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PRKACB — STAR

Text-mined interactions from Literome

Sekar et al., Endocrinology 2000 : Together, these investigations document a significant role for insulin or IGF-I in enhancing LH-stimulated progesterone and cAMP biosynthesis and endogenous StAR message and protein accumulation and in augmenting cAMP-PKA dependent transcriptional activation of the exogenous StAR promoter
Lopez et al., Endocrine 2001 : The involvement of cyclic adenosine monophosphate cAMP dependent protein kinase A (PKA) in the regulation of the steroidogenic acute regulatory protein ( StAR ) and the high-density lipoprotein receptor ( HDL-R ) genes by steroidogenic factor-1 (SF-1) and cAMP were examined
Tremblay et al., Endocrinology 2002 : Moreover, we show that GATA-4 and C/EBPbeta directly interact in vitro and in vivo and synergistically activate the StAR promoter in CV-1 cells exclusively in the presence of PKA
Chen et al., Int J Biochem Cell Biol 2005 (Leydig Cell Tumor...) : Moreover, CS induced the expression of steroidogenic acute regulatory (StAR) protein in dose- and time dependent relationships, and PKA inhibitor, PKC inhibitor, or co-treatment with both inhibitors suppressed it
Dyson et al., Biol Reprod 2008 : The expression of the steroidogenic acute regulatory protein ( STAR ) is regulated by PKA in response to trophic hormone stimulation through the second messenger cAMP
Kostic et al., Stress 2008 : Thus, PKA mediated phosphorylation of StAR protein is an important mechanism in the adaptive response of Leydig cells to repeated IMO
Dyson et al., Mol Cell Endocrinol 2009 (Leydig Cell Tumor) : This includes the PKA dependent expression and activation of the steroidogenic acute regulatory protein ( STAR ), which mediates the rate limiting step of steroidogenesis by inducing the transfer of cholesterol from the outer to the inner mitochondrial membrane
Kowalewski et al., Mol Cell Endocrinol 2010 : Our results suggest that VIP induced STAR expression and function in granulosa cells result from the preferential activation of Type I PKA
Jefcoate et al., Mol Cell Endocrinol 2011 : StAR transcription is directly activated by PKA phosphorylation
Manna et al., J Biol Chem 2013 (Second Messenger Systems) : These findings provide novel insight and demonstrate the molecular events by which HSL acts to drive cAMP/PKA mediated regulation of StAR expression and steroidogenesis in mouse Leydig cells