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ATR — RELA
Pathways - manually collected, often from reviews:
-
BioCarta atm signaling pathway:
ATR/ATRIP/ATM complex (ATR-TREX1-ATM)
→
NF-kappa-B/I-kappa-B-alpha complex (NFKBIA-RELA)
(protein ubiquitination, activates)
-
BioCarta atm signaling pathway:
ATR/ATRIP/ATM complex (ATR-TREX1-ATM)
→
I-kappa-B-alpha/RELA/p50/ubiquitin complex (NFKBIA-RELA)
(protein ubiquitination, activates)
Text-mined interactions from Literome
Campbell et al., Cancer Res 2006
(Bone Neoplasms...) :
The mechanism through which cisplatin achieves these effects is different to daunorubicin and UV light but shows great similarity to the RelA regulatory pathway induced by the ARF tumor suppressor : cisplatin regulation of
RelA requires
ATR/Chk1 activity, represses Bcl-x ( L ) but not XIAP expression, and results in phosphorylation of RelA at Thr ( 505 )
Ravi et al., Mol Cell Biochem 2008
(Melanoma) :
In addition, our study shows that ATM, but not
ATM-Rad3 related (ATR) or DNA dependent protein kinase (DNA-PK) is
involved in UV-induced
NF-kappaB activation
Wu et al., EMBO J 2008
:
Consequently,
ATR represses
NF-kappaB activation induced by replication stress ... Reduction or increase of
ATR expression by RNA interference or overexpression increased or
reduced ATM-NEMO association and
NF-kappaB activation induced by HU