Gene interactions and pathways from curated databases and text-mining

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ESR1 — INS

Text-mined interactions from Literome

Alonso-Magdalena et al., PloS one 2008 (Calcium Signaling) : Pancreatic insulin content regulation by the estrogen receptor ER alpha
Wong et al., Proc Natl Acad Sci U S A 2010 : Extranuclear estrogen receptor-alpha stimulates NeuroD1 binding to the insulin promoter and favors insulin synthesis ... ERalpha also enhances insulin synthesis in cultured islets
Richardson et al., Growth Factors 2011 (Breast Neoplasms) : Insulin-like growth factor-2 (IGF-2) activates estrogen receptor-a and -ß via the IGF-1 and the insulin receptors in breast cancer cells
Chaudhuri et al., Arch Surg 1986 (Diabetes Mellitus, Experimental...) : To evaluate the effect of insulin on a receptor positive tumor, we examined the direct effect of insulin on an estrogen receptor and its subsequent biologic effect on a receptor positive endometrial carcinoma model in vitro and in vivo
Siegel et al., Neuroendocrinology 1979 (Diabetes Mellitus, Experimental...) : 24 h insulin deprivation resulted in a signficant reduction of cell nuclear estrogen receptor levels in hypothalamus-preoptic area of rats sacrificed 26 h after EB administration
Moore et al., J Biol Chem 1981 (Breast Neoplasms) : An insulin effect on cytoplasmic estrogen receptor in the human breast cancer cell line MCF-7
Patrone et al., Mol Endocrinol 1996 (Neuroblastoma) : These effects were shown to be due to an insulin dependent activation of the unliganded estrogen receptor ... The finding that, in neuroblastoma cells, selected signal transduction systems are involved in the insulin dependent activation of estrogen receptor is of particular interest considering that estrogen receptor might restrict the role played by insulin during the differentiation of neural cells and interfere with its proliferative potential while allowing its regulation of other functions related to cell survival
Patrone et al., Mol Endocrinol 1998 (Carcinoma, Renal Cell...) : However, in this cell line Ser 122 is not necessary for insulin dependent activation of unliganded ER alpha ... The two cofactors for steroid receptors RIP 140 and SRC-1 do not seem to be specifically involved in the insulin induced ER alpha transactivation