Gene interactions and pathways from curated databases and text-mining

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CAT — IGF1R

Text-mined interactions from Literome

Du et al., Arterioscler Thromb Vasc Biol 1999 : Indeed, catalase abolished the Ang II-stimulated increase of IGF-1R protein expression, and accordingly, H ( 2 ) O ( 2 ) ( 0.2 mmol/L ) or the oxidized products of linoleic acid, hydroperoxyoctadecadienoic acids ( 10 micromol/L ), increased IGF-1R mRNA levels at 3 hours by 74+/-20 % and 107+/-22 % and increased receptor number at 24 hours by 51+/-6.7 % and 55+/-7.4 %, respectively
Higashi et al., J Lipid Res 2005 : However, antioxidants, polyethylene glycol catalase , superoxide dismutase, and Trolox completely blocked OxLDL downregulation of IGF-1R and OxLDL induced apoptosis