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MMP2 — RELA
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Mengshol et al., Arthritis Rheum 2000
(MAP Kinase Signaling System) :
In chondrosarcoma cells,
MMP-1 induction depends on p38 and MEK ( an MAPK kinase of the extracellular signal regulated kinase pathway ) and does not
require JNK or
NF-kappaB
Philip et al., J Biol Chem 2003
:
We also investigated the mechanism of action of curcumin ( diferulolylmethane ) on OPN induced
NF kappa B-mediated activation of
pro-MMP-2 in B16F10 cells
Shukla et al., Neoplasia (New York, N.Y.) 2004
(Adenocarcinoma...) :
The nuclear levels of NF-kappaB/p65 correlated with concurrent increase in cytosolic levels of IkappaBalpha along with
NF-kappaB dependent expression of Bcl2, cyclin D1,
MMP-9 , and VEGF
Xie et al., J Biol Chem 2004
:
These observations suggest that 1 ) activation of ERK1/2 and JNKs plays a critical role in the regulation of MMP-9, not MMP-2, expression and activity ; 2 ) PKC-alpha/beta1 act upstream of JNKs, not ERK1/2 ; 3 ) PKC-zeta and -theta, not PKC-epsilon, act upstream of JNKs, ERK1/2, and NF-kappaB ; and 4 ) activation of
NF-kappaB stimulates expression and activity of
MMP-2 and -9
Dai et al., Ann Rheum Dis 2005
(Arthritis...) :
In chondrocytes responding to IL18, IL18 ( 1-100 ng/ml ) slightly increased the production of MMP-1,
MMP-3 , and MMP-13, which was
blocked by
NF-kappaB inhibitor and p38 mitogen activated protein kinase inhibitor
Lee et al., Virology 2005
:
Moreover,
NF-kappaB dependent expression of
matrix metalloproteinase (MMP)-2 and MMP-9 was observed in PRRSV infected cells, an observation which implies that NF-kappaB activation is a biologically significant aspect of PRRSV pathogenesis
Yoshida et al., Respirology 2006
(Pulmonary Emphysema) :
A specific inhibitor of
NF-kappaB reduced
MMP production by alveolar macrophages from SP-D-/- mice
Fan et al., Rheumatol Int 2006
:
Role of mitogen activated protein kinases and
NFkappaB on IL-1beta induced effects on collagen type II,
MMP-1 and 13 mRNA expression in normal articular human chondrocytes
Bachmeier et al., Cell Physiol Biochem 2007
(Breast Neoplasms...) :
68 % of Curcumin treated but only 17 % of untreated animals showed no or very few lung metastases, most likely as a consequence of down-regulation of
NFkappa B/AP-1 dependent
MMP expression and direct apoptotic effects on circulating tumor cells but not on established metastases
Geraghty et al., J Immunol 2007
(Pseudomonas Infections) :
We also demonstrate that NE can activate NF-kappaB in macrophages, and inhibition of
NF-kappaB resulted in a reduction of NE-induced cathepsin B and
MMP-2
Caruso et al., J Immunol 2007
(Gastritis...) :
Analysis of signaling pathways leading to MMP production reveals that IL-21 enhances NF-kappaB but not MAPK activation, and inhibition of
NF-kappaB activation
reduces IL-21 induced
MMP-2 and MMP-9 production
Yu et al., Gynecol Oncol 2007
(Lung Neoplasms...) :
As ( 2 ) O ( 3 ) treatment also resulted in a positive regulation of caveolin-1, upregulation of E-cadherin and decreased activity of beta-catenin, NF-kappaB and
NF-kappaB regulated gene
MMP-2
Bogatkevich et al., Arthritis Rheum 2007
(MAP Kinase Signaling System...) :
Inhibition of
MMP activity by MMP inhibitor GM1489 and inhibition of MMP-1 expression by siRNA did not
prevent HGF induced ERK-1/2 phosphorylation and
