◀ Back to NOS3
NOS3 — PPARA
Text-mined interactions from Literome
Wang et al., Atherosclerosis 2006
:
However,
effects of
PPARalpha on
endothelial nitric oxide synthase (eNOS) remain unknown ... Inhibitors of
PPARalpha , PI3 kinase and MAPK, respectively, markedly
attenuate bezafibrate induced upregulation of
eNOS
Yakubu et al., J Pharmacol Exp Ther 2007
:
Thus, PPARalpha activation attenuated ET-1 production by agents that mediate brain injury through mechanisms that probably result from
PPARalpha induced increase in
eNOS expression/NO production and complex PKC signaling pathways
Wagner et al., Alcohol Clin Exp Res 2012
:
PPAR? ligands
regulate NADPH oxidase,
eNOS , and barrier function in the lung following chronic alcohol ingestion ... These results indicate that
PPAR? activation reduced expression of
eNOS , Nox1, Nox4, the production of reactive species, and barrier dysfunction caused by chronic alcohol ingestion and suggest that PPAR? represents a novel therapeutic target for strategies designed to reduce the risk of lung injury in patients with a history of chronic alcohol ingestion
Balakumar et al., Br J Pharmacol 2012
(Cardiovascular Diseases) :
This review discusses the potential regulatory
role of
PPAR? on
eNOS expression and activation in improving the function of vascular endothelium
Taneja et al., Cardiovasc Toxicol 2013
:
The vascular protective potential of fish oil in preventing nicotine induced VED may pertain to its additional properties ( besides its lipid lowering effect ) such as activation of
PPAR? and subsequent possible
activation of
endothelial NOS and generation of nitric oxide, and consequent reduction in oxidative stress