Gene interactions and pathways from curated databases and text-mining

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NR3C1 — SRCAP

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: NR3C1 → SRCAP (directlyIncreases, SRCAP Activity) Monroy et al., Mol Endocrinol 2003*
    Evidence: Our current studies demonstrate that SRCAP enhances PEPCK promoter transcription induced by glucocorticoids. SRCAP also enhances GR-mediated transcription of a simple promoter containing only two GRE elements, indicating that SRCAP functions as a GR coactivator.
  • OpenBEL Selventa BEL large corpus: NR3C1 → Complex of NCOA2-SRCAP (directlyIncreases, NCOA2/SRCAP Activity) Monroy et al., Mol Endocrinol 2003*
    Evidence: SRCAP Functions with CARM-1 and GRIP-1 to Synergistically Activate GR-Mediated Transcription