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CDC42 — FGD1

Pathways - manually collected, often from reviews:

• KEGG Regulation of actin cytoskeleton: FGD1/FGD3 → CDC42 (protein-protein, activation)
• NCI Pathway Database Regulation of CDC42 activity: CDC42/GDP complex (CDC42) → FGD1 (FGD1) (modification, collaborate) Zheng et al., J Biol Chem 1996
  Evidence: assay, physical interaction
• Reactome Reaction: FGD1 → CDC42 (reaction) Reid et al., J Biol Chem 1999, Schmidt et al., Genes Dev 2002, Jaffe et al., Annu Rev Cell Dev Biol 2005, Ramos-Morales et al., Oncogene 1995, Pasteris et al., Cell 1994, Hart et al., J Biol Chem 1994, Hart et al., J Biol Chem 1996, Zheng et al., J Biol Chem 1996, Van Aelst et al., Genes Dev 1997, Ren et al., J Biol Chem 1998
• WikiPathways Regulation of Actin Cytoskeleton: FGD1 → CDC42 (activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: FGD1 — CDC42 (direct interaction, pull down) Zheng et al., J Biol Chem 1996
• IRef Hprd Interaction: FGD1 — CDC42 (in vitro) Zheng et al., J Biol Chem 1996
• IRef Ophid Interaction: FGD1 — CDC42 (aggregation, confirmational text mining) Zheng et al., J Biol Chem 1996
• IRef Ophid Interaction: FGD1 — CDC42 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Estrada et al., Hum Mol Genet 2001 (Abnormalities, Multiple) : In contrast, the FYVE-finger and PH2 domains do not appear to direct the localization of Fgd1 or the activation of Cdc42
Hayakawa et al., Genes Cells 2008 : Indeed, FGD1 and FGD3 induced significantly different morphological changes in HeLa Tet-Off cells : whereas FGD1 induced long finger-like protrusions, FGD3 induced broad sheet-like protrusions when the level of GTP bound Cdc42 was significantly increased by the inducible expression of FGD3 ... Indeed, FGD1 and FGD3 induced significantly different morphological changes in HeLa Tet-Off cells : whereas FGD1 induced long finger-like protrusions, FGD3 induced broad sheet-like protrusions when the level of GTP bound Cdc42 was significantly increased by the inducible expression of FGD3
Egorov et al., Mol Biol Cell 2009 : These effects depend on FGD1 regulation of Cdc42 activation and its association with the Golgi membranes, and they may contribute to FGDY pathogenesis
Olson et al., Curr Biol 1996 : FGD1 activates Cdc42 , whereas Vav activates Rho, Rac and Cdc42