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APOB — IGF1
Text-mined interactions from Literome
Scheidegger et al., J Biol Chem 2000
:
In addition, native and oxidized
LDL significantly
increased IGF-1 binding protein-2 and
IGF-1 binding protein-4 expression as measured by Western ligand blot
Li et al., Arterioscler Thromb Vasc Biol 2003
:
We have shown previously that oxidized
LDL decreases insulin-like growth factor-1 (IGF-1) and IGF-1 receptor expression in vascular smooth muscle cells and that
IGF-1 and IGF-1 receptor expression are
reduced in the deep intima of early atherosclerotic lesions
Ostlund et al., Mol Endocrinol 1994
:
IGF-I increased
LDL receptors in cultured human skin fibroblasts at concentrations greater than 25 ng/ml
Kauf et al., Med Klin (Munich) 1995
(Cystic Fibrosis) :
After three months of this therapy we have seen positive metabolic ( normalized content of plasma-selenium, -glutathione peroxidase ), endocrine ( enhanced efficacy of thyroid hormones, mild increased
IgF-I reduced
LDL-chol ) and clinical consequences ( enhanced left ventricular cardiac output ), but in three patients side effects ( anorexia, nausea, mild hair loss ) were observed
Rudling et al., J Clin Invest 1996
:
This investigation was undertaken to evaluate if these effects of GH on hepatic
LDL receptors are direct or
mediated by
insulin-like growth factor I (IGF-I)
Hochberg et al., Eur J Clin Invest 1997
(Turner Syndrome) :
IGF-I stimulated
LDL degradation by 42 +/- 8 % in the control subjects and by only 16 +/- 7 % in Turner 's syndrome patients ( P < 0.05 )