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CTTN — RAC1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Di Ciano et al., Am J Physiol Cell Physiol 2002
:
This appears to be a key event in the osmotically triggered cytoskeletal reorganization, because 1 ) constitutively active small GTPases translocate cortactin, 2 )
Rac and cortactin colocalize at the periphery of hypertonically challenged cells, and 3 ) dominant negative Rac and Cdc42
inhibit the hypertonicity provoked
cortactin and Arp3 translocation
Head et al., Mol Biol Cell 2003
:
Phosphorylation of cortactin tyrosine 421 and 466 was elevated in response to Src, epidermal growth factor receptor and
Rac1 activation , and tyrosine 421 phosphorylated
cortactin localized with F-actin in lamellipodia and podosomes ... These results indicate that cortactin tyrosine phosphorylation requires
Rac1 induced
cortactin targeting to cortical actin networks, where it is tyrosine phosphorylated in hierarchical manner that is closely coordinated with its ability to regulate actin dynamics
El Sayegh et al., Mol Biol Cell 2005
:
We conclude that N-cadherin ligation induces
Rac dependent
cortactin recruitment and Fer dependent cortactin phosphorylation, which in turn promotes enhanced mobilization and interaction of surface expressed N-cadherin in contacting cells
Birukova et al., FASEB J 2007
:
The pharmacological Rac inhibitor or silencing RNA ( siRNA ) based depletion of either
Rac or Tiam1 significantly
attenuated HGF induced peripheral translocation of Rac effector
cortactin , cortical actin ring formation, and EC barrier enhancement
Weed et al., J Cell Sci 1998
:
Translocation of
cortactin to the cell periphery is
mediated by the small GTPase
Rac1 ... In this report we provide evidence that the intracellular localization of the actin binding protein
cortactin , a Src kinase substrate, is
regulated by the activation of
Rac1