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MMP14 — PI3

Text-mined interactions from Literome

Zhang et al., Oncogene 2003 (Carcinoma, Lewis Lung...) : MT1-MMP induction and invasion were blocked by the PI 3-kinase inhibitors LY294002 and wortmannin and by rapamycin, but not by the MEK inhibitor PD98059
Fahem et al., Int J Biochem Cell Biol 2008 : Inhibitors of PI(3)-kinase and MEK1/2 suppressed elastokine mediated MT1-MMP expression at both the mRNA and protein levels, and decreased the ability of elastokines to accelerate pseudotube formation
Kuo et al., Int J Cancer 2009 (Breast Neoplasms...) : TGF-beta induced MT1-MMP expression was blocked by the specific extracellular regulated kinase-1/2 ( ERK1/2 ) inhibitor PD98059 and the specific phosphoinositide 3-OH kinase (PI3K) inhibitor LY294002
Zhang et al., Int J Gynecol Cancer 2009 (Carcinoma...) : Membrane type 1 matrix metalloproteinase induction was blocked by mitogen activated protein kinase or extracellular signal regulated kinase inhibitors PD98059 and U0126 but not by phosphatidylinositol-3 kinase (PI3-K) inhibitors LY294002 and wortmannin
Furundzija et al., Biochem Biophys Res Commun 2010 (Atherosclerosis) : This involves activation of integrins and focal adhesion formation via inside-out PI3-kinase/PKC/p38 dependent signaling, but does not require MMP activation
Shimizu-Hirota et al., Genes Dev 2012 : In turn, MT1-MMP dependent PI3Kd activation regulates the immunoregulatory Mi-2/NuRD nucleosome remodeling complex that is responsible for controlling macrophage immune response