Gene interactions and pathways from curated databases and text-mining

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INS — NPS

Text-mined interactions from Literome

Ahrén et al., Ann Acad Med Singapore 1999 : Regulation of insulin secretion by nerves and neuropeptides
Colombo et al., Pancreas 2003 : Effects of ghrelin and other neuropeptides ( CART, MCH, orexin A and B, and GLP-1 ) on the release of insulin from isolated rat islets
Mühlhäusler et al., J Physiol 2005 : These findings demonstrate that increased circulating glucose and insulin regulate gene expression of the neuropeptides within the fetal hypothalamus that are part of the neural network regulating energy balance in adult life
Ahrén et al., Nutr Metab Cardiovasc Dis 2006 : This study examined whether the neuropeptides , pituitary adenylate cyclase activating polypeptide ( PACAP ) and gastrin releasing polypeptide (GRP) contribute to the regulation of insulin secretion in model experiments by using receptor gene deleted mice
Persson-Sjögren et al., Neuropeptides 2006 : The neuropeptides increased insulin release in islets from 9 to 10-month-old mice but VIP and PACAP had no effect in islets from very old mice
O'Carroll et al., J Endocrinol 2008 : Both neuropeptides stimulated insulin secretion from isolated mouse pancreatic islets
Warne et al., J Neuroendocrinol 2008 (Diabetes Mellitus, Experimental) : Because hypothalamic and limbic mRNA expression of neuropeptides linked to energy balance is altered by STZ-diabetes and HV, we examined the role ( s ) of insulin and the common hepatic and gastroduodenal branches of the vagus nerve and hepatic afferent fibres in the regulation of these neuropeptides in rats with high, steady-state corticosterone levels
Gurevitch et al., Nanotoxicology 2012 (Insulin Resistance) : We hypothesized that despite being considered `` inert '' as bulk material, TiO ( 2 ) NPs may impair insulin responses in liver derived cells, either indirectly by inflammatory activation of macrophages, and/or by directly interfering with insulin signaling
Reimer et al., J Nutr 2012 (Diabetes Mellitus, Type 2...) : Insulin secretion and ß-cell mass was increased with NPS ( P < 0.05 )
Schnuerer et al., Regul Pept 1987 : The results suggest a possible modulatory role for these neuropeptides in regulation of insulin secretion
Sipols et al., Diabetes 1995 (Diabetes Mellitus, Experimental...) : To evaluate whether central nervous system ( CNS ) insulin deficiency affects expression of neuropeptides involved in food intake, in situ hybridization was done for neuropeptide Y (NPY), which stimulates feeding, in the hypothalamic arcuate nucleus and for cholecystokinin (CCK) and corticotropin releasing hormone (CRH), which inhibit feeding, in the hypothalamic paraventricular nucleus