Gene interactions and pathways from curated databases and text-mining

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CALM3 — IL2

Text-mined interactions from Literome

Ito et al., J Biol Chem 1991 : These results indicate that calmodulin is required for the interleukin 1-enhanced synthesis of TIMP but it is a suppressor for the synthesis of proMMPs-1 and -3
Sugiyama et al., Clin Exp Immunol 2007 : Because dendritic cells (DCs) orchestrate immune responses, we examined the in vitro effects of clarithromycin (CAM) , azithromycin ( AZM ) and midecamycin ( MDM ) on the expression of co-stimulatory molecules and production of cytokines [interleukin (IL)-10, IL-6, interferon (IFN)-gamma, IL-12p40, tumour necrosis factor (TNF)-alpha ] of murine bone marrow derived DCs by lipopolysaccharide (LPS) stimulation
Yokota et al., Mediators Inflamm 2012 (Respiratory Syncytial Virus Infections) : Clarithromycin (CAM) , which is an antimicrobial agent and is also known as an immunomodulator, significantly suppressed RSV induced production of interleukin-6, interleukin-8 , and regulated on activation, normal T-cell expressed and secreted ( RANTES )
Ojima et al., Biochim Biophys Acta 1989 : Calmodulin regulates the interleukin 1-induced procollagenase production in human uterine cervical fibroblasts
Kawakami et al., Microbiol Immunol 1988 : The IL2 production was reduced by inhibitors of calmodulin and protein kinase C
Hama et al., J Exp Med 1995 : The inhibitory effect of CaM-K II on IL-2 promoter was associated with decreased transcription of its AP-1 and NF-AT transactivating pathways ... When both mutants were used in combination, gamma B*CaM-K inhibited the induction of the IL-2 promoter by delta CaM-AI
Wölfler et al., Life Sci 1998 : Since melatonin has been suggested as a physiological antagonist to calmodulin in certain cell types, we investigated effects of melatonin on calmodulin dependent IL-2 production and proliferation of activated T-lymphocytes