Gene interactions and pathways from curated databases and text-mining

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GRAP2 — IL33

Text-mined interactions from Literome

Ling et al., Crit Care Med 2002 : In contrast to its effects on the janus kinase/STAT pathways, interleukin-6 activation of MAP kinases ( extracellular signal regulated kinase-1, extracellular signal regulated kinase-2, and p38 ) was unaffected by endotoxin
Yan et al., J Biol Chem 2002 : This model probiotic also inhibits activation of the pro-apoptotic p38/mitogen activated protein kinase by tumor necrosis factor, interleukin-1alpha , or gamma-interferon
Yndestad et al., Int J Biochem Cell Biol 2010 (Inflammation) : However, pretreatment with endothelin-1 only inhibited activation of p38-MAPK by IL-33 with no significant influence on ERK1/2 and a small increase in activation of JNKs. Inhibition of p38-MAPK signalling following pretreatment with endothelin-1 was also detected with IL-1beta, H ( 2 ) O ( 2 ) or tumour necrosis factor alpha (TNFalpha) indicating an effect intrinsic to the signalling pathway
Rasheed et al., Arthritis Res Ther 2010 (Osteoarthritis) : Pomegranate extract inhibits the interleukin-1ß induced activation of MKK-3, p38a-MAPK and transcription factor RUNX-2 in human osteoarthritis chondrocytes