Mühl et al., FEBS Lett 1991
:
PDGF-BB dose-dependently suppressed the IL-1 beta- and forskolin induced elevation of PLA2 mRNA, as well as PLA2 synthesis and secretion ... The tyrosine kinase inhibitor genistein dose-dependently antagonized the inhibitory effect of PDGF-BB on IL-1 beta stimulated PLA2 secretion, thus suggesting that tyrosine phosphorylation may be required for PDGF-BB inhibition of PLA2 gene expression in mesangial cells
Walker et al., Biochim Biophys Acta 1998
:
Platelet derived growth factor (PDGF)-BB potently inhibits secretion of IL-1beta- and forskolin induced group II PLA2 activity