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IFNB1 — IL2
Text-mined interactions from Literome
Lou et al., Lab Invest 1999
(Multiple Sclerosis) :
Furthermore
IFN-beta did not modulate the expression of adhesion molecules on either stimulated leukocytes or activated HB-MVEC, but partially
reduced TNF and
interleukin-1 production from stimulated leukocytes during coculture with HB-MVEC
Yao et al., J Interferon Cytokine Res 2001
:
Regulation by
IFN-beta of inducible nitric oxide synthase and
interleukin-12/p40 in murine macrophages cultured in the presence of Chlamydia pneumoniae antigens
Dalod et al., J Exp Med 2002
:
Interferon alpha/beta and
interleukin 12
responses to viral infections : pathways regulating dendritic cell cytokine expression in vivo
Bahner et al., Neurosci Lett 2002
(Multiple Sclerosis, Chronic Progressive) :
Interferon-beta-1b increases serum
interleukin-12 p40 levels in primary progressive multiple sclerosis patients
Davis et al., J Immunol 2008
:
Cutting edge : a T-bet independent
role for
IFN-alpha/beta in regulating
IL-2 secretion in human CD4+ central memory T cells
Marsh et al., J Neurosci 2009
(Infarction, Middle Cerebral Artery...) :
TLR4 can
induce both
IFNbeta and interferon stimulated genes through its adapter molecule
Toll/interleukin receptor domain containing adaptor inducing IFNbeta ( TRIF ) and the IRF3 transcription factor
Klimpel et al., Cell Immunol 1990
(Virus Diseases) :
IL-2 greatly
enhanced the production of
IFN-alpha/beta by all cell populations in response to NDV
Reyes et al., Cell Immunol 1986
(Graft vs Host Disease) :
In this report we show evidence suggesting that
interleukin 2 (IL-2) may
play a role in this
IFN-alpha/beta production by alloantigen stimulated BM cells ...
IL-2 induced
IFN-alpha/beta production was partially resistant to irradiation ... Thus, neither T cells nor NK cells are required for
IL-2 induced
IFN-alpha/beta production by BM cells ... These results suggest that non-T cells resident in the BM have receptors for IL-2 and can produce
IFN-alpha/beta upon
stimulation by
IL-2
Sehgal et al., Proc Natl Acad Sci U S A 1987
:
The
enhancement of
IFN-beta 2 gene expression by diC8,
interleukin 1, or tumor necrosis factor was not prevented by H8, a preferential inhibitor of cAMP- and cGMP dependent protein kinases, but was blocked by H7, an inhibitor of protein kinase C as well as of cyclic nucleotide dependent protein kinases
Abrams et al., Cell Immunol 1986
(Leukemia, Erythroblastic, Acute) :
Overall, these findings suggest that EC, either untreated or pretreated with IFN-beta or IL-2, significantly lose their lytic capabilities following interaction with K562 while retaining their ability to bind to the TC ;
IFN-beta acts predominantly on pre-NK cells, but not on ECi ; and
IL-2 appears to play an important role in restoring lytic potential to functionally inactive NK cells
Kohase et al., Mol Cell Biol 1987
:
Platelet derived growth factor and
interleukin-1 also
led to the increased expression of
IFN-beta 2
Kita et al., C R Seances Soc Biol Fil 1993
(Disease Models, Animal...) :
After HSV-1 infection, IFN-alpha,
IFN-beta , IFN-gamma, IL-1 beta, IL-4, IL-6 and TNF-alpha mRNA were significantly induced, but
IL-2 , IL-3 and IL-5 mRNA were not
induced
Rep et al., J Neuroimmunol 1996
:
Interestingly,
IFN-beta enhanced secretion of
IL-2 about two-fold and secretion of IL-10 nearly four-fold
Arnason et al., Clin Immunol Immunopathol 1996
(Autoimmune Diseases...) :
IFNbeta1b increases
IL-2 production in vitro but decreases production of IFNgamma, LT, and TNF
Cousens et al., Proc Natl Acad Sci U S A 1997
(Cytomegalovirus Infections...) :
Interferon-alpha/beta inhibition of
interleukin 12 and interferon-gamma production in vitro and endogenously during viral infection
Eloranta et al., Scand J Immunol 1997
:
Priming the DC lines with tumour necrosis factor-alpha,
interleukin-10 (IL-10) or IL-4 did not
affect the
IFN-alpha/beta response induced by HSV
Hunter et al., Immunol Lett 1997
:
In contrast to the stimulatory effect of IFN-alpha/beta on NK cell production of IFN-gamma,
IFN-alpha/beta inhibited
IL-2 induced proliferation of NK cells