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EPHB2 — PRL

Text-mined interactions from Literome

Gubbay et al., J Clin Endocrinol Metab 2002 : Prolactin induces ERK phosphorylation in epithelial and CD56 ( + ) natural killer cells of the human endometrium ... Using immunofluorescence histochemistry, PRL induced phosphorylation of ERK in the stromal compartment was localized to the uterine-specific CD56 ( + ) natural killer ( NK ) cells ... We have further demonstrated phosphorylation of ERK 1 and 2 in cultures of purified uterine CD56 ( + ) NK cells, in response to PRL
Carpenter et al., Endocrinology 2003 (Hyperprolactinemia) : In study four, Western blot analyses indicated that PRL increased levels of phosphorylated STATs 1 and 5, but not STAT 3, and phosphorylated ERK 1 and 2 MAPKs and c-Jun N-terminal kinase/stress activated protein kinase proteins in explanted PND 28 ovine uteri
Amaral et al., Horm Metab Res 2003 : PRL also induced JAK2, SHC, ERK1 and ERK2 phosphorylation in neonatal islets, demonstrating that PRL can activate MAPK
Gutzman et al., Mol Endocrinol 2005 (Breast Neoplasms...) : In addition to the acute PRL induced ERK1/2 activation, PRL and E2 also individually elicited delayed, sustained rises in levels of phosphorylated p38 and especially ERK1/2
Huang et al., Oncogene 2006 (Breast Neoplasms) : Our data suggest that PRL synergistically augments EGF signaling in T47D breast cancer cells at least in part by lessening EGF induced EGFR downregulation and that this effect requires PRL induced ERK activity and threonine phosphorylation of EGFR
Ueda et al., Endocrinology 2006 : Because S179D PRL and basic fibroblast growth factor (bFGF) have both been shown to activate ERK , the effect of S179D PRL on bFGF induced ERK signaling was examined ... S179D PRL blocked ERK phosphorylation in response to bFGF, whereas continued coincubation caused a delayed and prolonged activation of ERK ... We conclude that S179D PRL blocks bFGF induced ERK signaling and yet uses ERK in a different time frame to elevate p21 and activate the extrinsic pathway
Kanda et al., Endocrinology 2007 (MAP Kinase Signaling System...) : Prolactin induced phosphorylation of JAK2 and ERK , whereas IFN-gamma induced phosphorylation of JAK1, JAK2, and p38 MAPK
Neilson et al., Mol Endocrinol 2007 (Breast Neoplasms) : Finally, suppression of Jak1 by lentiviral delivery of Jak1 short hairpin RNA blocked PRL activation of ERK and signal transducer and activator of transcription ( Stat ) 3 and suppressed PRL activation of Jak2, Stat5a, Stat5b, and Akt, as well as tyrosine phosphorylation of PRLR
Tipsmark et al., J Endocrinol 2008 : We therefore tested whether ERK1/2 might be involved in the leptin PRL response and found that the ERK inhibitor, PD98059, hindered leptin induced PRL release
Blume et al., Endocrinology 2009 : PRL also induced ERK phosphorylation in vitro in the hypothalamic cell line, 4B, which expresses PRL receptors, and in primary hypothalamic neuronal cultures
Wagner et al., Cell Physiol Biochem 2009 (MAP Kinase Signaling System) : Even though we could demonstrate that NPCs express the PRL receptor and ERK1/2 signaling is induced by PRL , we did not observe any effect of PRL on NPCs proliferation, differentiation or survival, neither in the presence nor during absence of DEX
Galbaugh et al., Mol Cancer Res 2010 (Breast Neoplasms) : In contrast, overexpression of SIRPa in the presence of collagen 1 increased PRL induced gene expression ; phosphorylation of Jak2, Stat5, and Erk ; and PRL stimulated cell growth
Pertuit et al., Endocrinology 2011 : The gsp oncogene disrupts Ras/ERK dependent prolactin gene regulation in gsp inducible somatotroph cell line
Reuwer et al., J Cell Mol Med 2012 (Breast Neoplasms...) : In the present study, we show that prolactin induces phosphorylation of ERK1/2 and STAT5 and induces tube formation of endothelial cells on Matrigel