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GP2 — RELA
Text-mined interactions from Literome
D'Addario et al., J Mol Biol 2001
:
To our knowledge this is the first report showing that the binding of a herpesvirus envelope
glycoprotein to CR2 on human B cells
results in the activation of the
NF-kappaB transcription factor leading to the upregulation of IL-6 gene expression in these lymphocytes
Bentires-Alj et al., Oncogene 2003
(Colonic Neoplasms) :
Indeed, the inhibition of
NF-kappaB reduced mdr1 mRNA and
P-glycoprotein expression in HCT15 cells
Lee et al., Cancer Chemother Pharmacol 2004
:
As expected, SNL
glycoprotein dose-dependently
inhibited PKCalpha translocation,
NF-kappaB DNA binding activity, NF-kappaB protein activity and NO production in HCT-116 cells stimulated with TPA ( 61.68 ng/ml, 100 nM )
Heo et al., Toxicol In Vitro 2004
(Breast Neoplasms) :
To test the
effect of SNL
glycoprotein on the DNA binding activities of
nuclear factor-kappa B (NF-kappaB) and activator protein-1 (AP-1), and nitric oxide ( NO ) production, these experiments were carried out using electrophoretic mobility shift assays ( EMSA ), western blot analysis, and the Griess method ... Results in this experiment showed that SNL
glycoprotein inhibits 12-O-Tetra decanoylphorbol-13-acetate ( TPA ; 100 nM ) -induced DNA binding activities of
NF-kappaB and AP-1, and enhances NO production in MCF-7 cells
Ko et al., Toxicol In Vitro 2005
:
We also demonstrated that RVS
glycoprotein inhibits activities of the
nuclear factor-kappa B (NF-kappaB) and activator protein-1 (AP-1) induced by G/GO, and prevents from G/GO induced apoptosis in the NIH/3T3 cells
Heo et al., J Med Food 2005
:
The results in this study indicated that SNL
glycoprotein induces apoptosis through modulation of PKCalpha and
NF-kappaB activity in MCF-7 cells ... In fact, SNL
glycoprotein interfered with PKCalpha membrane translocation and
inhibited NF-kappaB ( p50 ) protein activity in MCF-7 cells stimulated with TPA ( 61.68 ng/mL, 100 nM ) dose-dependently
Lim et al., J Med Food 2005
:
Taken together, the results of this study showed that the
activation of PKCalpha,
NF-kappaB , and Bax expression by SNL
glycoprotein is possibly involved in the apoptotic process
Deepak et al., Biochimie 2006
(Carcinoma, Ehrlich Tumor...) :
Antiangiogenic and proapoptotic activity of a novel
glycoprotein from U. indica is
mediated by
NF-kappaB and Caspase activated DNase in ascites tumor model
Lee et al., Food Chem Toxicol 2007
(Colitis) :
In addition, the results obtained from electrophoretic mobility shift assay ( EMSA ) and western blot analysis showed that UDN
glycoprotein dose-dependently
inhibits DNA binding activity of
nuclear factor-kappa B (NF-kappaB) , and activities of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and manganese-superoxide dismutases ( Mn-SOD ) in LPS stimulated RAW 264.7 cells
Lee et al., Cancer Lett 2007
(Colonic Neoplasms) :
The results obtained from electrophoretic mobility shift assay ( EMSA ) and Western blot analysis showed that UDN
glycoprotein blocks the DNA binding activities of
nuclear factor-kappaB (NF-kappaB) and activator protein-1 (AP-1), and attenuates the activities of NF-kappaB subunits ( p50 and p65 ), and AP-1 subunits ( c-Jun and c-Fos ), respectively
Lee et al., J Nutr Biochem 2008
(Carcinoma, Hepatocellular...) :
In nuclear factor-kappa B (NF-kappaB) mediated apoptosis pathway, the results showed that SNL
glycoprotein dose-dependently
blocked DNA binding activity of
NF-kappaB , activity of inducible nitric oxide synthase (iNOS) and production of inducible nitric oxide ( NO )
Lee et al., Toxicol Appl Pharmacol 2007
(Colonic Neoplasms...) :
Also, 0.02 % UDN
glycoprotein suppressed the DNA binding activities of
nuclear factor-kappa B (NF-kappaB) and activator protein-1 (AP-1), accompanying the inhibitions of its subunits ( p50, p65, c-Jun, and c-Fos ), pro-inflammatory proteins [ inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2) ], and pro-inflammatory cytokines [ tumor necrosis factor (TNF)-alpha and interleukin (IL)-6 ] on DMH stimulated ACF formation
Hartz et al., FASEB J 2008
:
Inhibition of JNK, but not
NF-kappaB ,
blocked DEP induced
P-glycoprotein up-regulation, indicating a role for AP-1 in the signaling pathway
Yurochko et al., J Virol 1997
:
The human cytomegalovirus UL55 ( gB ) and UL75 ( gH )
glycoprotein ligands
initiate the rapid activation of Sp1 and
NF-kappaB during infection
Mejdoubi et al., Biochem Biophys Res Commun 1999
:
NF-kappaB is
involved in the induction of the rat hepatic alpha1-acid
glycoprotein gene by phenobarbital