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IRF6 — PGD

Text-mined interactions from Literome

Sato et al., Prostaglandins Leukot Essent Fatty Acids 2006 : At all concentrations tested, LPS significantly enhanced PGD2 production by human choriodecidual explants compared to PGE2 and PGF2alpha production
Gao et al., J Physiol Pharmacol 2009 (Fever) : Interestingly, pretreatment with a novel selective inhibitor of hematopoietic prostaglandin D synthase ( H-PGDS ), EDJ300520 ( 10-40 mg/kg p.o. ), selectively and dose-dependently prevented the LPS induced increase of PGD ( 2 ) in plasma and lungs but did not affect the PGE ( 2 ) content
Shimura et al., Am J Pathol 2010 : Lipopolysaccharide (LPS) reduced H-PGDS expression, but interferon-gamma followed by LPS induced significant PGD2 production in a delayed time course at 6 hours
Sun et al., Int Immunopharmacol 2011 (Hemolysis...) : PD, PD2, PA, and PGD significantly not only promoted concanavalin A ( Con A ) -, lipopolysaccharide (LPS)- and antigen induced splenocyte proliferation, but enhanced the NK cell activity in mice immunized with rL-H5
Zhao et al., Mol Pharmacol 2013 : We observed that pretreatment of BMDM with two structurally unrelated ROS scavengers, MnTMPyP and EUK-134, not only prevented LPS induced ROS accumulation, but also attenuated the LPS induced PGD ( 2 ), but not PGE ( 2 ), production ... Conversely LPS induced PGD ( 2 ), but not PGE ( 2 ), production, was potentiated with the cotreatment of BMDM with H ( 2 ) O ( 2 ) ... In addition, selective inhibition of the ROS generator NADPH oxidase ( NOX ) using either pharmacologic inhibitors or its p47(phox) subunit deficient mouse BMDM also attenuated LPS induced PGD ( 2 ), but not PGE ( 2 ) production, suggesting the critical role of NOX generated ROS in LPS induced PGD ( 2 ) production in BMDM ... We further found that both hematopoietic PGD synthase (H-PGDS) siRNA and its inhibitor HQL-79, but not lipocalin PGDS ( L-PGDS ) siRNA and its inhibitor AT-56, significantly attenuated LPS induced PGD ( 2 ) production, suggesting that H-PGDS, but not L-PGDS, mediates LPS induced PGD ( 2 ) production in BMDM
Xiao et al., PloS one 2012 : Our data show that LPS induced both PGE ( 2 ) and PGD ( 2 ) production, which was evident by ~8 hrs and remained at a similar ratio ( ~1:1 ) in the early phase ( =12 hrs ) of LPS treatment
Lu et al., Food Chem Toxicol 2013 : HEE suppressed SCF/IL-10/LPS induced PGD2 generation, and concomitantly reduced COX-2 protein expression dose-dependently
Yamamoto et al., Biochem Biophys Res Commun 1988 : A large amount of PGD2 was released into the culture medium by stimulation with MDP, LPS , and IL-1 but DSIP and uridine failed to stimulate such release
Longo et al., Prostaglandins Other Lipid Mediat 1998 : Only Ca Ion stimulated prostaglandin D2 (PGD2) production while IL-1 beta, and Ca Ion, but not LPS , increased prostaglandin F2 alpha ( PGF2 alpha ) formation