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INS — NPPA

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Galitzky et al., J Lipid Res 2001 (Obesity) : h-ANP induced a marked and similar increase in glycerol and nonesterified fatty acids, and a weak increase in insulin plasma levels in lean and obese men
Ohno et al., J Hum Hypertens 2001 (Hyperinsulinism...) : We investigated the relationship between sodium related parameters and insulin sensitivity, and the effects of euglycaemic hyperinsulinaemia on cyclic guanosine monophosphate ( cGMP ) and atrial natriuretic peptide (ANP) levels in 17 young, lean, normotensive male subjects, who displayed extreme predispositions for the development of hypertension
Tokudome et al., Metabolism 2004 : In cardiac myocytes, high glucose had no effect, but insulin increased protein synthesis and atrial natriuretic peptide (ANP) secretion and gene expression
Bai et al., Peptides 2006 (Diabetes Mellitus) : Augmentation of insulin stimulated ANP release through tyrosine kinase and PI 3-kinase in diabetic rats ... The aim of present study was to define the effects of insulin on atrial dynamics and ANP release and its modification in diabetic rats ... Insulin increased the release of ANP and decreased atrial contractility in a dose dependent manner ... Wortmannin ( 10 ( -7 ) M ) or LY294002 ( 10 ( -5 ) M ), a PI 3-kinase inhibitor, also attenuated insulin stimulated ANP release ... Insulin stimulated ANP release was augmented in streptozotocin treated rat atria ... These results suggest that insulin stimulates the release of ANP through PI 3-kinase and tyrosine kinase, and augmentation of insulin stimulated ANP release in diabetic rat atria may be partly due to an upregulation of insulin receptor
Birkenfeld et al., J Clin Endocrinol Metab 2006 : Venous glucose and insulin concentrations increased with ANP , both without or with propranolol
Monti et al., Nutr Metab Cardiovasc Dis 2012 (Diabetes Mellitus, Type 2...) : In MVD, left atrial ( LA ) volume, ANP, FFA incremental area and insulin levels were higher and Insulin Sensitivity (IS) index significantly reduced while after surgery, LA volume, ANP and FFA significantly decreased and IS index significantly improved
You et al., Am J Physiol Endocrinol Metab 2011 : Atrial natriuretic peptide (ANP) levels correlate with hyperglycemia in diabetes mellitus, but ANP effects on pancreatic islet ß-cell insulin secretion are controversial ... However, the combination of potassium chloride and a-ketoisocaproic acid was sufficient to overcome the inhibitory effects of ANP on insulin secretion
Kokot et al., Kardiol Pol 1990 : A significant correlation was found between WI induced increase of blood insulin and ANP and between the increase of ANP and decline of blood glucose both in HTP and in healthy subjects
Verspohl et al., Naunyn Schmiedebergs Arch Pharmacol 1989 : ANP was able to augment cGMP levels in islets, but was not able to enhance insulin secretion at various glucose concentrations ... Therefore, the recently observed in vivo elevation of plasma insulin levels in response to ANP is rather an indirect than a direct effect