CD152 ) expression as well as the suppressive function
Batten et al., J Immunol 2008
:
Cutting edge :
IL-27 is a potent
inducer of IL-10 but not
FoxP3 in murine T cells
Cox et al., J Exp Med 2011
(Colitis) :
Indeed,
IL-27 suppressed
Foxp3 induction in vitro and in an ovalbumin dependent tolerization model in vivo
Wojno et al., J Immunol 2011
(Inflammation) :
Although previous studies have shown that regulatory T cells ( Tregs ) express the IL-27R, and that
IL-27 inhibits
forkhead box P3 upregulation in vitro, little is known about how IL-27 influences Tregs in vivo ... Although
IL-27 did not
cause mature Tregs to downregulate
forkhead box P3 , transgenic overexpression in vivo limited the size of a differentiating Treg population in a bone marrow chimera model, which correlated with reduced production of IL-2, a vital cytokine for Treg maintenance