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RRM2B — TP53

Pathways - manually collected, often from reviews:

• KEGG p53 signaling pathway: TP53 → RRM2/RRM2B (gene expression, expression)
• WikiPathways miRNA Regulation of DNA Damage Response: TP53 → Complex of GADD45G-GADD45B-SESN1-RRM2B-DDB2-GADD45A (activation)
  
• WikiPathways DNA Damage Response: TP53 → Complex of GADD45G-GADD45B-SESN1-RRM2B-DDB2-GADD45A (activation)
  

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: RRM2B — TP53 (physical association, affinity chromatography technology) Xue et al., Cancer Res 2003*
• IRef Dip Interaction: Complex of RRM2B-ATM-TP53 (anti bait coimmunoprecipitation) Chang et al., Proc Natl Acad Sci U S A 2008
• IRef Dip Interaction: RRM2B — TP53 (physical association, anti tag coimmunoprecipitation) Chang et al., Proc Natl Acad Sci U S A 2008
• IRef Dip Interaction: RRM2B — TP53 (physical association, anti bait coimmunoprecipitation) Chang et al., Proc Natl Acad Sci U S A 2008
• IRef Dip Interaction: RRM2B — TP53 (physical association, fluorescence microscopy) Xue et al., Cancer Res 2003*
• IRef Dip Interaction: RRM2B — TP53 (physical association, coimmunoprecipitation) Xue et al., Cancer Res 2003*
• IRef Hprd Interaction: RRM2B — TP53 (in vivo) Xue et al., Cancer Res 2003*
• IRef Ophid Interaction: RRM2B — TP53 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Tanaka et al., Nature 2000 : Expression of p53R2 , but not R2, was induced by ultraviolet and gamma-irradiation and adriamycin treatment in a wild-type p53 dependent manner
Nakano et al., Oncogene 2000 : p53R2 expression was induced by p53 mutants that are defective for the activation of apoptosis, but retain cell cycle arrest function, although no induction of p53R2 was seen in response to p21 ( WAF1/CIP1 ) -mediated cell cycle arrest
Byun et al., Int J Cancer 2002 (Adenocarcinoma...) : p53R2 is directly induced by wild-type p53 and involved in the p53 checkpoint for repair of damaged DNA, raising the possibility that mutational inactivation of p53R2 may contribute to the development and progression of human malignancies ... Collectively, our study indicates that although p53R2 is induced in a p53 dependent manner and involved the p53 mediated DNA repair in gastric epithelial cells, it is not a critical target of genetic inactivation in gastric tumorigenesis
Patrone et al., J Gen Virol 2003 : Irrespective of UL45 expression, all cellular RR subunits - S-phase RR subunits, and the p53 dependent p53R2 - were induced by infection
Lin et al., J Biol Chem 2004 (Colonic Neoplasms) : The findings provide evidence that R2-RNR can be employed to supply dNTPs for the repair of DNA damage in cells with an impaired p53 dependent induction of p53R2
Uramoto et al., Anticancer Res 2006 (Carcinoma, Non-Small-Cell Lung...) : The expression of p53R2 is induced by DNA damaging agents in a p53 dependent manner and p53R2 translocates to the nucleus upon DNA damage
Nardinocchi et al., Biochem Biophys Res Commun 2007 (Neoplasms) : The failure of p53 induced p53R2 activation markedly compromised damaged-DNA repair efficiency
Pontarin et al., Proc Natl Acad Sci U S A 2008 : p53R2 is induced by p53 after DNA damage and was proposed to supply deoxynucleotides for DNA repair after translocating from the cytosol to the cell nucleus
Link et al., Cancer Res 2008 (Leukemia, Myeloid, Acute...) : In cancer cells, decitabine treatment induces p53R2 mRNA expression, protein expression, and promoter activity in a p53 dependent manner
Li et al., J Biol Chem 2009 : Consequently, MTA1 regulates the p53 dependent transcription of p53R2 , a direct p53 target gene for supplying nucleotides to repair damaged DNA ... Depletion of MTA1 impairs p53 dependent p53R2 transcription and compromises DNA repair
Kang et al., Cell Death Differ 2013 : Under physiological conditions, the antioxidant functions of p53 are mediated by p53R2 , which maintains increased catalase activity and thereby protects against endogenous ROS
Kawakita et al., Osteoarthritis Cartilage 2012 (Osteoarthritis, Knee) : When DNA is damaged, phosphorylation of p53 at its Ser 15 residue induces p53R2 production
Kuo et al., Scientific reports 2012 (Prostatic Neoplasms) : RRM2B suppresses activation of the oxidative stress pathway and is up-regulated by p53 during senescence ... Here, we show that RRM2B is highly induced in a p53 dependent manner during senescence in primary human fibroblast IMR90 cells and is expressed at higher levels in senescent precancerous human prostatic intraepithelial neoplasm lesions compared to adjacent normal prostate glands