Gene interactions and pathways from curated databases and text-mining

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IFNB1 — IL2

Text-mined interactions from Literome

Lou et al., Lab Invest 1999 (Multiple Sclerosis) : Furthermore IFN-beta did not modulate the expression of adhesion molecules on either stimulated leukocytes or activated HB-MVEC, but partially reduced TNF and interleukin-1 production from stimulated leukocytes during coculture with HB-MVEC
Yao et al., J Interferon Cytokine Res 2001 : Regulation by IFN-beta of inducible nitric oxide synthase and interleukin-12/p40 in murine macrophages cultured in the presence of Chlamydia pneumoniae antigens
Dalod et al., J Exp Med 2002 : Interferon alpha/beta and interleukin 12 responses to viral infections : pathways regulating dendritic cell cytokine expression in vivo
Bahner et al., Neurosci Lett 2002 (Multiple Sclerosis, Chronic Progressive) : Interferon-beta-1b increases serum interleukin-12 p40 levels in primary progressive multiple sclerosis patients
Davis et al., J Immunol 2008 : Cutting edge : a T-bet independent role for IFN-alpha/beta in regulating IL-2 secretion in human CD4+ central memory T cells
Marsh et al., J Neurosci 2009 (Infarction, Middle Cerebral Artery...) : TLR4 can induce both IFNbeta and interferon stimulated genes through its adapter molecule Toll/interleukin receptor domain containing adaptor inducing IFNbeta ( TRIF ) and the IRF3 transcription factor
Klimpel et al., Cell Immunol 1990 (Virus Diseases) : IL-2 greatly enhanced the production of IFN-alpha/beta by all cell populations in response to NDV
Reyes et al., Cell Immunol 1986 (Graft vs Host Disease) : In this report we show evidence suggesting that interleukin 2 (IL-2) may play a role in this IFN-alpha/beta production by alloantigen stimulated BM cells ... IL-2 induced IFN-alpha/beta production was partially resistant to irradiation ... Thus, neither T cells nor NK cells are required for IL-2 induced IFN-alpha/beta production by BM cells ... These results suggest that non-T cells resident in the BM have receptors for IL-2 and can produce IFN-alpha/beta upon stimulation by IL-2
Sehgal et al., Proc Natl Acad Sci U S A 1987 : The enhancement of IFN-beta 2 gene expression by diC8, interleukin 1, or tumor necrosis factor was not prevented by H8, a preferential inhibitor of cAMP- and cGMP dependent protein kinases, but was blocked by H7, an inhibitor of protein kinase C as well as of cyclic nucleotide dependent protein kinases
Abrams et al., Cell Immunol 1986 (Leukemia, Erythroblastic, Acute) : Overall, these findings suggest that EC, either untreated or pretreated with IFN-beta or IL-2, significantly lose their lytic capabilities following interaction with K562 while retaining their ability to bind to the TC ; IFN-beta acts predominantly on pre-NK cells, but not on ECi ; and IL-2 appears to play an important role in restoring lytic potential to functionally inactive NK cells
Kohase et al., Mol Cell Biol 1987 : Platelet derived growth factor and interleukin-1 also led to the increased expression of IFN-beta 2
Kita et al., C R Seances Soc Biol Fil 1993 (Disease Models, Animal...) : After HSV-1 infection, IFN-alpha, IFN-beta , IFN-gamma, IL-1 beta, IL-4, IL-6 and TNF-alpha mRNA were significantly induced, but IL-2 , IL-3 and IL-5 mRNA were not induced
Rep et al., J Neuroimmunol 1996 : Interestingly, IFN-beta enhanced secretion of IL-2 about two-fold and secretion of IL-10 nearly four-fold
Arnason et al., Clin Immunol Immunopathol 1996 (Autoimmune Diseases...) : IFNbeta1b increases IL-2 production in vitro but decreases production of IFNgamma, LT, and TNF
Cousens et al., Proc Natl Acad Sci U S A 1997 (Cytomegalovirus Infections...) : Interferon-alpha/beta inhibition of interleukin 12 and interferon-gamma production in vitro and endogenously during viral infection
Eloranta et al., Scand J Immunol 1997 : Priming the DC lines with tumour necrosis factor-alpha, interleukin-10 (IL-10) or IL-4 did not affect the IFN-alpha/beta response induced by HSV
Hunter et al., Immunol Lett 1997 : In contrast to the stimulatory effect of IFN-alpha/beta on NK cell production of IFN-gamma, IFN-alpha/beta inhibited IL-2 induced proliferation of NK cells