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CREB1 — SIK1
Text-mined interactions from Literome
Katoh et al., Eur J Biochem 2004
:
This suggests that
SIK1 may
regulate the intracellular movement of TORC2, and as a result modulates the
CREB dependent transcription activity ... Together, these results indicate that the RK-rich region of SIK1 is important for determining the nuclear localization and attenuating CREB repressing activity, but the degree of the nuclear localization of SIK1 itself does not necessarily reflect the degree of
SIK1 mediated
CREB repression
Takemori et al., J Steroid Biochem Mol Biol 2008
:
Regulation of
CREB mediated gene expression by
salt inducible kinase ...
SIK represses the activity of
CRE binding protein ( CREB ) by phosphorylating a CREB-specific co-activator transducer of regulated CREB activity ( TORC )
Takemori et al., Endocr J 2009
:
Meanwhile,
SIK1 represses the transcription factor cAMP-response element binding protein (
CREB ) by phosphorylating its co-activator transducer of regulated CREB activity ( TORC ) ... Meanwhile,
SIK1 represses the transcription factor cAMP-response element binding protein (
CREB ) by phosphorylating its co-activator transducer of regulated CREB activity ( TORC )
Jefcoate et al., Mol Cell Endocrinol 2011
:
A second protein,
CREB regulated transcription coactivator ( TORC/CRTC ), enhances this recruitment, but is
inhibited by
salt inducible kinase ( SIK )