NF-kappaB activity, but significantly restored HGF inhibited collagen and CTGF accumulation
Adya et al., Diabetes Care 2008
(Diabetes Mellitus, Type 2...) :
Visfatin induced
NF-kappaB signaling in human endothelial cells
affects the activation of gelatinases
MMP-2 and -9, suggesting an important role of visfatin in the pathogenesis of vascular inflammation in obesity and type 2 diabetes
Park et al., Carcinogenesis 2009
(Cell Transformation, Neoplastic...) :
The upregulation of
MMP-2 induced by phosphatidic acid ( PA ), the product of PLD, was
mediated by protein kinase C ( PKC ), protein kinase A (PKA),
nuclear factor-kappaB (NF-kappaB) and Sp1 and it enhanced glioma cell invasion
Wu et al., Cancer Lett 2009
(Carcinoma, Hepatocellular...) :
Inhibition of
NF-kappaB activity significantly reduced proliferation and invasion of Hep3B cells as well as
down-regulated the expression of invasion related molecules including
matrix metalloproteinase (MMP)-2 , MMP-9, membrane type-1 MMP (MT1-MMP), urokinase plasminogen activator (uPA) and vascular endothelial growth factor ( VEGF )
Castier et al., Antioxid Redox Signal 2009
:
Hence, induction of
NF-kappaB by shear stress
contributes to
MMP induction and allows long-term flow induced vascular enlargement
Qi et al., Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2009
:
Curcumin can restrain expression of
MMP-2 and MMP-9 in cystiform tissue of air-pouch animal models, and expression of MMP-2 and MMP-9 may be
regulated by the activation of
NF-kappaB
Shin et al., J Med Food 2009
(Carcinoma, Hepatocellular...) :
They also inhibited expression of
matrix metalloproteinase (MMP)-2 and MMP-9 and
activation of
nuclear factor kappaB (NF-kappaB) stimulated by tumor necrosis factor alpha
Moon et al., Int Immunopharmacol 2010
(Arthritis, Experimental...) :
Additionally, by altering
nuclear factor (NF)-kappaB transcription activity in FLSs, curcumin
inhibited PGE ( 2 ) production, COX-2 expression, and
MMP secretion
Martinez-Orozco et al., Eur J Cell Biol 2010
(Neoplasm Invasiveness) :
We demonstrate here that AA promotes an increase in vimentin and N-cadherin expression,
MMP-9 secretion, a decrease in E-cadherin junctional levels, and the
activation of FAK, Src and
NF-kappaB in MCF10A cells
Liu et al., Cancer Lett 2010
(Prostatic Neoplasms) :
In this study, we investigated the roles of OPN in human prostate cancer cells and provided clues about the possible functions of IkappaB kinase (IKK) in
NF-kappaB mediated OPN induced activations of
MMP-2 and MMP-9
Liu et al., Mol Nutr Food Res 2010
(Adenocarcinoma...) :
Nuclear factor (NF)-kappaB inhibitor
induced a marked reduction in MMP-9 and
MMP-2 expression, suggesting NF-kappaB pathway could play an important role
Ho et al., Food Chem Toxicol 2010
(Adenocarcinoma...) :
It is possible that the suppressive effect of GA on
MMP-2/9 might
involve the inhibition of
NF-kappaB activity
Chen et al., Exp Lung Res 2013
(Carcinoma, Non-Small-Cell Lung...) :
In addition, we found that the knockdown of NUAK1 suppressed the expression of
MMP-2 and MMP-9 and the
activation of
NF-kB , which can regulate the transcription of MMP-2 and MMP-9
Yang et al., Eur Rev Med Pharmacol Sci 2013
(Kidney Neoplasms...) :
RNA interference suppression of A100A4 reduces the growth and metastatic phenotype of human renal cancer cells via
NF-kB dependent
MMP-2 and bcl-2 pathway