Gene interactions and pathways from curated databases and text-mining

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RHOA — VEGFA

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

van Nieuw Amerongen et al., Arterioscler Thromb Vasc Biol 2003 : VEGF induced the activation of RhoA and recruited RhoA to the cell membrane of human ECs
Le Boeuf et al., J Biol Chem 2004 : Moreover, geldanamycin inhibited the VEGF induced activation of the small GTPase RhoA , which resulted in an inhibition of phosphorylation of FAK on site Tyr ( 407 )
Saníger et al., J Cell Biochem 2006 : c-Jun kinase mediates expression of VEGF induced at transcriptional level by Rac1 and Cdc42Hs but not by RhoA
Singleton et al., Microvasc Res 2006 (Neoplasms...) : Furthermore, MS, DAMGO and VEGF induced RhoA activation which was inhibited by MNTX or VEGF receptor tyrosine kinase inhibition
Nacak et al., Circ Res 2007 : The depletion of KLEIP in endothelial cells blunted the VEGF induced activation of the monomeric GTPase RhoA but did not alter the VEGF stimulated activation of extracellular signal regulated kinase 1/2
Ispanovic et al., Am J Physiol Cell Physiol 2008 : VEGF stimulation also induced activation of Cdc42 while inhibiting RhoA activity
Bryan et al., FASEB J 2010 : We demonstrate that vascular endothelial growth factor-A ( VEGF ) rapidly induces RhoA activation in endothelial cells ( ECs )
Zhu et al., Cell cycle (Georgetown, Tex.) 2011 (MAP Kinase Signaling System...) : Biochemical analysis suggests that hMSC-CM induces the expression of VEGF of tumor cells as well as the activation of RhoA-GTPase and ERK1/2
Ma et al., Nan Fang Yi Ke Da Xue Xue Bao 2012 (Breast Neoplasms) : [ Role of RhoA in hypoxia induced breast cancer cell VEGF secretion and proliferation, migration and tube formation of HUVECs ] ... To explore the role of RhoA in regulating vascular endothelial growth factor ( VEGF ) secretion level in breast cancer cells and in the proliferation, migration and tube formation of human umbilical vascular endothelial cells ( HUVECs ) under hypoxia ... Under hypoxic condition, RhoA activation promoted VEGF secretion in MCF-7 cells, and RhoA knockdown inhibited VEGF secretion
Wu et al., American journal of physiology. Renal physiology 2013 : VEGF induced RhoA activation was prevented by disrupting caveolae with cholesterol depletion and rescued by cholesterol repletion ... Overexpression of nonphosphorylatable caveolin-1 Y14A prevented VEGF induced RhoA activation and fibronectin upregulation