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CBX3 — PTGS2

Text-mined interactions from Literome

Young et al., Endocrinology 2003 (Cardiomegaly...) : Both DOC and CBX increased systolic blood pressure, heart, and kidney weight, and expression of cyclooxygenase 2 , ED-1 positive macrophages, and osteopontin, with effects of both DOC and CBX blocked by the selective MR antagonist eplerenone
Yang et al., Anticancer Drugs 2004 : Since many tumor cells exhibit COX-2 expression, functional imaging of COX-2 expression using celebrex ( CBX , a COX-2 inhibitor ) may provide not only a non-invasive, reproducible, quantifiable alternative to biopsies, but it also greatly complements pharmacokinetic studies by correlating clinical responses with biological effects
Alvarez-Soria et al., Osteoarthritis Cartilage 2008 (Osteoarthritis, Knee) : Both CBX and ACF inhibited COX-2 , microsomal prostaglandin E synthase-1 ( mPGES-1 ) and inducible nitric oxide synthase (iNOS) synthesis in the articular cartilage of OA patients