Kanoh et al., Cell Signal 2000
:
We examined the effect of PTX on insulin induced glucose uptake, diacylglycerol ( DG ) -protein kinase C ( PKC ) signalling, phosphatidylinositol (PI) 3-kinase and PKC zeta activation and insulin induced tyrosine phosphorylation of Gialpha to clarify the role of G-protein for insulin mediated signal transduction mechanism in rat adipocytes and soleus muscles
Lin et al., Mol Pharmacol 2003
:
PTX blocks Akt but not phosphatidylinositol 3-kinase (PI3K) activation in response to PDGF and abrogates cyclin D1 induction by PI3K, suggesting an effect of PTX on Akt itself