◀ Back to IRF1
IRF1 — IRF7
Pathways - manually collected, often from reviews:
-
BioCarta the information processing pathway at the ifn beta enhancer:
IFN-beta nucleosome complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF-CREBBP-SMARCA4-SMARCD1-ARID1A-SMARCC1-SMARCC2-SMARCB1-SMARCE1-ACTB)
→
RELA/p50/ATF-2/IRF/c-JUN/HMG1/PCAF/CBP/hSWI/SNF complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF-CREBBP-SMARCA4-SMARCD1-ARID1A-SMARCC1-SMARCC2-SMARCB1-SMARCE1-ACTB)
(modification, collaborate)
-
BioCarta the information processing pathway at the ifn beta enhancer:
RELA/p50/ATF-2/IRF/c-JUN/HMG1 complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1)
→
IRF (IRF5/IRF1/IRF3/IRF6/IRF7/IRF4/IRF2)
(modification, collaborate)
-
BioCarta the information processing pathway at the ifn beta enhancer:
RELA/p50/ATF-2/IRF/c-JUN/HMG1 complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1)
→
RELA/p50/ATF-2/IRF/c-JUN/HMG1/PCAF complex (ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF)
(modification, collaborate)
-
BioCarta the information processing pathway at the ifn beta enhancer:
RELA/p50/ATF-2/IRF/c-JUN/HMG1/PCAF/CBP complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF-CREBBP)
→
RELA/p50/ATF-2/IRF/c-JUN/HMG1/PCAF complex (ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF)
(modification, collaborate)
-
BioCarta the information processing pathway at the ifn beta enhancer:
RELA/p50/ATF-2/IRF/c-JUN/HMG1/PCAF/CBP complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF-CREBBP)
→
RELA/p50/ATF-2/IRF/c-JUN/HMG1/PCAF/CBP/hSWI/SNF complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF-CREBBP-SMARCA4-SMARCD1-ARID1A-SMARCC1-SMARCC2-SMARCB1-SMARCE1-ACTB)
(modification, collaborate)
-
FastForward regulation:
IRF1
→
IRF7
(transcriptional regulation, unknown)
Lu et al., J Biol Chem 2000*
Evidence: PROMACTIVITY, DNABINDING
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Xi et al., Oncogene 1999
(Pancreatic Neoplasms) :
Here we report that the human CIITA Type IV promoter
IRF-E binds IRF-1 and can be
activated by exogenous expression of
IRF-1
Xi et al., Mol Immunol 2003
:
Off-rate experiments revealed that the
IRF-2/IRF-E complex was more stable than the IRF-1/IRF-E complex and that the affinity of
IRF-1 for the IRF-E was
increased when IRF-1 co-occupied the IRF-E with IRF-2
Guo et al., J Immunol 2005
:
IRF-2 constitutively binds to the two ISRE/IRF-E sites at the DRR, while
IRF-1 and STAT1 are
induced to bind to the two
ISRE/IRF-E sites and the ISRE/IRF-E1, respectively, only after IFN-beta treatment
Pan et al., Zhongguo Shi Yan Xue Ye Xue Za Zhi 2010
(Leukemia, Promyelocytic, Acute) :
It is concluded that during ATRA induced APL cell differentiation,
IRF-1 is first upregulated by ATRA, and then
IRF-1 increases the protein levels of IRF-9 and STAT2 with the downregulation of C/EBPalpha
Kondo et al., Hokkaido Igaku Zasshi 1996
(Leukemia...) :
Functional analysis showed that
IRF-BP inhibited DNA binding and transcriptional activity of
IRF-1