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BMP7 — CHRD

Pathways - manually collected, often from reviews:

• BioCarta alk in cardiac myocytes: BMP/BMPR-II/ALK3 complex (BMPR2-BMPR1A-BMP7_BMP2_BMP5_BMP10_BMP4) → CHORDIN (CHRD) (modification, activates)
• KEGG TGF-beta signaling pathway: CHRD → AMH/BMP2/BMP4/BMP5/BMP6/BMP7/BMP8A/BMP8B/GDF5/GDF6/GDF7 (protein-protein, inhibition)
  

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• STRING interaction: BMP7 — CHRD (interaction, mapped from kegg_pathways)
• STRING interaction: CHRD — BMP7 (interaction, mapped from kegg_pathways)

Text-mined interactions from Literome

Connors et al., Development 1999 (Limb Deformities, Congenital) : At this time, unimpeded Chordin may diffuse to the most ventral marginal regions and inhibit high Bmp activity levels
Blitz et al., Dev Biol 2000 : We examine the possibility that chordin , a secreted inhibitor of bone morphogenetic protein ( BMP ) signaling and candidate `` dorsalizing signal, '' is a long-range acting factor
Darras et al., Dev Biol 2001 : ( 3 ) At the tailbud stage, among these pigment cell precursors, BMPb induces the differentiation of specifically the anterior type of pigment cell, the otolith ; while posteriorly, CHORDIN suppresses BMP activity and allows ocellus differentiation
Wagner et al., Dev Biol 2002 : As has been proposed for the fly orthologue of chordin, short gastrulation, our paradoxical results can be explained by a model whereby Chordin both antagonizes and promotes BMP activity
Quint et al., Proc Natl Acad Sci U S A 2002 : The effects of shh ectopic expression could be antagonized by ectopic expression of chordin , an inhibitor of bone morphogenetic protein ( bmp ) signaling
Jasuja et al., J Biol Chem 2004 : The secreted protein Twisted Gastrulation ( TSG ) is thought to help shape BMP signaling gradients by acting as a cofactor that enhances Chordin inhibition of BMP signaling
Moll et al., FASEB J 2006 (Neoplasm Invasiveness...) : We previously reported the expression of human chordin (CHRD) , a BMP extracellular regulator , in the ovary
Olivares et al., Dev Biol 2009 : Overexpression of Xenopus Syn1 ( xSyn1 ) mRNA is sufficient to reduce BMP signaling, induce chordin expression and rescue dorso-ventral patterning in ventralized embryos
Soofi et al., J Am Soc Nephrol 2013 (Acute Kidney Injury...) : The secreted kielin/chordin-like ( KCP ) protein, one of a family of cysteine-rich proteins, suppresses TGF-ß signaling by sequestering the ligand from its receptor, but it enhances bone morphogenetic protein ( BMP ) signaling by promoting ligand-receptor interactions
Streit et al., Development 1998 : These results suggest that the regulation of BMP signalling by chordin plays a role in primitive streak formation and that chordin is not sufficient to induce neural tissue