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FASLG — MYC
Text-mined interactions from Literome
Brunner et al., J Biol Chem 2000
:
Expression of
Fas ligand in activated T cells is
regulated by
c-Myc
Kasibhatla et al., Curr Biol 2000
:
A ` non-canonical ' DNA binding element mediates the
response of the
Fas-ligand promoter to
c-Myc ... The FasL promoter can be driven by
c-Myc overexpression, and functional inhibitors of Myc and its binding partner, Max,
inhibit the transcriptional activity of the
FasL promoter [ 9,10 ]
Tani et al., FEBS Lett 2001
(Brain Neoplasms...) :
Proteasome inhibitors induce Fas mediated apoptosis by
c-Myc accumulation and subsequent
induction of
FasL message in human glioma cells
Wiener et al., Exp Cell Res 2004
(Carcinoma, Non-Small-Cell Lung...) :
Our results revealed that inhibition of c-Myc/Max did not substantially reduce basal levels of
Fas ligand promoter activity, nor did overexpression of
c-Myc significantly
induce promoter activity ... Our results revealed that inhibition of
c-Myc/Max did not substantially
reduce basal levels of
Fas ligand promoter activity, nor did overexpression of c-Myc significantly induce promoter activity
Duan et al., Dig Dis Sci 2010
(Bile Duct Neoplasms...) :
The
effects of MAPK-ERK cascade inhibitor and
c-Myc inhibition by siRNA on 67-kDa laminin receptor induced
FasL expression were determined
Wang et al., Oncogene 1998
:
Thus,
c-Myc plays a fundamental role in the regulation of the expression of
FasL , but not Fas and IL-2