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CRP — FCGR1A

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: FCGR1A → CRP (increases, CRP Activity) Han et al., Circulation 2004*
  Evidence: The CRP-induced upregulation of CCR2 expression involved binding of CRP to the FcgammaR, most notably FcgammaRI, and phospholipase D1 activation.

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Hprd Interaction: CRP — FCGR1A (in vivo) Mold et al., J Immunol 2002*
• IRef Ophid Interaction: CRP — FCGR1A (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• IRef Ophid Interaction: CRP — FCGR1A (aggregation, confirmational text mining) Mold et al., J Immunol 2002*

Text-mined interactions from Literome

Bodman-Smith et al., Immunology 2002 : These studies indicate that CRP is capable of binding to and cross linking FcgammaRI thereby resulting in PLD activation and increased phagocytosis
Bodman-Smith et al., J Leukoc Biol 2004 : FcgammaRIIa expression with FcgammaRI results in C-reactive protein- and IgG mediated phagocytosis
Montecucco et al., J Leukoc Biol 2008 : Stimulation with CRP induced release of CCL2, CCL3, and CCL4 in adherent monocytes through the binding to CD32a, CD32b, and CD64 , whereas no effect was observed in suspension culture
Devaraj et al., J Leukoc Biol 2009 : Antibodies to CD32 and CD64 but not CD16 abrogated CRP induced M-CSF release